Cyclodextrin-functionalized polymers as drug carriers for cancer therapy

Wei, Hua; Yu, Cui‐Yun

doi:10.1039/c4bm00417e

Cited by 39 publications

(22 citation statements)

References 66 publications

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“…Additionally, it can be easily modified around a pendant group attached to the amide, allowing for further functionalisation, including the potential to bind a drug forming a pro-drug. 35,36 In contrast, PEG polymerisation typically involves complex synthetic routes and the use of toxic reactants. 20 Additionally, it has been shown that in rats, POZ is much more readily excreted via the renal route, does not bioaccumulate and is biodegradable under certain conditions, whereas PEG can bioaccumulate and form vacuoles in some organs.…”

Section: Nanoparticle Diffusion Through Mucus and Stomach Tissuementioning

confidence: 99%

POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

Mansfield

Sillence²,

Hole³

et al. 2015

Nanoscale

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The increasing use of nanoparticles in the pharmaceutical industry is generating concomitant interest in developing nanomaterials that can rapidly penetrate into, and permeate through, biological membranes to facilitate drug delivery and improve the bioavailability of active pharmaceutical ingredients. Here, we demonstrate that the permeation of thiolated silica nanoparticles through porcine gastric mucosa can be significantly enhanced by their functionalization with either 5 kDa poly(2-ethyl-2-oxazoline) or poly(ethylene glycol). Nanoparticle diffusion was assessed using two independent techniques; Nanoparticle Tracking Analysis, and fluorescence microscopy. Our results show that poly(2-ethyl-2-oxazoline) and poly(ethylene glycol) have comparable abilities to enhance diffusion of silica nanoparticles in mucin dispersions and through the gastric mucosa. These findings provide a new strategy in the design of nanomedicines, by surface modification or nanoparticle core construction, for enhanced transmucosal drug delivery.

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Section: Nanoparticle Diffusion Through Mucus and Stomach Tissuementioning

confidence: 99%

POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

Mansfield

Sillence²,

Hole³

et al. 2015

Nanoscale

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“…The direct synthesis of other single-isomer derivatives is more difficult, due to the number of theoretically possible isomers. Monosubstituted derivatives are used in catalysis, [38][39][40][41] separation techniques, [35,[42][43][44] biomedical applications, [45][46][47] nanotechnologies [37,48] and sensors, [49] or as components of supramolecular assemblies. However, scientists have been devoting great efforts to add more than one functional group to a CD skeleton.…”

Section: General Methods For Synthesis and Characterisation Of Monosumentioning

confidence: 99%

“…[37] Of all these CD derivatives, the monosubstituted variants have achieved a prominent position because of their versatility. Monosubstituted derivatives are used in catalysis, [38][39][40][41] separation techniques, [35,[42][43][44] biomedical applications, [45][46][47] nanotechnologies [37,48] and sensors, [49] or as components of supramolecular assemblies. [50][51][52][53][54] The number of known monosubstituted CD derivatives is enormous and their listing would exceed the scope of this review.…”

Section: General Methods For Synthesis and Characterisation Of Monosumentioning

confidence: 99%

Monosubstituted Cyclodextrins as Precursors for Further Use

Řezanka

2016

Eur J Org Chem

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Cyclodextrin derivatives find use in a broad field of applications (e.g., nanomaterials, biomedical applications, catalysis, separation techniques, sensors etc.), with monosubstitution allowing cyclodextrins to be attached to various types of surfaces or for a new feature to be introduced onto a cyclodextrin skeleton (recognition, catalysis, …). Although an enormous number of monosubstituted cyclodextrin derivatives have been synthesised, this review focuses only on the synthesis of several interesting monosubstituted derivatives (allyl, cinnamyl, propargyl, formylmethyl, carboxymethyl, azido and amino) suitable for further modifications. These derivatives allow the synthesis of an unlimited number of desired cyclodextrin derivatives. Using a cyclodextrin derivative already monosubstituted with a suitable functional group is much easier than the optimisation of monosubstitution for every new cyclodextrin derivative desired.

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“…To date, various delivery platforms for chemotherapy agents have been developed to help diagnose and treat cancer. For instance, natural cyclic oligosaccharides β‐cyclodextrins (β‐CD) consist of seven glucopyranose units have widespread applications for drug delivery because of their low toxicity, biocompatibility, and biodegradability, etc . Studies showed that twin‐arginine can deliver QDs into living cells .…”

Section: Introductionmentioning

confidence: 99%

“…For instance, natural cyclic oligosaccharides β-cyclodextrins (β-CD) consist of seven glucopyranose units have widespread applications for drug delivery because of their low toxicity, biocompatibility, and biodegradability, etc. [27][28][29][30] Studies showed that twin-arginine can deliver QDs into living cells. [31] And QDs containing CdS and CdSe/CdS could be made water-soluble by modifying the surfaces with monothiolated β-CD.…”

Section: Introductionmentioning

confidence: 99%

The delivery of doxorubicin of multifunctional β‐cyclodextrin‐modified CdSe/ZnS quantum dots for bioactivity and nano‐probing

et al. 2017

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The modified quantum dots (QDs) have been used in intracellular probing and drug delivery because of their special chemical and physical properties. In this paper, two β-cyclodextrin (β-CD)-modified CdSe/ZnS QDs with strong optical emission properties were synthesized as drug carriers to induce apoptosis. The positively charged l-Arginine (l-Arg) and neutral l-Tryptophan (l-Trp) were selected as ligands to compare the effect of charge on bioactivity of QDs nanoparticles. The in vitro assays revealed that these modified QDs showed good Dox carrier ability and significantly high inhibition rate to cancer cells. Especially, the more positively charged β-CD-l-Arg-polyamine-coated CdSe/ZnS QDs could effectively deliver the doxorubicin (Dox) into cells and exhibit excellent cell selectivity in cancer versus normal cells. The Dox-loaded QDs could enter intracellular, which showed that the Dox can efficiently go through the membranes at the existence of β-CD. Several lines of evidence suggest that the Dox-loaded QDs can efficiently induce apoptosis likely related to the production of ROS. We expect that the modified QDs can enhance the amount of hydrophobic antitumor drugs in cells and can also be used as fluorescent imaging agents.

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Cyclodextrin-functionalized polymers as drug carriers for cancer therapy

Cited by 39 publications

References 66 publications

POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

Monosubstituted Cyclodextrins as Precursors for Further Use

The delivery of doxorubicin of multifunctional β‐cyclodextrin‐modified CdSe/ZnS quantum dots for bioactivity and nano‐probing

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