Cyclooxygenase (COX)-1 and -2 Inhibitory Labdane Diterpenes from <i>Crassocephalum mannii</i>

Hegazy, Mohamed‐Elamir F.; Ohta, Shigeru; Abdel-Latif, F. F.; Albadry, Hazem A.; Ohta, Emi; Paré, Paul W.; Hirata, Toshifumi

doi:10.1021/np800017x

Cited by 12 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two compds. Anti-cyclooxygenases (Hegazy, et al, 2008) Cryptococcus neoformans (Kita, et al, 2007a) Elsholtzia rugulosa Protein toxin TOF Genetics of biosynthesis (Nolan, et al, 2007) Lethasterias fusca (Far Easterm starfish)…”

Section: Labdane Diterpene Glycosides Tof Nmr Hplcmentioning

confidence: 99%

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2007–2008

Harvey

2011

Mass Spectrometry Reviews

View full text Add to dashboard Cite

This review is the fifth update of the original review, published in 1999, on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2008. The first section of the review covers fundamental studies, fragmentation of carbohydrate ions, use of derivatives and new software developments for analysis of carbohydrate spectra. Among newer areas of method development are glycan arrays, MALDI imaging and the use of ion mobility spectrometry. The second section of the review discusses applications of MALDI MS to the analysis of different types of carbohydrate. Specific compound classes that are covered include carbohydrate polymers from plants, N- and O-linked glycans from glycoproteins, biopharmaceuticals, glycated proteins, glycolipids, glycosides and various other natural products. There is a short section on the use of MALDI mass spectrometry for the study of enzymes involved in glycan processing and a section on the use of MALDI MS to monitor products of the chemical synthesis of carbohydrates with emphasis on carbohydrate-protein complexes and glycodendrimers. Corresponding analyses by electrospray ionization now appear to outnumber those performed by MALDI and the amount of literature makes a comprehensive review on this technique impractical. However, most of the work relating to sample preparation and glycan synthesis is equally relevant to electrospray and, consequently, those proposing analyses by electrospray should also find material in this review of interest.

show abstract

Section: Labdane Diterpene Glycosides Tof Nmr Hplcmentioning

confidence: 99%

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2007–2008

Harvey

2011

Mass Spectrometry Reviews

View full text Add to dashboard Cite

show abstract

“…Therefore, after isolation, it is crucial to understand the pharmacological properties of these plant-based compounds. Previous studies have identified several plant-derived compounds, including labdane [9, diterpenes, capable to inhibit COX-1 and/or COX-2 13] . In the present work, three diterpenoids isolated from P. ornatus were evaluated for a potential COX-1 inhibitory effect, using a functional assay, based in the peroxidase component of COX.…”

Section: Discussionmentioning

confidence: 99%

“…Assim, após isolamento, é fundamental compreender as propriedades farmacológicas de compostos derivados de plantas. Estudos anteriores identificaram diversos compostos derivados de plantas, incluindo diterpenos com esqueleto de labdano, com capacidade de inibir a [9,13] COX-1 e/ou a COX-2…”

Section: Discussionunclassified

Evaluation of diterpenoids from P. ornatus as potential COX-1 inhibitors

Rijo

Fernandes

Simões

et al. 2012

BBR

View full text Add to dashboard Cite

Natural products are a rich source of drug candidates for clinical use. The Plectranthus ornatus Codd. belongs to a genus associated to the isolation of diterpenoids which are responsible for various biological activities. The three diterpenoids under study were isolated in the past from P. ornatus and are now being evaluated as potential COX-1 inhibitors. Obtained results suggest that rhinocerotinoic acid (2), but not halimane (3) and plectrornatin C (1), has a mild COX-1 inhibitory activity. Current studies are being carried out to understand if these compounds have effect as COX-2 inhibitors. This will contribute to establish their possible interest as anti-inflammatory agents.

show abstract

“…Phytochemical screening indicated A. membranaceum to contain mainly triterpenoids and alkaloids while C. manii contains mainly triterpenoids. The literature indicated that these classes of compounds are widely reported from these genera displaying different biological activities (Bringmann et al, 2000;Chhabra et al, 1984;Hegazy et al, 2008;Steenkamp et al, 2009). Comparing the activities of extracts six medicinal plants under this investigation and the standard antibiotics, Ciprofloxacin had much higher activities than all plant extracts.…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Anti-Mycobacterial and Toxicity Activities of Some Priority Medicinal Plants from Lake Victoria Basin, Tanzania

Magadula

2012

EJMP

View full text Add to dashboard Cite

show abstract

Cyclooxygenase (COX)-1 and -2 Inhibitory Labdane Diterpenes from Crassocephalum mannii

Cited by 12 publications

References 22 publications

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2007–2008

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2007–2008

Evaluation of diterpenoids from P. ornatus as potential COX-1 inhibitors

Anti-Mycobacterial and Toxicity Activities of Some Priority Medicinal Plants from Lake Victoria Basin, Tanzania

Contact Info

Product

Resources

About