Cyclodextrin nanoparticle bound oral camptothecin for colorectal cancer: Formulation development and optimization

Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo

“…For this purpose, two different amphiphilic βCDs were used in the study. Non-ionic 6OCaproβCD and cationic PC βCDC6 were used in our previous studies to create nano-sized carrier systems for anti-cancer drugs through oral or parenteral administration routes [13,[15][16][17]19,31]. Our formulation development studies revealed both CDs as optimal carriers for PCX in our previous studies through cell culture studies and detailed in vitro characterization data including particle size, drug-loading efficiency, drug release profile, stability, hemolysis, and cytotoxicity in healthy cells [15,31].…”

“…The results suggest that the drug loading and cellular interaction of the CD nanoparticles can easily be modulated by coating with a positively charged biocompatible material with penetration enhancer properties such as chitosan. Thus, camptothecin-loaded CD nanoparticles can be effective in improving the oral bioavailability and decreasing the dosing frequency, thereby minimizing the dose-dependent adverse effects and maximizing the patients' compliance [17][18][19].…”

“…In addition, their dense hydroxyl display can be selectively functionalized to render an array of amphiphilic structures featuring spontaneous self-assembling capabilities in an aqueous environment, whose functional properties (i.e., stability, encapsulation capabilities, surface, interaction abilities, or environmental sensitivity) can be tailored. In fact, these nanodelivery systems were applied for the delivery of various anticancer drugs such as PCX [13][14][15], erlotinib [16], camptothecin [17][18][19], docetaxel [20], genistein [21], sorafenib [22], and quercetin/silibinin [23]. In addition, it has been preferred in studies to increase the effectiveness of various molecules besides anti-cancer drugs in different strategies such as gene silencing or phototherapy in cancer treatment [24][25][26][27][28][29][30].…”

Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin

“…Another interesting strategy to solve the inconveniences of camptothecin and facilitate its oral administration would be its encapsulation in nanocarriers, including lipid-based nanoparticles ( Yang et al, 1999 ; Du et al, 2018 ), dendrimers ( Sadekar et al, 2013 ), and polymer nanoparticles ( Huarte et al, 2016 ; Ünal et al, 2020 ). In this context, an alternative to increase the oral absorption of this drug may be its encapsulation in nanoparticles capable of diffusing through the mucus layer and, then, of reaching the mucosal epithelium surface in order to increase their residence time in close contact with the absorptive membrane.…”

Rational formulation engineering of fraxinellone utilizing 6-O-α-D-maltosyl-β-cyclodextrin for enhanced oral bioavailability and hepatic fibrosis therapy

“…Elucidating the pre-absorption risks is a key prerequisite for the rational design of oral drug formulations (Ünal et al., 2020 ). Particularly, the physicochemical properties of drugs and their stability in the gastrointestinal tract are fundamental to the selection of oral formulation strategy (Sun et al., 2012 ; Jambhekar & Breen, 2013 ).…”