Cyclodextrin Nanosponges

Swaminathan, Shankar; Trotta, Francesco

doi:10.1002/9783527341009.ch2

“…According to the literature, the area at 1700-1800 cm −1 is ideal for determining the crystallinity of cyclodextrin nanosponges [12,25,26].The C=O bond of crystalline nanosponges showed a minor peak shift of around +40 cm-1 at 1780.05 cm -1 [25].The typical peak of carbonate bond between CD units was seen at roughly 1740 cm -1 in conventionally synthesized nanosponges but was moved to higher values (1780 cm -1 ) in wave synthesized nanosponges the lack of the characteristic non-hydrogen-bonded O-H stretching at 3450 cm −1 given by the primary alcohol group in β-CD indicates that the cross-linking process is complete. Carbonate NS has a distinct peak at about 1750 cm −1 [27].…”

Section: Loading Of the Drug Into Nanospongesmentioning

confidence: 99%

Microwave-Assisted Fabrication of Cyclodextrin-Based Nanosponges for Solubility Enhancement

Vij

¹

,

Wadhwa

²

2022

ECS Trans.

3

0

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Cinnarizine is plagued by low aqueous solubility and thereby poor bioavailability. Thus, it could be a model drug whose bioavailability can be improved by enhancing its solubility. The present study focuses on the fabrication of cyclodextrin-based nanosponges using a microwave-assisted approach. Phase solubility studies were performed to shortlist the cyclodextrin. The manufacturing process was streamlined by applying the 3-factor, 3-level Box-Behnken experimental design to optimize the microwave power level, reaction time, and stirring speed. The batch with the least particle size and highest yield was finalized. The prepared nanosponges were characterized for particle size, polydispersity index, zeta potential, drug loading, entrapment efficiency, and FTIR spectroscopy. The in-vitro drug release showed a drastic improvement in the solubility and release of cinnarizine from the nanosponges as compared to that of the plain drug and drug-cyclodextrin physical mixture. The study proved the suitability of this system for the solubility enhancement of cinnarizine.

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“…Hence, these novel carriers have attracted much interest of formulation scientists as they hold promise in addressing other challenges like poor bioavailability, permeation and therapeutic activity [69]. Cyclodextrin nanosponges have also been explored for drug delivery and drug targeting for cancer management [40,109,110]. In the following sections, information regarding their applications in pharmaceutical field has been summarized (…”

Section: Nanosponges In Drug Deliverymentioning

confidence: 99%

Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

Kumar¹,

Dalal²,

Rao³

2020

Colloid Science in Pharmaceutical Nanotechnology

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Nanotechnology showed great promise and impact on administration of therapeutic agents owing to its advantages over contemporary delivery systems. Nanoscale carriers like nanosponges represent a novel category of hyper crosslinked polymer structures with nanosized cavities which can be filled with variety of active moieties (hydrophilic as well as hydrophobic). These nanocarriers can circulate around the body until they found the specific target site and adhere on the surface and release the active moiety in a predictable and controlled manner, resulting in more effective delivery of a given dosage. Nanosponge technology helps to reduce drug associated side effects, improve stability, increase elegance and improve the flexibility of formulations, administered orally, parenterally and topically. Among nanosponges, cyclodextrin-based nanosponges (CDNS) are smart versatile carriers studied widely for drug delivery applications. Statistically, it have presented that approximately 40% of active moieties marketed currently and about 90% of active moieties in their preliminary phase confront problems regarding to solubility. In the past decade, the number of studies describing CDNS has dramatically increased. In the present chapter, scientists working in arena of nanotechnology can get an idea of fabrication, characterization and therapeutic utilities of nanosponges.

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“…Hence, these novel carriers have attracted much interest of formulation scientists as they hold promise in addressing other challenges like poor bioavailability, permeation and therapeutic activity [69]. Cyclodextrin nanosponges have also been explored for drug delivery and drug targeting for cancer management [40,109,110]. In the following sections, information regarding their applications in pharmaceutical field has been summarized (Table 4).…”

Section: Nanosponges In Drug Deliverymentioning

confidence: 99%