2008
DOI: 10.1096/fj.08-108159
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Cyclooxygenases 1 and 2 contribute to peroxynitrite‐mediated inflammatory pain hypersensitivity

Abstract: Peroxynitrite (ONOO(-)), the reaction product of the interaction between superoxide (O(2)(*-)) and nitric oxide (*NO), is a potent proinflammatory and cytotoxic nitrooxidative species. Its role as a mediator of hyperalgesia (clinically defined as an augmented sensitivity to painful stimuli) is not known. In light of the known proinflammatory properties of ONOO(-), our study addressed its potential involvement in the development of hyperalgesia associated with tissue damage and inflammation. Intraplantar inject… Show more

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Cited by 82 publications
(96 citation statements)
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“…•-is important to the development of thermal hyperalgesia associated with acute and chronic inflammation [10,37]; and promotes mechanical hyperalgesia [11]. Accordingly, treatment with Tempol (SOD mimetic) inhibited the hyperalgesia and inflammation in carrageenan-induced pain [38].…”
Section: Discussionmentioning
confidence: 99%
“…•-is important to the development of thermal hyperalgesia associated with acute and chronic inflammation [10,37]; and promotes mechanical hyperalgesia [11]. Accordingly, treatment with Tempol (SOD mimetic) inhibited the hyperalgesia and inflammation in carrageenan-induced pain [38].…”
Section: Discussionmentioning
confidence: 99%
“…Possibly relevant for the pronociceptive actions of NO, this radical is known to react with superoxide anion to produce peroxynitrite that was shown to evoke heat hyperalgesia accompanied by signs of inflammation upon intraplantar administration in rats (530). Moreover, applied superoxide alone induced hyperalgesia that was blocked by NOS inhibition, suggesting that endogenous NO was required to form hyperalgesic peroxynitrite.…”
Section: Mechanisms Of Peripheral Pronociceptive Actions Of Nitric Oxidementioning
confidence: 99%
“…During inflammation, the redox environment surrounding the cells changes due to rapid production of reactive oxygen species. Increased levels of reactive oxygen species are implicated in the etiology of inflammatory hyperalgesia (14,(21)(22)(23)(24). Importantly, TRPV1 was found to be responsible for long sustained thermal hypersensitivity in inflammatory hyperalgesia induced by increased levels of hydrogen peroxide (H 2 O 2 ) (25).…”
mentioning
confidence: 99%