Cyclodextrins, Their Value in Pharmaceutical Technology

Duchêne, Dominique; Vaution, C.; Glomot, Frédérique

doi:10.3109/03639048609042630

Cited by 64 publications

(22 citation statements)

References 50 publications

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“…The reduction of volatility can be demonstrated by a rise in the boiling point of solutions, or in the sublimation for solids. [80] Complexation has been used to avoid the destruction of certain flavours, colours or vitamins associated with certain ingredients by processing or on storage. The guest (e.g.…”

Section: Applications Of Cyclodextrin-assisted Molecular Encapsulatiomentioning

confidence: 99%

A review on cyclodextrin encapsulation of essential oils and volatiles

Cabral-Marques

2010

Flavour & Fragrance J

590

360

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Cyclodextrins (CyDs) are cyclic carbohydrates derived from starch. The parent CyDs contain six, seven and eight glucopyranose units and are referred as a-, b-and g-CyD, respectively. The most important property of the CyDs is the ability to establish specific interactions -molecular encapsulation -with various types of molecules through the formation of noncovalently bonded entities, either in the solid phase or in aqueous solution. These nano-encapsulating agents may form inclusion complexes with essential oils and volatiles, or their components, in order to improve their characteristics, such as transformation of liquid compounds into crystalline form; masking unpleasant smells and tastes of some compounds; improving the physical and/or chemical stability; and stabilizing volatile compounds by reducing or eliminating any losses through evaporation. Complexation has been used to avoid the destruction of certain flavours by processing or, on storage, allowing the use of minor amounts of flavours. The guest molecule is released in the warm moisture of the mouth. Examples are spices, essential oils of vegetable origin and plant flavours, chamomile oil and extract, eucalyptus oil, fennel oil, lemon oil, onion and garlic oil, camphor, menthol, thymol, etc. There are several methods for the preparation of inclusion complexes; kneading, co-precipitation, freeze-drying and spray-drying the most commonly used. Evidence for a guest inclusion into the apolar CyD cavity may be proved by various analytical techniques, including NMR spectroscopy, UV-visible absorption spectroscopy, optical rotatory dispersion and circular dichroism, fluorescence, infrared/FT-IR spectroscopy, thermo-analysis, TLC, mass spectromety, and powder X-ray diffractometry.

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Section: Applications Of Cyclodextrin-assisted Molecular Encapsulatiomentioning

confidence: 99%

A review on cyclodextrin encapsulation of essential oils and volatiles

Cabral-Marques

2010

Flavour & Fragrance J

590

360

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“…Os complexos de inclusão com CDs abrem novas perspectivas à utilização dos fármacos Duchêne, Wouessidjewe, 1990a,b;Duchêne et al, 1989;Fujioka et al, 1983;Miyaji et al, 1992;Rajeweski, Stella, 1996;Szejtli, 1990Szejtli, , 1991aThompson, 1997;Veiga et al, 1996).…”

Section: Utilização Terapêutica De Complexos De Inclusão Para Adminisunclassified

Aspectos biofarmacêuticos da formulação de medicamentos para neonatos: fundamentos da complexação de indometacina com hidroxipropil-beta-ciclodextrina para tratamento oral do fechamento do canal arterial

Rama¹,

Veiga²,

Figueiredo³

et al. 2005

Rev. Bras. Cienc. Farm.

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INTRODUÇÃOA investigação farmacêutica tem como intuito o desenvolvimento de novos agentes terapêuticos direcionados à resolução de situações clínicas, integrando conhecimentos pluridisciplinares.A prática de cuidados farmacêuticos possibilita a identificação de situações clínicas para as quais os recursos terapêuticos existentes não são os adequados. Fazer parte da equipe de saúde de uma unidade de cuidados intensivos de neonatologia é um desafio para o farmacêu-tico clínico, confrontado com a necessidade de dar resposta aos problemas biofarmacêuticos decorrentes da anatomofisiologia e das patologias inerentes àquele gru- Unitermos• Indometacina• Hidroxipropil-β-ciclodextrina• Recém-nascidos• Canal arterial

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“…Generally their solubility in water is greatly increased at higher temperatures (except for the dimethyl-b-CD which decreases). The most important characteristics of the natural CDs are summarized in Table 2 (Saenger 1980;Szejtli1998;Pitha et al 1983;Duchêne et al 1986;Bas and Rysanek 1987;Uekama and Otagiri 1987;Duchêne and Wouessidjewe 1990a;Salústio et al 2011).…”

Section: Parent Cyclodextrinsmentioning

confidence: 99%

Cyclodextrins

Couto¹,

Salústio²,

Cabral-Marques³

2014

Polysaccharides

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Cyclodextrins (CDs) were first isolated in 1891 as degradation products of starch from a medium of Bacillus amylobacter. They are cyclic water-soluble, nonreducing, macrocycle carbohydrate polymers constructed from a-(1-4)-linked D-glucopyranose units (naturally occurring a, b, and g formed by 6, 7, and 8 glucose units), in a ring formation and present a toroidal, hollow, truncated cone shape. Their most important property is the ability to establish specific interactions -molecular encapsulation -with various types of molecules through the formation of non-covalently bonded entities, either in the solid phase or in aqueous solution, taking up a whole molecule, or some part of it, into their cavities. This process in part mimics the "lock and key" mechanism of enzyme catalysis. Complexation may cause changes in physicochemical properties of the guest molecule (e.g., solubility, stability, kinetics and bioavailability, toxicity). Their negligible cytotoxic effects promoted them to the GRAS list and led them to be widely used in many industrial products and technologies.

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Cyclodextrins, Their Value in Pharmaceutical Technology

Cited by 64 publications

References 50 publications

A review on cyclodextrin encapsulation of essential oils and volatiles

A review on cyclodextrin encapsulation of essential oils and volatiles

Aspectos biofarmacêuticos da formulação de medicamentos para neonatos: fundamentos da complexação de indometacina com hidroxipropil-beta-ciclodextrina para tratamento oral do fechamento do canal arterial

Cyclodextrins

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