Cyclodextrin Nanosponges and their Applications

Trotta, Francesco

doi:10.1002/9780470926819.ch17

Cited by 71 publications

(61 citation statements)

References 28 publications

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“…The final properties of a CD-NS are strongly influenced by the nature of the cross-linker, the degree of cross-linking and the conditions of the synthesis reaction [21]. Several studies on the formulation and use of CD-NSs as nanocarriers have been conducted, showing that CD-NSs are a suitable delivery system for drugs, macromolecules and gases [22][23][24][25][26][27][28][29].…”

Section: L-dopa [(S)-2-amino-3-(34-dihydroxyphenyl)mentioning

confidence: 99%

Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease

Trotta

Caldera

Cavalli

et al. 2016

Expert Opinion on Drug Delivery

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Section: L-dopa [(S)-2-amino-3-(34-dihydroxyphenyl)mentioning

confidence: 99%

Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease

Trotta

Caldera

Cavalli

et al. 2016

Expert Opinion on Drug Delivery

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“…It was not until the work performed by Trotta and co-workers [13] and the syntheses of new kinds of cyclodextrin nanosponges that they revealed their full potential in other fields, particularly as drug carriers.…”

Section: Reviewmentioning

confidence: 99%

“…FTIR and NMR analyses before and after sterilisation show their stability and the absence of degradation [13]. In addition, they do not act as surfactants and can be easily dispersed in water.…”

Section: Reviewmentioning

confidence: 99%

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Cyclodextrin-based nanosponges as drug carriers

Trotta¹,

Zanetti²,

Cavalli³

2012

Beilstein J. Org. Chem.

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303

219

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SummaryCyclodextrin-based nanosponges, which are proposed as a new nanosized delivery system, are innovative cross-linked cyclodextrin polymers nanostructured within a three-dimensional network. This type of cyclodextrin polymer can form porous insoluble nanoparticles with a crystalline or amorphous structure and spherical shape or swelling properties. The polarity and dimension of the polymer mesh can be easily tuned by varying the type of cross-linker and degree of cross-linking. Nanosponge functionalisation for site-specific targeting can be achieved by conjugating various ligands on their surface. They are a safe and biodegradable material with negligible toxicity on cell cultures and are well-tolerated after injection in mice. Cyclodextrin-based nanosponges can form complexes with different types of lipophilic or hydrophilic molecules. The release of the entrapped molecules can be varied by modifying the structure to achieve prolonged release kinetics or a faster release. The nanosponges could be used to improve the aqueous solubility of poorly water-soluble molecules, protect degradable substances, obtain sustained delivery systems or design innovative drug carriers for nanomedicine.

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“…These materials are constituted by hyper-reticulated polymers obtained joining supramolecular host units, as the monomers, by means of a suitable reticulating agent. Up to date, the examples by far most studied are constituted by cyclodextrin-based nanosponges ( Cy NSs) [4–5], which can be synthesized by reacting native β-cyclodextrin with double electrophiles such as epichlorohydrin [6], organic carbonates [7–9] or bis-isocyanates [10], in variable ratios depending on the required degree of reticulation. The process, of course, exploits the nucleophilic reactivity of the hydroxy groups of the macrocycle oligosaccharide unit.…”

Section: Introductionmentioning

confidence: 99%

Hyper-reticulated calixarene polymers: a new example of entirely synthetic nanosponge materials

Spinella¹,

Russo²,

Vincenzo³

et al. 2018

Beilstein J. Org. Chem.

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New calixarene-based nanosponges (CaNSs), i.e., hyper-reticulated polymers constituted by calixarene monomer units joined by means of bis(1,2,3-trialzolyl)alkyl linkers, were synthesized, characterized and subjected to preliminary tests to assess their supramolecular absorption abilities towards a set of suitable organic guests, selected as pollutant models. The synthesis was accomplished by means of a CuAAC reaction between a tetrakis(propargyloxy)calix[4]arene and an alkyl diazide. The formation of the polymeric network was assessed by means of FTIR and 13C{1H} CP-MAS solid-state NMR techniques, whereas morphological characterization was provided by SEM microghaphy. The materials were proved to possess pH-dependent sequestration abilities, due to the presence of the weakly basic triazole linkers. Sequestration efficiency indeed depends on the effective occurrence of both electrostatic and hydrophobic interactions between the guest and the polymer lattice. Thus, our CaNS nanosponges can be considered as a new class of purely synthetic smart absorbent materials.

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Cyclodextrin Nanosponges and their Applications

Cited by 71 publications

References 28 publications

Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease

Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease

Cyclodextrin-based nanosponges as drug carriers

Hyper-reticulated calixarene polymers: a new example of entirely synthetic nanosponge materials

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