Cyclodextrins and Biotechnological Applications

Singh, Amit; Kaler, Abhishek; Patil, Rachit; Banerjee, Uttam Chand

doi:10.1002/9780470926819.ch14

Cited by 3 publications

(1 citation statement)

References 81 publications

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“…The effect of CDs in reducing the microbiological load was also observed since they do not constitute a nutrient medium. Furthermore, encapsulation in CDs offers improvement in handling bioactive compounds, with oily or liquid substances transformed to a solid form, and increases the stability of emulsions and thermal stability of oils [ 85 , 87 , 88 , 89 ]. In recent decades, the application of CDs for skin use has been particularly widespread [ 90 ] in products aimed at sun protection, wound healing, acne, psoriasis and dermatitis as well as for use in deodorants and shampoos [ 84 ].…”

Section: Cosmetics Applicationsmentioning

confidence: 99%

Cyclodextrins for the Delivery of Bioactive Compounds from Natural Sources: Medicinal, Food and Cosmetics Applications

Christaki,

Spanidi,

Panagiotidou

et al. 2023

Pharmaceuticals

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Cyclodextrins have gained significant and established attention as versatile carriers for the delivery of bioactive compounds derived from natural sources in various applications, including medicine, food and cosmetics. Their toroidal structure and hydrophobic cavity render them ideal candidates for encapsulating and solubilizing hydrophobic and poorly soluble compounds. Most medicinal, food and cosmetic ingredients share the challenges of hydrophobicity and degradation that can be effectively addressed by various cyclodextrin types. Though not new or novel—their first applications appeared in the market in the 1970s—their versatility has inspired numerous developments, either on the academic or industrial level. This review article provides an overview of the ever-growing applications of cyclodextrins in the delivery of bioactive compounds from natural sources and their potential application benefits.

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Section: Cosmetics Applicationsmentioning

confidence: 99%

Cyclodextrins for the Delivery of Bioactive Compounds from Natural Sources: Medicinal, Food and Cosmetics Applications

Christaki,

Spanidi,

Panagiotidou

et al. 2023

Pharmaceuticals

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Computational and spectroscopic analysis of the Quercetin encapsulation in (2HP-β-CD)2 and (2,6Me-β-CD)2 complexes

Leonis

Vakali

Zoupanou

et al. 2023

Journal of Molecular Structure

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Review of the Usability of Cyclodextrin as a Cosmetic Ingredient

Lee¹,

Park²

2019

Asian J Beauty Cosmetol

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Skin is the outermost barrier of the body, making it vulnerable to various external stimuli that can directly influence skin aging. To maximize the impact of cosmetics that delay skin aging, the stabilization of cosmetic ingredients is necessary. In addition to microencapsulation, liposome, and liquid crystal methods to increase the bioavailability of cyclodextrin, various studies have been conducted that utilize its structural characteristics to improve its properties of solubility, stability, and sustained release. In the present study, we reviewed previous investigations demonstrating that cyclodextrin enhanced the usefulness of various active ingredients as cosmetics materials based on its structural characteristics. Cyclodextrin inclusion complexes of esculin, hydrogel, coenzyme Q10, and genistein were compared with each non-inclusion material. The results showed that cyclodextrin increased solubility and improved skin permeability. Additionally, cysteinyl β-cyclodextrin, formed by combining a structural unit of the amino acid cysteine with β-cyclodextrin, showed a complexing function specific to the flavonoid baicalein. The strongly hydrophilic cysteine site of the complex improved the dissolution of baicalein in water. Therefore, further studies should investigate the various structure-specific host complexes with different cyclodextrin structure derivatives besides the cysteinyl group to enhance the already verified efficacy of the effective ingredients. Furthermore, it is expected that cyclodextrin will be commercialized as a stabilizing material for active ingredients in the cosmetic industry if clinical studies can prove the effectiveness of the β-cyclodextrin inclusion function in functional cosmetics.

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Cyclodextrins and Biotechnological Applications

Cited by 3 publications

References 81 publications

Cyclodextrins for the Delivery of Bioactive Compounds from Natural Sources: Medicinal, Food and Cosmetics Applications

Cyclodextrins for the Delivery of Bioactive Compounds from Natural Sources: Medicinal, Food and Cosmetics Applications

Computational and spectroscopic analysis of the Quercetin encapsulation in (2HP-β-CD)2 and (2,6Me-β-CD)2 complexes

Review of the Usability of Cyclodextrin as a Cosmetic Ingredient

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