Cyclophilin A produced by thymocytes regulates the migration of murine bone marrow cells

Toxoplasma gondiiCyclophilin 18 Regulates the Proliferation and Migration of Murine Macrophages and Spleen Cells

“…Moreover, TgCyp18, which is similar in action to MIP-1␤, which binds CCR5, can attract mouse DCs in vitro (3). Furthermore, it has been reported that the secretory form of CypA possesses chemotactic activity, regulating the migration of DCs, monocytes, neutrophils, eosinophils, B lymphocytes, and T lymphocytes through its interaction with CD147, a type I transmembrane glycoprotein (13,26,41,44). Our study showed that TgCyp18 elicited macrophage and spleen cell migration in a dose-and CCR5-dependent fashion.…”

Basigin Mediates Pulmonary Hypertension by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation

“…24 The chemotactic activities of extracellular CyPA depend on Bsg, which serves as the primary binding site for CyPA on target cells. 25 Inflammation is augmented by cytokines/chemokines and growth factors secreted from perivascular inflammatory cells.…”

Differential Expression of Cyclophilin A and EMMPRIN in Developing Molars of Rats

“…The secreted form of Cyp-A is a potent chemoattractant for macrophage colony-stimulating factor (MCSF)-dependant macrophages (Comalada et al, 2003;Sà nchez-Tilló et al, 2006), monocytes (Galat, 1993;Payeli et al, 2008), neutrophils (Sherry et al, 1992), eosinophils (Xu et al, 1992), and T cells (Kasinrerk, 1999). This molecule is involved in the adhesion of monocytes/macrophages to the extracellular matrix (Yang et al, 2008) and the migration of murine bone marrow cells (Khromykh et al, 2007). In addition, the secreted form modulates osteoblastic activity (Andersen et al, 2003) as well as the functions of endothelial cells via paracrine and autocrine modes (Kim et al, 2004).…”