Cyclodextrin-based ocular drug delivery systems: A comprehensive review

Wang, Qiuxiang; Zhang, Aiwen; Li, Zhu; Yang, Xuewen; Fang, Guihua; Tang, Bo

doi:10.1016/j.ccr.2022.214919

Cited by 47 publications

(16 citation statements)

References 203 publications

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“…Due to the eye's complex anatomy, increasing the efficiency of current ocular drug delivery systems remains a difficulty. [13] Particularly, the eyes contain multiple physical barriers that greatly limit the bioavailability of the administered drug (Figure 3). [13] The rapid elimination of drugs through tear formation or eyelid blinking often results in patients having to either utilize eye drops with high drug concentrations or instill drops for multiple intervals throughout the day, leading to low patient compliance.…”

Section: Ocular Surface Drug Delivery Through Ophthalmic Solutionsmentioning

confidence: 99%

“…[13] Particularly, the eyes contain multiple physical barriers that greatly limit the bioavailability of the administered drug (Figure 3). [13] The rapid elimination of drugs through tear formation or eyelid blinking often results in patients having to either utilize eye drops with high drug concentrations or instill drops for multiple intervals throughout the day, leading to low patient compliance. [14] The limitations of conventional eye drops have led many researchers to explore hydrogels as an alternative treatment for many ophthalmic diseases.…”

Section: Ocular Surface Drug Delivery Through Ophthalmic Solutionsmentioning

confidence: 99%

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Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell‐based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.

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Section: Ocular Surface Drug Delivery Through Ophthalmic Solutionsmentioning

confidence: 99%

Section: Ocular Surface Drug Delivery Through Ophthalmic Solutionsmentioning

confidence: 99%

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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“…Functionalizing the alcohol groups on the hydrophilic surfaces of cyclodextrins with several molecules can enable their crosslinking and is known to enhance their physiochemical properties. A wide range of cyclodextrin-based formulations has been shown to have great potential for ocular drug delivery [ 18 ].…”

Section: Overview Of Polymeric Nano-based Drug-delivery System (Dds)mentioning

confidence: 99%

Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma

Ashkar

Jain

et al. 2023

Polymers

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The eye has anatomical structures that function as robust static and dynamic barriers, limiting the penetration, residence time, and bioavailability of medications administered topically. The development of polymeric nano-based drug-delivery systems (DDS) could be the solution to these challenges: it can pass through ocular barriers, offering higher bioavailability of administered drugs to targeted tissues that are otherwise inaccessible; it can stay in ocular tissues for longer periods of time, requiring fewer drug administrations; and it can be made up of polymers that are biodegradable and nano-sized, minimizing the undesirable effects of the administered molecules. Therefore, therapeutic innovations in polymeric nano-based DDS have been widely explored for ophthalmic drug-delivery applications. In this review, we will give a comprehensive overview of polymeric nano-based drug-delivery systems (DDS) used in the treatment of ocular diseases. We will then examine the current therapeutic challenges of various ocular diseases and analyze how different types of biopolymers can potentially enhance our therapeutic options. A literature review of the preclinical and clinical studies published between 2017 and 2022 was conducted. Thanks to the advances in polymer science, the ocular DDS has rapidly evolved, showing great promise to help clinicians better manage patients.

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“…Cyclodextrin (CD) is characterized by an outer cavity that is hydrophilic and an inner cavity that is hydrophobic, and it is a promising medicinal excipient due to its exceptional capacity to create inclusion complexes with low-molecular-weight molecules and polymers. Over the last two decades, numerous CD-based ocular drug delivery methods have been developed . Teng et al studied cationic β-CD derivatives to solve the metformin hydrochloride degradation problem before reaching the intestine .…”

Section: Polymeric Nanoparticles In Drug Deliverymentioning

confidence: 99%

Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges

Rad,

Soylukan,

Kulabhusan

et al. 2023

ACS Appl. Mater. Interfaces

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Cyclodextrin-based ocular drug delivery systems: A comprehensive review

Cited by 47 publications

References 203 publications

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma

Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges

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