Cyclodextrin-mesoporous silica particle composites for controlled antibiotic release. A proof of concept toward colon targeting

Stjern, Louise; Voittonen, Sandra; Weldemichel, Rahel; Thuresson, Sofia; Agnes, Marco; Benkovics, Gábor; Fenyvesi, Éva; Yannakopoulou, Konstantina; Feiler, Adam; Valetti, Sabrina

doi:10.1016/j.ijpharm.2017.05.062

Cited by 20 publications

(12 citation statements)

References 41 publications

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“…It is a natural "molecular capsule" due to its hydrophilic surface and inside chiral hydrophobic lumen and approved excipients in oral, topical and parenteral drugs (Duchene, Bochot, Yu, Pepin, & Seiller, 2003;Loftsson & Duchêne, 2007;Raut, Manne, Kalthur, Jain, & Mutalik, 2019). Hydrophobic drug molecules can be loaded in the annular empty tube of cyclodextrin, which can improve the dissolution and prolong the efficacy of drugs (Stjern et al, 2017;Vyas, Saraf, & Saraf, 2008…”

Section: Natural Polymersmentioning

confidence: 99%

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Recent progress in preparation and agricultural application of microcapsules

Teng

Mao

et al. 2019

J Biomedical Materials Res

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Recent advances in life science technology have prompted the need to develop microcapsule delivery systems that can encapsulate many different functional or active materials such as drugs, peptides, and live cells, etc. The encapsulation technology is now commonly used in medicine, agriculture, food, and other many fields. The application of biodegradable microcapsule systems can not only effectively prevent the degradation of core materials in the body or the biological environment, but also improve the bioavailability, control the release and prolong the halftime or storage of core active materials. Various wall materials, preparation methods, encapsulation processes, and release mechanisms are covered in this review, as well as several main factors including pH values, temperatures, particle sizes, and additives, which can strongly influence the encapsulation efficiency, the strength, and release of microcapsules. The improvement of coating materials, preparation techniques, and challenges are also highlighted, as well as application prospects. K E Y W O R D Scontrolled release, encapsulation efficiency, microcapsules, preparation method, wall material

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Section: Natural Polymersmentioning

confidence: 99%

“…Preparation methods of microcapsulesFeng et al, 2014;Haidar, Hamdy, & Tabrizian, 2008a;Liu, Liu, Liu, Li, & Liu, 2013;Stjern et al, 2017;Vos, Faas, Spasojevic, & Sikkema, 2010;Xie et al, 2019;Yan et al, 2017;Zhao et al, 2007) …”

mentioning

confidence: 99%

Recent progress in preparation and agricultural application of microcapsules

Teng

Mao

et al. 2019

J Biomedical Materials Res

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“…MTZ is also commonly used in cats [10], dogs [11,12], cows [13] and horses [14], despite the known genotoxic, carcinogenic and mutagenic properties of nitroimidazoles and their metabolites to mammals and humans [15,16]. To reduce the side effects in humans and animals, minimize the environmental impact and mitigate the threat of drug-resisting microbials, efforts have been made to either improve the bioavailability of MTZ [17] or synthesize new compounds with better safety profiles [18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Improving the Solubility, Dissolution, and Bioavailability of Metronidazole via Cocrystallization with Ethyl Gallate

Hao

Wang

et al. 2021

Pharmaceutics

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Metronidazole (MTZ) is an antibacterial drug widely used for the treatment of protozoan and anaerobic infections in humans and animals. However, its low bioavailability necessitates the frequent administration of a high dose to attain an effective plasma concentration profile for therapy. To reduce the dose of MTZ, we have prepared a new cocrystal between MTZ and ethyl gallate (EG). The solid-state properties of MTZ-EG were characterized using complimentary techniques, including thermal, spectroscopic, microscopic, and X-ray crystallographic methods. The MTZ-EG cocrystal exhibits a higher solubility and faster dissolution than MTZ. The bioavailability of MTZ in rats was increased by 36% when MTZ-EG was used.

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“…Met was included in mucoadhesive tablets composed of cellulose and polyacrylic acid derivatives [ 11 ], nanospheres made of amphiphilic β-cyclodextrin [ 12 ] and in calcium pectinate beads [ 13 ]. Cyclodextrins and mesoporous silica particles were combined as a composite to reduce the rate of drug liberation [ 14 ]. An ionic gelation technique was employed to create Met-loaded chitosan nanoparticles capable of pH-triggered sustained release [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Metronidazole in Biocompatible Macrocycles and Structural Characterization of Its Nano Spray-Dried Nanostructured Composite

et al. 2021

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Due to the great potential of biocompatible cucurbit[7]uril (CB7) and 4-sulfonatocalix[4]arene (SCX4) macrocycles in drug delivery, the confinement of the pharmaceutically important metronidazole as an ionizable model drug has been systematically studied in these cavitands. Absorption and fluorescence spectroscopic measurements gave 1.9 × 105 M−1 and 1.0 × 104 M−1 as the association constants of the protonated metronidazole inclusion in CB7 and SCX4, whereas the unprotonated guests had values more than one order of magnitude lower, respectively. The preferential binding of the protonated metronidazole resulted in 1.91 pH unit pKa diminution upon encapsulation in CB7, but the complexation with SCX4 led to a pKa decrease of only 0.82 pH unit. The produced protonated metronidazole–SCX4 complex induced nanoparticle formation with protonated chitosan by supramolecular crosslinking of the polysaccharide chains. The properties of the aqueous nanoparticle solutions and the micron-sized solid composite produced therefrom by nano spray drying were unraveled. The results of the present work may find application in the rational design of tailor-made self-assembled drug carrier systems.

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Cyclodextrin-mesoporous silica particle composites for controlled antibiotic release. A proof of concept toward colon targeting

Cited by 20 publications

References 41 publications

Recent progress in preparation and agricultural application of microcapsules

Recent progress in preparation and agricultural application of microcapsules

Improving the Solubility, Dissolution, and Bioavailability of Metronidazole via Cocrystallization with Ethyl Gallate

Encapsulation of Metronidazole in Biocompatible Macrocycles and Structural Characterization of Its Nano Spray-Dried Nanostructured Composite

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