Cyclodextrin-grafted barium titanate nanoparticles for improved dispersion and stabilization in water-based systems

Serra-Gómez, R.; Martínez-Tarifa, Juan Manuel; González‐Benito, J.; González‐Gaitano, Gustavo

doi:10.1007/s11051-015-3321-x

Cited by 9 publications

(14 citation statements)

References 49 publications

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“…In the same sequence, recently a study was carried out using high‐energy ball milling (HEBM) under the temperature of the liquid nitrogen (cryomilling). The dispersion results were interesting but the process remains less economic …”

Section: Resultsmentioning

confidence: 99%

BaTiO₃ incorporation effect on the dielectric properties of polymer from aqueous emulsion: An enhanced dispersion technique

Zyane

Belfkira²,

Brouillette

et al. 2016

J of Applied Polymer Sci

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An economic and environment friendly process was adapted to synthesize new dielectric composite materials. Using ethylene vinyl acetate (EVA)/vinyl ester of versatic acid (VeoVa) terpolymer as an aqueous emulsion provides a homogenous dispersion of BaTiO 3 (BT) particles, due to the high viscosity and polarity of the vinyl resin (VR). Composites films were obtained from these dispersions by water evaporation. The evolution of the dielectric properties as a function of the BaTiO 3 content, was correctly fitted by a Maxwell-Garnett model. This fitting of the experimental curve shows a good dispersion of filler in the vinyl resin and the particles separation by a layer of resin as expected for the preparation method used in this study. The VR/BT composites show good synergy between the dielectric properties of the different phases of the composites due to the formation of macrodipoles and to the strong interactions between polar EVA/VeoVa groups and the BaTiO 3 particles surface. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44333.

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Section: Resultsmentioning

confidence: 99%

BaTiO₃ incorporation effect on the dielectric properties of polymer from aqueous emulsion: An enhanced dispersion technique

Zyane

Belfkira²,

Brouillette

et al. 2016

J of Applied Polymer Sci

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“…30,60,61 The surface modified BT with CDs, which helps to stabilize the nanoparticles in solution, display excellent viability of the cells, even up to concentrations of 200 μg/mL. 39 Figure 10 shows the MTT results for the T1107 hydrogels at different concentrations with and without BT200-βCD nanoparticles. Tetronic T1107 shows cytotoxicity scores of 0 (<90%) and 1 (70-90%) after 72h at all the concentrations but the highest one (25 wt%), with and without BT nanoparticles.…”

Section: Cytotoxicity Studiesmentioning

confidence: 99%

Structure and Rheology of Poloxamine T1107 and Its Nanocomposite Hydrogels with Cyclodextrin-Modified Barium Titanate Nanoparticles

et al. 2016

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We report the preparation of a nanocomposite hydrogel based on a poloxamine gel matrix (Tetronic T1107) and cyclodextrin (CD)-modified barium titanate (BT) nanoparticles. The micellization and sol-gel behavior of pH-responsive block copolymer T1107 were fully characterized by small-angle neutron scattering (SANS), dynamic light scattering (DLS), and Fourier transform infrared attenuated total reflectance (FTIR-ATR) spectroscopy as a function of concentration, pH and temperature. SANS results reveal that spherical micelles in the low concentration regime present a dehydrated core and highly hydrated shell, with a small aggregation number and size, highly dependent on the degree of protonation of the central amine spacer. At high concentration, T1107 undergoes a sol-gel transition, which is inhibited at acidic pH. Nanocomposites were prepared by incorporating CD-modified BT of two different sizes (50 and 200 nm) in concentrated polymer solutions. Rheological measurements show a broadening of the gel region, as well as an improvement of the mechanical properties, as assessed by the shear elastic modulus, G' (up to 200% increase). Initial cytocompatibility studies of the nanocomposites show that the materials are nontoxic with viabilities over 70% for NIH3T3 fibroblast cell lines. Overall, the combination of Tetronics and modified BaTiO3 provides easily customizable systems with promising applications as soft piezoelectric materials.

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“…As an effort to combat this shortcoming, cyclodextrin (CD)-stabilized BTNPs were prepared by first hydroxylating the nanoparticle surface and then covalently attaching CD molecules, leading to stable and noncytotoxic dispersions of BTNPs. 29 However, BTNP stabilization through covalent binding of a hydrophilic polymer such as poly(ethylene glycol) (widely utilized in drug delivery for its superior ability to increase the solubility of hydrophobic substances) has not been reported.…”

Section: ■ Introductionmentioning

confidence: 99%

Antibody-Conjugated Barium Titanate Nanoparticles for Cell-Specific Targeting

Jordan

O'Brien

Spatarelu

et al. 2020

ACS Appl. Nano Mater.

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Barium titanate nanoparticles (BTNPs) are gaining popularity in biomedical research because of their piezoelectricity, nonlinear optical properties, and high biocompatibility. However, the potential of BTNPs is limited by the ability to create stable nanoparticle dispersions in water and physiological media. In this work, we report a method of surface modification of BTNPs based on surface hydroxylation followed by covalent attachment of hydrophilic poly(ethylene glycol) (PEG) polymers. This polymer coating allows for additional modifications such as fluorescent labeling, surface charge tuning, or directional conjugation of IgG antibodies. We demonstrate the conjugation of anti-EGFR antibodies to the BTNP surface and show efficient molecular targeting of the nanoparticles to A431 cells. Overall, the reported modifications aim to expand the BTNP applications in molecular imaging, cancer therapy, or noninvasive neurostimulation.

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Cyclodextrin-grafted barium titanate nanoparticles for improved dispersion and stabilization in water-based systems

Abstract: G. (2016). Cyclodextringrafted barium titanate nanoparticles for improved dispersion and stabilization in water-based systems.

Cited by 9 publications

References 49 publications

BaTiO₃ incorporation effect on the dielectric properties of polymer from aqueous emulsion: An enhanced dispersion technique

BaTiO₃ incorporation effect on the dielectric properties of polymer from aqueous emulsion: An enhanced dispersion technique

Structure and Rheology of Poloxamine T1107 and Its Nanocomposite Hydrogels with Cyclodextrin-Modified Barium Titanate Nanoparticles

Antibody-Conjugated Barium Titanate Nanoparticles for Cell-Specific Targeting

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Cyclodextrin-grafted barium titanate nanoparticles for improved dispersion and stabilization in water-based systems

Abstract: G. (2016). Cyclodextringrafted barium titanate nanoparticles for improved dispersion and stabilization in water-based systems.

Cited by 9 publications

References 49 publications

BaTiO3 incorporation effect on the dielectric properties of polymer from aqueous emulsion: An enhanced dispersion technique

BaTiO3 incorporation effect on the dielectric properties of polymer from aqueous emulsion: An enhanced dispersion technique

Structure and Rheology of Poloxamine T1107 and Its Nanocomposite Hydrogels with Cyclodextrin-Modified Barium Titanate Nanoparticles

Antibody-Conjugated Barium Titanate Nanoparticles for Cell-Specific Targeting

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BaTiO₃ incorporation effect on the dielectric properties of polymer from aqueous emulsion: An enhanced dispersion technique

BaTiO₃ incorporation effect on the dielectric properties of polymer from aqueous emulsion: An enhanced dispersion technique