CYP3A4 gene polymorphism is correlated with individual consumption of sufentanil

Lv, Jidong; Liu, F.; Feng, Ning‐Ning; Sun, Xuying; Tang, Jie; Xie, Ling; Wang, Y.

doi:10.1111/aas.13178

Cited by 17 publications

(17 citation statements)

References 34 publications

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“…Although, oxycodone (a 4,5‐epoxymorphinan) is O‐dealkylated by CYP2D6, its N‐dealkylation is catalyzed primarily by CYP3A4 (c.f., Drewes et al) . A single nucleotide polymorphism (CYP3A4*1G) is reported to affect the enzymatic activity of CYP3A4 and reduce plasma drug levels . Of high relevance to this study, humans heterozygous for the CYP3A4*1G allele exhibited lower intravenous self‐administration of sufentanil (a fentanyl derivate) for pain management .…”

Section: Discussionmentioning

confidence: 77%

“…A single nucleotide polymorphism (CYP3A4*1G) is reported to affect the enzymatic activity of CYP3A4 and reduce plasma drug levels . Of high relevance to this study, humans heterozygous for the CYP3A4*1G allele exhibited lower intravenous self‐administration of sufentanil (a fentanyl derivate) for pain management . Although it remains to be determined how polymorphisms in CYP3A4 might relate to the propensity to consume opioids in uninjured individuals, the rs4646440 and rs2242480 polymorphisms in CYP3A4 are associated with greater withdrawal severity during methadone maintenance therapy .…”

Section: Discussionmentioning

confidence: 92%

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Who is HOT and who is LOT? Detailed characterization of prescription opioid‐induced changes in behavior between 129P3/J and 129S1/SvlmJ mouse substrains

Szumlinski

Coelho

Tran

et al. 2019

Genes Brain and Behavior

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Genetic factors are theorized to contribute to the substantial inter-individual variability in opioid abuse/addiction. To advance the behavioral genetics of prescription opioid abuse, our prior work identified the 129S1/SvlmJ (S1) and related 129P3/J (P3) mouse substrains, respectively, as low and high opioid-taking. Herein, we related our prior results to measures of sucrose reward/reinforcement, basal anxiety, opioidinduced place-conditioning, locomotor activity and Straub tail reaction, as well as behavioral and physiological signs of withdrawal. Substrains were also re-examined for higher-dose oxycodone and fentanyl intake under limited-access drinking procedures. S1 mice failed to acquire sucrose self-administration under various operantconditioning procedures and exhibited lower sucrose intake in the home-cage.However, sucrose intake under limited-access procedures escalated in both substrains with repeated sucrose experience. S1 mice exhibited less spontaneous locomotor activity, as well as less opioid-induced locomotor activity and Straub tail reaction, than P3 mice and failed to exhibit an oxycodone-induced place-preference.The lack of conditioned behavior by S1 mice was unrelated to behavioral signs of withdrawal-induced negative affect or dependence severity, but might reflect high levels of basal anxiety-like behavior. Intriguingly, S1 and P3 mice initially exhibited equivalent oxycodone and fentanyl consumption in the home-cage; however opioid intake escalated only in P3 mice with repeated opioid experience. No sex differences were observed for any of our measures. These data provide additional evidence for robust differences in opioid addiction-related behaviors between P3 and S1 substrains and suggest that anxiety, learning, and/or motivational impairments might confound interpretation of operant-and place-conditioning studies employing the S1 substrain. K E Y W O R D Sdependence, fentanyl, negative affect, oxycodone, self-administration, strain differences, withdrawal

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 92%

Who is HOT and who is LOT? Detailed characterization of prescription opioid‐induced changes in behavior between 129P3/J and 129S1/SvlmJ mouse substrains

Szumlinski

Coelho

Tran

et al. 2019

Genes Brain and Behavior

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“…Sufentanil is oxidized and metabolized by CYP3A4. [7][8][9][10] Catechol-O-Methyltransferase (COMT) is catecholamine main metabolic enzymes in vivo and it is used to control body to produce dopamine, which is involved in sufentanil metabolism. 11 The μ-opioid receptor 1 (OPRM1) encodes opioid receptor.…”

Section: Introductionmentioning

confidence: 99%

Establishment of predicting equation for individual sufentanil dosage postoperatively based on gene polymorphisms

et al. 2021

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“…A new multicenter, open-label, randomized controlled trial confirmed that RPCA is superior to pethidine for alleviating labor pain without serious adverse events [13]. Due to genetic polymorphisms, there are differences in not only opioid consumption but also in individual sensitivity to pain [26,27]. If the individual genetic polymorphism is identified before administering opioids, intravenous remifentanil analgesia should yield better satisfaction with labor pain relief.…”

Section: Discussionmentioning

confidence: 99%

Remifentanil patient-controlled versus epidural analgesia on intrapartum maternal fever: a systematic review and meta-analysis

Yao

Chen

et al. 2020

BMC Pregnancy Childbirth

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Background: Intravenous remifentanil patient-controlled analgesia (RPCA) is an alternative for epidural analgesia (EA) in labor pain relief. However, it remains unknown whether RPCA is superior to EA in decreasing the risk of intrapartum maternal fever during labor. Methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review and meta-analysis was performed by searching PubMed, EMBASE and the Cochrane Central Register of Controlled Trials from inception to April 2019. All randomized controlled trials (RCTs) investigating the risk of intrapartum maternal fever with RPCA compared with EA alone or EA in combination with spinal analgesia during labor were included. Results: A total of 825 studies were screened, and 6 RCTs including 3341 patients were identified. Compared with EA, RPCA was associated with a significantly lower incidence of intrapartum maternal fever (risk ratio [RR] 0.48, P = 0.02, I 2 = 49%) during labor analgesia. After excluding 2 trials via the heterogeneity analysis, there was no difference in the incidence of intrapartum fever between patients receiving RPCA and those receiving EA. Satisfaction with pain relief during labor was lower in the RPCA group than that in the EA group (− 10.6 [13.87, − 7.44], P < 0.00001, I 2 = 0%). The incidence of respiratory depression was significantly greater in the RPCA group than that in the EA group (risk ratio 2.86 [1.65, 4.96], P = 0.0002, I 2 = 58%). The incidence of Apgar scores < 7 at 5 min in the RPCA group was equivalent to that in the EA group. Conclusion: There is no solid evidence to illustrate that the incidence of intrapartum maternal fever is lower in patients receiving intravenous RPCA than in patients receiving EA.

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CYP3A4 gene polymorphism is correlated with individual consumption of sufentanil

Abstract: In summary, we found a correlation between CYP3A4 genetic polymorphism and sufentanil consumption. This might be helpful for optimizing the anesthesia strategies and reducing their side effects.

Cited by 17 publications

References 34 publications

Who is HOT and who is LOT? Detailed characterization of prescription opioid‐induced changes in behavior between 129P3/J and 129S1/SvlmJ mouse substrains

Who is HOT and who is LOT? Detailed characterization of prescription opioid‐induced changes in behavior between 129P3/J and 129S1/SvlmJ mouse substrains

Establishment of predicting equation for individual sufentanil dosage postoperatively based on gene polymorphisms

Remifentanil patient-controlled versus epidural analgesia on intrapartum maternal fever: a systematic review and meta-analysis

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