Cycloserine induced mania

Bakhla, Ajay Kumar; Gore, P.S.; Srivastava, Sanjay

doi:10.4103/0972-6748.123636

Cited by 14 publications

(18 citation statements)

References 8 publications

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“…However, possible modulation of N-methyl-D-aspartate receptor (NMDAR) antagonists and partial agonist at NMDAR associated glycine site by the drug as proposed by Bakhla et al . [ 4 ] may be the possible mechanism, in this case. The current case further supports this hypothesis since aggression and insomnia suggests a CNS stimulant action of the drug although no seizures were observed in our patient.…”

Section: Discussionmentioning

confidence: 97%

“…While, mania was the main presentation reported by Bakhla et al . [ 4 ] and seizure with psychosis in the case reported by Fujita et al . [ 5 ] Unlike above cases our patient was aggressive, violent, restlessness, anxious and presented with insomnia and had severe hepatic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 2 ] Few reports of cycloserine induced psychiatric disorders like delusions and hallucinations, mania and associated seizures are available. [ 3 4 5 ]…”

Section: Introductionmentioning

confidence: 99%

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Cycloserine induced psychosis with hepatic dysfunction

et al. 2015

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With the increase in the cases of multidrug resistance tuberculosis, second line anti-tubercular drugs like the cycloserine are being prescribed frequently. Isoniazid and ethambutol are reported to cause psychosis like state; however, few reports of cycloserine induced psychosis are available. To the best of our knowledge, this is the first case of cycloserine induced psychosis with hepatic dysfunction.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Cycloserine induced psychosis with hepatic dysfunction

et al. 2015

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“…In cases reported in the literature, terminating cycloserine alone or together with the use of anti-manic anti-psychotic agents has caused the manic/psychotic profile to regress in a short time, and anti-manic anti-psychotic treatment for a short time has been reported to be sufficient 3,4,5,6,7 .…”

Section: Discussionmentioning

confidence: 99%

Sikloserin ile ilişkili mani

Çakmak¹,

Bal²,

Gelegen³

et al. 2016

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

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AbstractÖz Cycloserine is a broad spectrum antibiotic agent commonly used as a second-line treatment for patients with multi-drug resistant pulmonary and extrapulmonary tuberculosis and associated with many neuropsychiatric adverse events. Mania is rarely reported in this context. We report a case of 38-year-old male diagnosed as Pott disease and developed manic symptoms while on second line anti-tubercular treatment for multi-drug resistant pulmonary and extrapulmonary tuberculosis. We related these manic symptoms with cycloserine. The patient remitted significantly in one week period after discontinuation of cycloserine and initiation of antipsychotic treatment. This case emphasizes that manic switch or exacerbation of psychosis can occur in early or late stage of treatment and that the necessity of periodic psychiatric evaluation before and during the treatment.Sikloserin, çoklu ilaç direnci olan akciğer ve akciğer dışı tüberkülozlarda ikinci basamak tedavide sık kullanılan geniş spektrumlu bir antibiyotik ajandır. Birçok nöropsikiyatrik yan etki ile ilişkilendirilmektedir. Yan etkileri arasında nadir olmakla birlikte mani ile ilişkilendirilen olgular da bulunmaktadır. Bu olguya Pott hastalığı tanısı konulmuş ve çoklu ilaç direnci olan akciğer ve akciğer dışı tüberküloz olarak tanımlanmış, tedavisinde sikloserin kullanılmış olan 38 yaşında bir erkek hasta tartışılmıştır. Tedavi sürecinde mani gelişmiş ve sikloserin ile ilişkili olabileceği düşünülmüştür. Mani bulguları ilacın kesilmesi ve antipsikotik medikasyonla 1 haftalık süreçte gerilemiştir. Bu olgu bildirimi ile sikloserin kullanımında mani ve psikotik bulguların tedavinin erken veya geç aşamalarında ortaya çıkabileceği, tedavi öncesi ve tedavi devam etmekte iken psikiyatrik değerlendirmelerin düzenli aralıklara yapılması gerekliliği vurgulanmıştır.

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“…Cabe anotar que el brote de psicosis inducida por cicloserina no es necesariamente inmediato: en la literatura se reportan casos suscitados luego de varios meses de iniciado el uso de cicloserina (2,7). Para mayor abundamiento, la evaluación de este caso a la luz del Algoritmo de Naranjo, uno de los más empleados en la ponderación de efectos adversos medicamentosos, arroja un puntaje de 7; lo que califica como "probable" la adjudicación de nuestro caso de psicosis a los efectos de la cicloserina (12). Aunque hay algunos reportes de caso de psicosis secundaria a la administración de ciprofloxacino (5), la desaparición de la psicosis en nuestro caso pese a la continuación de este inhibidor de girasa, descarta su participación causal; lo mismo puede decirse del etambutol, cuya participación en casos de psicosis es aún más infrecuente (5,6).…”

Section: Correspondenciaunclassified

Psicosis inducida por fármacos antituberculosos: un caso asociado a cicloserina.

Arias-Gutiérrez¹,

Cabrejos-Novoa²,

Núñez-Moscoso³

et al. 2014

Rev Neuropsiquiatr

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RESUMENNuestro país posee una alta prevalencia e incidencia de casos de tuberculosis (para el año 2012 se registró una morbilidad de 105,2 casos por 100 000 habitantes). En el tratamiento de esta patología pueden desencadenarse numerosas reacciones adversas de índole heterogénea, siendo preponderantes las neuropsiquiátricas, por la polifarmacia antibiótica requerida y otros posibles factores de riesgo del usuario. A partir de un caso de psicosis desencadenada por cicloserina en un paciente con tuberculosis multidrogorresistente, revisamos la literatura pertinente y recomendamos la ponderación individualizada del retiro de la medicación desencadenante del efecto adverso, respecto a la necesidad de mantener la cobertura antibiótica imprescindible y adecuada. PALABRAS CLAVE:Cicloserina, Tuberculosis Resistente a Múltiples Medicamentos, Psicosis Inducida por Sustancias, Efectos Colaterales y Reacciones Adversas Relacionadas con Medicamentos. SUMMARYOur country has a high prevalence of tuberculosis (morbidity in year 2012 was 105,2 cases per 100 000 people). In the treatment of this disease, a high number of diverse drug-related side-effects, with prevalent neuropsychiatric type, can be developed, because of the antibiotic polypharmacy required and other possible risk factors. From a case of cycloserine-induced psychosis, in a patient with multidrug-resistant tuberculosis, we review the relevant literature and recommend individualized consideration on the withdrawal of the side-effect trigger medication versus the need to maintain the essential and appropriate antibiotic coverage.

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Cycloserine induced mania

Cited by 14 publications

References 8 publications

Cycloserine induced psychosis with hepatic dysfunction

Cycloserine induced psychosis with hepatic dysfunction

Sikloserin ile ilişkili mani

Psicosis inducida por fármacos antituberculosos: un caso asociado a cicloserina.

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