Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin

Liao, Rongqiang; Liu, Ying; Lv, Pin; Wu, Di; Xu, Meiling; Zheng, Xiaoyuan

doi:10.1080/10717544.2020.1856223

Cited by 19 publications

(16 citation statements)

References 32 publications

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“…The values of m 1 determined separately for aprotic (1)(2)(3)(4)(5)(6)(7)(8)(9) and protic (10-14) solvents, correlation coefficients and difference in the ground and excited state dipole moment (∆µ) obtained on the basis of McRae (MR), Bakhshiev (B), and Lippert and Mataga (LM) models are also summarized in Table 2.…”

Section: Determination Of the Changes In The Dipole Momentmentioning

confidence: 99%

“…Despite the great potential of modern pharmaceuticals, their low solubility results in poor oral bioavailability [2,3]. To overcome these limitations, polymeric drug carriers are used in which the poorly soluble active substance is dispersed [4][5][6][7]. As was shown, the polymer can decrease the drug crystallization ability due to polymer-drug interactions (such as hydrogen bonding) by reducing drug mobility and limiting drug-drug molecular interactions [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Hydrogen Bonding in Paracetamol–Solvent and Paracetamol–Hydrogel Matrix Interactions

et al. 2021

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The photophysical and photochemical properties of antipyretic drug – paracetamol (PAR) and its two analogs with different substituents (acetanilide (ACT) and N-ethylaniline (NEA)) in 14 solvents of different polarity were investigated by the use of steady–state spectroscopic technique and quantum–chemical calculations. As expected, the results show that the spectroscopic behavior of PAR, ACT, and NEA is highly dependent on the nature of the solute–solvent interactions (non-specific (dipole-dipole) and specific (hydrogen bonding)). To characterize these interactions, the multiparameter regression analysis proposed by Catalán was used. In order to obtain a deeper insight into the electronic and optical properties of the studied molecules, the difference of the dipole moments of a molecule in the ground and excited state were determined using the theory proposed by Lippert, Mataga, McRae, Bakhshiev, Bilot, and Kawski. Additionally, the influence of the solute polarizability on the determined dipole moments was discussed. The results of the solvatochromic studies were related to the observations of the release kinetics of PAR, ACT, and NEA from polyurethane hydrogels. The release kinetics was analyzed using the Korsmayer-Peppas and Hopfenberg models. Finally, the influence of the functional groups of the investigated compounds on the release time from the hydrogel matrix was analyzed.

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Section: Determination Of the Changes In The Dipole Momentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Hydrogen Bonding in Paracetamol–Solvent and Paracetamol–Hydrogel Matrix Interactions

et al. 2021

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“…It usually contains 6-12 D -glucopyranose units 15 . Among these, molecules with six, seven, and eight glucose units are denoted as alpha-, beta-, and gamma- cyclodextrins, which hold great practical significance 16 . Since the glycosidic bond connecting glucose units cannot rotate freely, cyclodextrin exhibits a slightly tapered ring structure instead of cylindrical (Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Yi¹,

Liao²,

Zhao³

et al. 2022

Theranostics

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In the past few years, drug delivery systems have been used extensively to improve solubility, stability, and pharmacokinetics of chemotherapeutic drugs. However, traditional delivery systems fail to fulfill the required standard of effectiveness, primarily owing to issues of drug resistance exhibited by cancer cells and inherent differences among the patients. In this regard, combination therapy offers advantages of synergistic mechanism, reduced drug dosage, and enhanced therapeutic effect, which can be effectively utilized for the treatment of cancer. However, different types of therapeutic agents exhibit different pharmacokinetic properties and action targets in vivo , which lead to uncontrollable concentration ratio of therapeutic agents at the lesion site. This in turn causes serious side effects and affects synergistic anticancer effect. Importantly, multifunctional co-delivery systems are characterized by good pharmacokinetic properties, ability to provide targeted delivery, and controlled release in response to tumor microenvironment. Such delivery systems are widely used for co-delivery of therapeutic agents, which further assist in obtaining better synergistic anticancer effect, and can be potentially used for clinical application. Multifunctional co-delivery systems often exhibit complex structures and construction process. Since cyclodextrin is characterized by self-assembly property, it is possible to quickly construct cyclodextrin-based multifunctional co-delivery systems, with convenience and flexibility. The application of cyclodextrin in the construction of multifunctional co-delivery systems for cancer therapy has gained immense attention in the past few years. The present study provided overview of latest progress in the field of cyclodextrin-based multifunctional co-delivery systems for cancer synergistic therapy.

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“…SCU, the main active component of breviscapine, has poor aqueous solubility (0.02 mg/mL), insufficient chemical stability, short biological half-life (0.7 h to 2.3 h), and rapid plasma elimination rate. There was only a 0.40 or 10.67% oral bioavailability of SCU in rats and dogs, respectively. , Its major metabolites are isoscutellarin (scutellarein-6- O -glucuronide) and 6,7-diglucuronide of scutellarein, which are excreted via the bile and urine. , To circumvent SCU’s limitations, it has been loaded into nanoformulations of bovine serum albumin, chitosan, − and cyclodextrin, − where enhanced solubility, increased stability, and prolonged blood circulation was successfully obtained. However, the efficacy of these SCU-loaded NPs in treating ischemic diseases, such as myocardial or cerebral ischemia, is yet to be evaluated.…”

Section: Introductionmentioning

confidence: 99%

Intravenous Administration of Scutellarin Nanoparticles Augments the Protective Effect against Cerebral Ischemia–Reperfusion Injury in Rats

et al. 2022

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This study investigates the protective effect of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with scutellarin (SCU), a flavone isolated from the traditional Chinese medicineErigeron breviscapus (Vant.) Hand.-Mazz., in reducing cerebral ischemia/reperfusion (I/R) injury in vivo. The focal cerebral I/R injury model was established by occluding the middle cerebral artery for 1 h in male Sprague-Dawley (SD) rats. Our SCU-PLGA NPs exhibited an extended in vitro release profile and prolonged blood circulation in rats with cerebral ischemia. More importantly, when administered intravenously once a day for 3 days, SCU-PLGA NPs increased the SCU level in the ischemic brain, compared to free SCU, resulting in a significant reduction of the cerebral infarct volume after cerebral I/R. Furthermore, SCU-PLGA NPs reversed the histopathological changes caused by cerebral I/R injury, as well as attenuated cell apoptosis in the brain tissue, as confirmed by hematoxylin and eosin, and TUNEL staining. Our findings have revealed that our injectable SCU-PLGA NPs provide promising protective effects against cerebral I/R injury, which could be used in combination with the existing conventional thrombolytic therapies to improve stroke management.

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Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin

Cited by 19 publications

References 32 publications

The Role of Hydrogen Bonding in Paracetamol–Solvent and Paracetamol–Hydrogel Matrix Interactions

The Role of Hydrogen Bonding in Paracetamol–Solvent and Paracetamol–Hydrogel Matrix Interactions

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Intravenous Administration of Scutellarin Nanoparticles Augments the Protective Effect against Cerebral Ischemia–Reperfusion Injury in Rats

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