Cyclodextrin-grafted chitosan hydrogels for controlled drug delivery

Kono, Hiroyuki; Teshirogi, Taku

doi:10.1016/j.ijbiomac.2014.08.030

Cited by 103 publications

(54 citation statements)

References 60 publications

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“…Since the pioneering work of Wichterle and Lim in 1960 on crosslinked hydrogels [7], and because of their hydrophilic character and potential to be biocompatible, hydrogels have been of great interest to biomaterial scientists for many years [14][15][16].…”

Section: Review Historymentioning

confidence: 99%

History and Applications of Hydrogels

Yahia¹

2015

J Biomed Sci

163

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Hydrogels have existed for more than half century, providing one of the earliest records of crosslinked hydroxyethyl methacrylate (HEMA) hydrogels. Today, hydrogels still fascinate material scientists and biomedical researchers and great strides have been made in terms of their formulations and applications. As a class of material, hydrogels are unique, they consist of a self-supporting, waterswollen three-dimensional (3D) viscoelastic network which permits the diffusion and attachment of molecules and cells. However, hydrogels have recently drawn great attention for use in a wide variety of biomedical applications such as cell therapeutics, wound healing, cartilage/bone regeneration and the sustained release of drugs. This is due to their biocompatibility and the similarity of their physical properties to natural tissue. This review aims to give an overview of the historic and the recent design concept of hydrogels and their several applications based on the old and the most recent publications in this field. Journal of Biomedical Sciences ISSN 2254-609XThis Article is Available in: www.jbiomeds.com 2 Hydrogels can be classified into two distinct categories, the natural and the synthetic hydrogels. Natural hydrogels include collagen, fibrin, hyaluronic acid, matrigel, and derivatives of natural materials such as chitosan, alginate and skill fibers. They remain the most physiological hydrogels as they are components of the extracellular matrix (ECM) in vivo. Two main drawbacks of natural hydrogels, however, make their final microstructures and properties difficult to control reproducibly between experiments. First, the fine details of their mechanical properties and their dependence on polymerization or gelation conditions are often poorly understood. Second, due to their natural origin (bovine fibrinogen, rat tail collagen… their composition may vary from one batch to another.In contrast, synthetic hydrogels such as poly (ethylene glycol) diacrylate, poly(acryl amide), poly(vinyl alcohol) are more reproducible, although their final structure can also depend on polymerization conditions in a subtle way, so that a rigorous control of the preparation protocol, including temperature and environment control, may be necessary. Generally speaking, synthetic hydrogels offer more flexibility for tuning chemical composition and mechanical properties; users can, for example vary the concentration or molecular weight of the precursor, or alter the percentage of crosslinkers. They can also be selected or tuned to be hydrolysable or biodegradable over variable periods of time.Hydrogels may be chemically stable or they may degrade and eventually disintegrate and dissolve. They are called «reversible» or «physical» gels when the networks are held together by molecular entanglements, and/or secondary forces including ionic, H-bonding or hydrophobic forces (Figure 2) [3]. Physical hydrogels are not homogeneous, since clusters of molecular entanglements, or hydrophobically-or ionically-associated domains, can create in h...

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Section: Review Historymentioning

confidence: 99%

History and Applications of Hydrogels

Yahia¹

2015

J Biomed Sci

163

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“…Kono et al [56] were prepared β-cyclodextrin-grafted carboxymethyl chitosan hydrogels (CD-g-CMCs) using a water soluble carbodiimide in the presence of N-hydorxyl succiniimide. The prepared hydrogels were examined for their potential use as carriers for drug delivery system.…”

Section: Biomedical Application Model Drug Used Types Of Hydrogels Rementioning

confidence: 99%

Effective Drug Delivery System of Biopolymers Based On Nanomaterials and Hydrogels - A Review

Gopi¹,

Amalraj²,

Thomas³

2016

Drug Des

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Design and synthesis of well-ordered drug delivery systems are very important for medicinal and pharmaceutical and health care. Innovations of materials through nanotechnology and hydrogels have synergistically energized the growth of drug delivery. Uniqueness in material chemistry permits the creation of environmentally approachable, biocompatible, biodegradable and targeted drug delivery system. Large numbers of biopolymers have been examined for the design of drug delivery systems. Structure, size, shape and multi-functionality of drug delivery system can be controlled by the nanotechnology combined with biopolymer. Hydrogels have also been investigated as smart delivery systems capable to release, at the appropriate time and site of action, entrapped drugs in response to specific physiological triggers. This review mainly focuses on drug delivery applications of nanoparticles modified biopolymers and effective drug delivery system of biopolymer network based on hydrogels.

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“…The natural mucoadhesive properties of CS (Grabovac et al, 2005) and its ability to open the tight junctions among epithelial cells are improved/enhanced by association with CDs, e.g. acquiring ability to carry hydrophobic drugs (Kono and Teshirogi, 2015;Venter et al, 2006).…”

Section: Anionic CD Derivatives In Pharmaceutical Nanotechnologymentioning

confidence: 99%