2022
DOI: 10.1016/j.jinorgbio.2022.111855
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Cyclometalated iridium(III) dithioformic acid complexes as mitochondria-targeted imaging and anticancer agents

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Cited by 8 publications
(6 citation statements)
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“…Overall, our studies reflect the potential of Ir2@DEDTC and Ir2@MORDTC to act as potential PSs for PDT after irradiation with blue LED (456, 30 mW/cm 2 light) against HCT116 and HeLa cancer cell lines Figures 5 and S28. In contrast to the cytotoxicity studies of iridium(III) dithiocarbamate complexes reported previously, 36 in our experiment, we have noted that on the treatment of complexes for 24 h, followed by 24 h recovery, all the complexes exhibited poor dark toxicities (due to proliferation of cells during recovery period). It is also evident that the light induced cytotoxicities of the complexes are significant even after the recovery period.…”
Section: Photophysical Propertiescontrasting
confidence: 99%
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“…Overall, our studies reflect the potential of Ir2@DEDTC and Ir2@MORDTC to act as potential PSs for PDT after irradiation with blue LED (456, 30 mW/cm 2 light) against HCT116 and HeLa cancer cell lines Figures 5 and S28. In contrast to the cytotoxicity studies of iridium(III) dithiocarbamate complexes reported previously, 36 in our experiment, we have noted that on the treatment of complexes for 24 h, followed by 24 h recovery, all the complexes exhibited poor dark toxicities (due to proliferation of cells during recovery period). It is also evident that the light induced cytotoxicities of the complexes are significant even after the recovery period.…”
Section: Photophysical Propertiescontrasting
confidence: 99%
“…Recently cationic-based Ir­(III) cyclometalated complexes have been studied as glutathione sensing agents . Also, neutral iridium­(III) complexes bearing dithioformic acid ligands were reported as mitochondria-targeted cytotoxic agents . However, the photophysical properties and their ability to act as PS for PDT have not been explored.…”
Section: Introductionmentioning
confidence: 99%
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“…For the complexation of Ir1– 68 , they performed a synthesis with 2 equiv of 67 and chloro-bridged iridium­(III) dimers. Finally, ApIrC was obtained by adding aptamer AS1411 to the Ir2– 69 complex , (Scheme ).…”
Section: Discussionmentioning
confidence: 99%
“…4 For example, iridium( iii ) dithioformic acid complexes ([(ppy) 2 Ir(S^S)]) bearing four-membered ring structures were synthesized recently. 5 These iridium( iii ) complexes show high reaction yields and good molecular stability due to the strong coordination ability between the sulfur atom and the Ir center. Moreover, the reduced S–Ir–S angle between two Ir–S bonds facilitates the progress of MLCT (metal-to-ligand charge transfer).…”
Section: Introductionmentioning
confidence: 99%