Cylindrical agar gel with fluid flow subjected to an alternating magnetic field during hyperthermia

Javidi, Mehrdad; Heydari, Mohammad Mehdi; Attar, Mohammad Mahdi; Haghpanahi, Mohammad; Karimi, Alireza; Navidbakhsh, Mahdi; Amanpour, Saeid

doi:10.3109/02656736.2014.988661

Cited by 24 publications

(10 citation statements)

References 36 publications

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“…56,57 As stated above, the Casson equation agrees well only when the shear rate is less than 10 s À1 . 40,53-55 Blood is a complex non-Newtonian°uid, whose property can be described by the Casson equation only when shear rate is lower than 10 s À1 .…”

Section: Governing Equations and Numerical Modelmentioning

confidence: 58%

A Numerical Study on the Hemodynamic and Shear Stress of Double Aneurysm Through S-Shaped Vessel

Halabian

Karimi

Beigzadeh

et al. 2015

Biomed. Eng. Appl. Basis Commun.

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Abdominal aortic aneurysm (AAA) is a degenerative disease de¯ned as the abnormal ballooning of the abdominal aorta (AA) wall which is usually caused by atherosclerosis. The aneurysm grows larger and eventually ruptures if it is not diagnosed and treated. Aneurysms occur mostly in the aorta, the main artery of the chest and abdomen. The aorta carries blood°ow from the heart to all parts of the body, including the vital organs, the legs, and feet. The objective of the present study is to investigate the combined e®ects of aneurysm and curvature on°ow characteristics in S-shaped bends with sweep angle of 90 at Reynolds number of 900. The°uid mechanics of blood°ow in a curved artery with abnormal aortic is studied through a mathematical analysis and employing Cosmos°ow simulation. Blood is modeled as an incompressible non-Newtonian°uid and the°ow is assumed to be steady and laminar. Hemodynamic characteristics are analyzed. Grid independence is tested on three successively re¯ned meshes. It is observed that the abrupt expansion induced by AAA results in an immensely disturbed regime. The results may have implications not only for understanding the mechanical behavior of the blood°ow inside an aneurysm artery but also for investigating the mechanical behavior of the blood°ow in di®erent arterial diseases, such as atherosclerosis.

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Section: Governing Equations and Numerical Modelmentioning

confidence: 58%

A Numerical Study on the Hemodynamic and Shear Stress of Double Aneurysm Through S-Shaped Vessel

Halabian

Karimi

Beigzadeh

et al. 2015

Biomed. Eng. Appl. Basis Commun.

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“…The only group which was able to kill some of the fibroblast cells was the DMNPs group. Although the uptakes of MNP and DMNP groups were not significantly different for SKBR3 and fibroblast cells, cytotoxicity was higher for cancer cells due to more sensitivity of the cancer cells to high temperatures (Javidi et al 2015 ). Finally, the ADMNPs group with excellent targeting ability and good temperature elevation under AFM was able to kill over 65 percent of cancerous cells without affecting normal fibroblast cells.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and application of magnetite dextran-spermine nanoparticles in breast cancer hyperthermia

et al. 2017

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Cancer treatment has been very challenging in recent decades. One of the most promising cancer treatment methods is hyperthermia, which increases the tumor temperature (41–45 °C). Magnetic nanoparticles have been widely used for selective targeting of cancer cells. In the present study, magnetic dextran-spermine nanoparticles, conjugated with Anti-HER2 antibody to target breast cancer cells were developed. The magnetic dextran-spermine nanoparticles (DMNPs) were prepared by ionic gelation, followed by conjugation of antibody to them using EDC-NHS method. Then the Prussian blue method was used to estimate the targeting ability and cellular uptake. Cytotoxicity assay by MTT showed that antibody-conjugated MNPs (ADMNPs) have no toxic effect on SKBR3 and human fibroblast cells. Finally, the hyperthermia was applied to show that synthesized ADMNPs, could increase the cancer cells temperature up to 45 °C and kill most of them without affecting normal cells. These observations proved that Anti-HER2 conjugated magnetic dextran-spermine nanoparticles can target and destroy cancer cells and are potentially suitable for cancer treatment.

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“…Hence, the heat generated by nanoparticle transfers with the blood flow3031. In case of the microwires, however, they can be directly inserted into a tumor area, so this problem can be avoided.…”

Section: Resultsmentioning

confidence: 99%

Ferromagnetic glass-coated microwires with good heating properties for magnetic hyperthermia

Talaat

Alonso

Zhukova

et al. 2016

Sci Rep

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The heating properties of Fe71.7Si11B13.4Nb3Ni0.9 amorphous glass-coated microwires are explored for prospective applications in magnetic hyperthermia. We show that a single 5 mm long wire is able to produce a sufficient amount of heat, with the specific loss power (SLP) reaching a value as high as 521 W/g for an AC field of 700 Oe and a frequency of 310 kHz. The large SLP is attributed to the rectangular hysteresis loop resulting from a peculiar domain structure of the microwire. For an array of parallel microwires, we have observed an SLP improvement by one order of magnitude; 950 W/g for an AC field of 700 Oe. The magnetostatic interaction strength essential in the array of wires can be manipulated by varying the distance between the wires, showing a decreasing trend in SLP with increasing wire separation. The largest SLP is obtained when the wires are aligned along the direction of the AC field. The origin of the large SLP and relevant heating mechanisms are discussed.

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Cylindrical agar gel with fluid flow subjected to an alternating magnetic field during hyperthermia

Abstract: It is believed that the proposed model has the potential ability to get close to reality in this type of investigation. The proposed function has implications for use in further modelling studies as a heat generation source.

Cited by 24 publications

References 36 publications

A Numerical Study on the Hemodynamic and Shear Stress of Double Aneurysm Through S-Shaped Vessel

A Numerical Study on the Hemodynamic and Shear Stress of Double Aneurysm Through S-Shaped Vessel

Synthesis and application of magnetite dextran-spermine nanoparticles in breast cancer hyperthermia

Ferromagnetic glass-coated microwires with good heating properties for magnetic hyperthermia

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