Cyclooxygenase-2 Genetic Polymorphism and Stroke Subtypes in Chinese

Chen, Guozhong; Xu, Shan; Cheng, Gan-ping; Tao, Hong-miao

doi:10.1007/s12031-013-0078-5

Cited by 16 publications

(14 citation statements)

References 28 publications

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“…Figure 2 shows that a significantly larger proportion of Chinese patients with stroke and DM have lacunar stroke compared with non-Chinese patients, whereas non-Chinese patients have a significantly higher proportion of middle cerebral artery infarctions. This supports our original notion that Chinese patients may be especially vulnerable to SVD and is consistent with findings from a study conducted in Hong Kong indicating that SVD and hemorrhages are more likely than other stroke types (22). Figure 3 shows an analysis of the frequency of SVD versus large vessel disease in our cohorts and indicates the same difference, whereby SVD is more frequent in Chinese patients with stroke and DM than in non-Chinese patients with similar diagnoses.…”

Section: Discussionsupporting

confidence: 91%

Epidemiology of Cerebrovascular Disease Among Chinese Canadian Adults With Type 2 Diabetes

Lam

Chu

2018

Canadian Journal of Diabetes

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Section: Discussionsupporting

confidence: 91%

Epidemiology of Cerebrovascular Disease Among Chinese Canadian Adults With Type 2 Diabetes

Lam

Chu

2018

Canadian Journal of Diabetes

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“…One of the research focuses is cyclooxygenase 2 (COX-2), a key enzyme in prostaglandin biosynthesis. A study showed that a COX-2 genetic polymorphism in the Chinese population may contribute to the risk of developing white matter lesions [10]. Our previous study also revealed that using COX-2 inhibitor can attenuate CSVD in an animal model [11].…”

Section: Introductionmentioning

confidence: 84%

EP3 Receptor Deficiency Attenuates Vascular Remodeling and Cognitive Impairment in a Cerebral Small Vessel Disease Model

Liu

Tang

Yang

et al. 2020

Preprint

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BackgroundAnti-hypertensive therapy has achieved effective but not complete results in treating cerebral small vessel disease (CSVD), suggesting the necessity for additional treatments. Targeting abnormal inflammatory responses has become a research interest. Inhibition of E-prostanoid 3(EP3) receptor has been shown to attenuate vascular remodeling in peripheral organs, but little is known about its role in CSVD. Here, we investigated whether the deletion of EP3 attenuates the development of CSVD.MethodsStroke-prone renovascular hypertensive rat (RHRsp) was used as an animal model of CSVD. The effect of EP3 deletion on the expression of extracellular matrix (ECM) in cerebral small arteries of RHRsp was detected by immunofluorescence. Changes in cognitive function and cerebral blood flow (CBF) of RHRsp were evaluated using the Morris water maze test and MRI. In vitro experiments with primary rat brain microvascular smooth muscle cells were used to confirm whether the transforming growth factor beta 1 (TGF-β1) signal takes part in the processResultsCerebral small arteries of RHRsp exhibited increased EP3 expression. Despite no alleviation in hypertension, the deletion of EP3 still reduced the overexpression of ECM in the cerebral small arteries of RHRsp. In vitro experiments indicated that EP3 deletion regulated the expression of ECM by downregulating TGF-β1/Smad signaling. EP3 knockout further attenuated the cognitive impairment of the RHRsp possibly through increased CBF. ConclusionTogether, our results indicate that the deletion of EP3 attenuates the vascular remodeling and vascular cognitive impairment induced by hypertension, and blockade of the EP3 receptor may be a promising strategy for the treatment of CSVD.

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“…It has been shown that the COX-2-765G>C polymorphism is a protective factor against ischemic stroke in Italians [34], but the association between COX-2-765G>C and ischemic stroke and leukoaraiosis could not be replicated in Chinese [27,38] and Koreans [39]. As for COX-2-8473T>C, Maguire et al [40] demonstrated a significant effect of the COX-2-8473T>C polymorphisms on ischemic stroke functional outcome in Australians, while no association between the COX-2-8473T>C polymorphisms and intracerebral hemorrhage was observed in Koreans [41].…”

Section: Plos Onementioning

confidence: 99%

“…Reportedly, the COX-2-8473 C>T polymorphism has an effect on COX-2 mRNA and protein levels [19], the COX-2-765 G>C polymorphism might modify COX-2 mRNA [20], and the COX-2-1759 G>A polymorphism can influence COX-2 activity [24]. In addition, these SNPs have been demonstrated to be associated with several diseases involving COX-2, including bronchial asthma [23], coronary artery disease [25], cerebral infarction [26], and stroke [27].…”

Section: Introductionmentioning

confidence: 99%

Association of the cyclooxygenase-2 1759A allele with migraine in Chinese Han individuals

et al. 2020

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Cyclooxygenase-2 (COX-2) is known to be involved in the pathogenesis of migraine, and some polymorphisms are known to affect the expression of COX-2. This retrospective casecontrol study aimed to explore the associations between the-765 G>C (rs20417),-1759 G>A (rs3218625), and-8473 C>T (rs5275) COX-2 polymorphisms and migraine in Chinese Han individuals. One hundred and ten unrelated Han Chinese patients with migraine and 108 healthy controls were recruited between 03/2014 and 08/2016 at the First Affiliated Hospital of Nanjing Medical University and the First People's Hospital of Lianyungang City. The genotypes of all polymorphisms in controls followed the Hardy-Weinberg equilibrium (P = 0.215, P = 0.884, and P = 0.689). There were differences in the genotype and allele distributions of the COX-2-1759G>A (Gly587Arg) polymorphism between the migraine and control groups (P = 0.038 and P = 0.040, respectively). Compared with the COX-2-1759AG genotype, GG genotype carriers had an increased risk of migraine (odds ratio (OR) = 8.720, 95% confidence interval (CI): 1.072-70.960, P = 0.038). The frequency of the COX-2-1759A allele in patients with migraine was significantly lower than the controls (OR = 0.119, 95%CI: 0.015-0.957, P = 0.040). Adjusted age and sex, a statistical difference was found in the dominant model of COX-2-1759 G>A (OR = 0.118, 95% CI 0.014 to 0.962, P = 0.046). No significant difference was detected regarding the-765G>C and-8473T>C polymorphisms between the two groups. The COX-2 1759A allele might be involved in the development of migraine in Chinese Han individuals, but this will have to be confirmed in large-scale studies.

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Cyclooxygenase-2 Genetic Polymorphism and Stroke Subtypes in Chinese

Abstract: In conclusion, we found that -1195G>A polymorphism and A-1195-G-765 haplotype of COX-2 were associated with susceptibility to ischemic stroke in a Chinese population. The effects were confined to SVO among the stroke subtypes rather than to LAA.

Cited by 16 publications

References 28 publications

Epidemiology of Cerebrovascular Disease Among Chinese Canadian Adults With Type 2 Diabetes

Epidemiology of Cerebrovascular Disease Among Chinese Canadian Adults With Type 2 Diabetes

EP3 Receptor Deficiency Attenuates Vascular Remodeling and Cognitive Impairment in a Cerebral Small Vessel Disease Model

Association of the cyclooxygenase-2 1759A allele with migraine in Chinese Han individuals

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