Cyclosporine A Delivery Platform for Veterinary Ophthalmology—A New Concept for Advanced Ophthalmology

Padjasek, Martyna; Qasem, Badr; Cislo-Pakuluk, Anna; Marycz, Krzysztof

doi:10.3390/biom12101525

Cited by 10 publications

(5 citation statements)

References 88 publications

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“…59 Based on the values obtained in Figure 6, the sample composed only of electrospun PLDLA presented a contact angle measurement with distilled water of 130 (± 2.2 ), confirming its hydrophobic character. Contrary to previous observations, Padjasek et al 61 and Zych et al 62 indicated that PLDLA film samples exhibit contact angles of approximately 70.9 (± 2.1 ) and 75.5 (± 3.6 ), respectively. Similar results were observed by Wimpenny, Ashammakhi, and Yang, 63 where the PLDLA film presented a less hydrophobic character compared with the electrospun material.…”

Section: Contact Angle Measurementmentioning

confidence: 62%

Development of co‐electrospun membrane composed poly(l‐co‐d,l‐lactic acid) and natural rubber with potential application in dermal dressing

Pinto,

V. Quevedo,

Komatsu

et al. 2024

J of Applied Polymer Sci

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Wound healing represents a global challenge for the healthcare system, resulting in substantial costs and physical and emotional impacts on individuals. There is an increasing demand for innovative alternatives to treat this condition. The co‐electrospinning technique enables the production of porous membrane composed of natural and synthetic polymers, which exhibit unique functions and adjustable mechanical properties that assist in the tissue healing process. Therefore, the present study aims to investigate the physical–chemical, mechanical, and biological properties of membrane composed of poly(l‐co‐d,l‐lactic acid) (PLDLA) co‐electrospun with different concentrations of natural rubber (NR) (1.5%, 2.0%, and 2.5%). Scanning electron microscopy analysis revealed the porous surface of the membranes. Fourier‐transform infrared spectroscopy confirmed the presence of NR in the material. The low Young's modulus obtained in the mechanical tensile test for the PLDLA membrane co‐electrospun with 1.5% NR indicated its elastic capacity under low tension. The results corroborate with the differential scanning calorimetry, and thermogravimetric analysis, which highlights the compatibility between polymers at this specific proportion, as well as in vitro biocompatibility. The findings underscore the potential of PLDLA and NR co‐electrospun membranes as promising candidates for formulating biomaterials for applications such as dermal dressings.

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Section: Contact Angle Measurementmentioning

confidence: 62%

Development of co‐electrospun membrane composed poly(l‐co‐d,l‐lactic acid) and natural rubber with potential application in dermal dressing

Pinto,

V. Quevedo,

Komatsu

et al. 2024

J of Applied Polymer Sci

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“…CsA is a lipophilic, cyclic undecapeptide weighing 1202.6 g/mol MW, with poor solubility in water and limited bioavailability [ 10 ]. As a drug, it is used in human and veterinary medicine transplantation procedures as well as the broad spectrum of immune-mediated inflammatory diseases (IMIDs) due to its strong immunosuppressive potency [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

PLDLA/TPU Matrix Enriched with Cyclosporine A as a Therapeutic Platform for Immune-Mediated Keratitis (IMMK) in Horses

Padjasek

Cisło-Sankowska

Lis-Bartos

et al. 2023

IJMS

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The purpose of this study was to describe the use of PLDLA/TPU matrix enriched with cyclosporine A (CsA) as a therapeutic platform in horses with immune-mediated keratitis (IMMK) with an in vitro evaluation CsA release and degradation of the blend as well as determination of the safety and efficacy of that platform used in the animal model. The kinetics of the CsA release from matrices constructed of thermoplastic polyurethane (TPU) polymer and a copolymer of L-lactide with DL-lactide (PLDLA) (80:20) in the TPU (10%) and a PLDL (90%) polymer blend were studied. Moreover, we used the STF (Simulated Tear Fluid) at 37 °C as a biological environment to assess the CsA release and its degradation. Additionally, the platform described above was injected subconjunctival in the dorsolateral quadrant of the globe after standing sedation of horses with diagnosed superficial and mid-stromal IMMK. The obtained results indicated that the CsA release rate in the fifth week of the study increased significantly by the value of 0.3% compared to previous weeks. In all of the cases, the TPU/PLA doped with 12 mg of the CsA platform effectively reduced the clinical symptoms of keratitis, leading to the complete remission of the corneal opacity and infiltration four weeks post-injection. The results from this study showed that the PLDLA/TPU matrix enriched with the CsA platform was well tolerated by the equine model and effective in treating superficial and mid-stromal IMMK.

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“…Cyclosporin A is a selective and reversible immunosuppressive agent that is widely used as a drug for a wide spectrum of human diseases, such as graft-versus-host disease, noninfectious uveitis, rheumatoid arthritis, psoriasis, and atopic dermatitis [10]. Clinically, the gingival lesion induced by ciclosporin A is characterized by hyperemia, bleeding both during probing and brushing, or even spontaneous bleeding.…”

Section: Introductionmentioning

confidence: 99%

Implications of bacterial plaque in gingival overgrowth induced by orthodontic therapy

Andrei

2023

JCIMCR

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Cyclosporine A Delivery Platform for Veterinary Ophthalmology—A New Concept for Advanced Ophthalmology

Cited by 10 publications

References 88 publications

Development of co‐electrospun membrane composed poly(l‐co‐d,l‐lactic acid) and natural rubber with potential application in dermal dressing

Development of co‐electrospun membrane composed poly(l‐co‐d,l‐lactic acid) and natural rubber with potential application in dermal dressing

PLDLA/TPU Matrix Enriched with Cyclosporine A as a Therapeutic Platform for Immune-Mediated Keratitis (IMMK) in Horses

Implications of bacterial plaque in gingival overgrowth induced by orthodontic therapy

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