Cypermethrin Toxicity: A Review

Yadav, Bhuvnesh

doi:10.19080/jfsci.2018.09.555767

Cited by 21 publications

(8 citation statements)

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“…In this study, we used CYP pesticide due to its wide use for agricultural and household purposes, the easy accessibility of this pesticide with increased risk of suicidal, homicidal, and accidental performances, its persistence in the air and on surfaces for about 3 months, and the absence of antidote that makes it lethal upon dermal or oral exposure. All these characteristics make CYP present a challenge to public health in many countries [18,19] .…”

Section: Discussionmentioning

confidence: 99%

The Potential Protective Role of Hydroxytyrosol against Cypermethrin-induced Histological, Immunohistochemical and Biochemical Changes in Lung of Adult Male Albino Rats

Tharwat

Moawad

2021

Egyptian Journal of Histology

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Introduction: Cypermethrin (CYP) is a synthetic pyrethroid used as a pesticide. It induces toxicity of different organs. Hydroxytyrosol (HT) can protect against oxidant-induced toxicity and promote programmed apoptosis counteracting cellular infiltration. Aim of the Work:The present study aimed to assess the CYP-induced histological, immunohistochemical and biochemical changes in rat lungs and to clarify the protective role of HT. Materials and Methods: Forty adult male albino rats, their wights were (150-200 g), were used. The rats were equally distributed into four groups as follows; control group gavaged by oral route with corn oil (1 ml/kg/day), HT group gavaged by oral route with HT (50 mg/kg/day dissolved in I ml distilled water), CYP-treated group gavaged by oral route with CYP (20 mg/kg/day dissolved in I ml corn oil), and CYP+HT treated group treated orally with CYP and HT (as previous doses) for 14 days. All groups underwent histological lung examination, immunohistochemical, morphometric and biochemical analysis. Results: This study showed that CYP caused a significant rise in MDA with a significant decline of SOD, CAT, and GSH levels. Histological changes revealed extensive cellular infiltration, thickening alveolar septum, increased angiogenesis with areas of hemorrhage, extravasation of blood, and decreased areas of ventilation in lungs of rats treated with CYP. Moreover, ultrastructural observations confirmed previous results. A noticeable improvement of the affected lung tissues was observed with HT treatment in the form of regaining of normal epithelial bronchial lining, re-inflation of alveoli and nearly intact intima of the blood vessels as well as restoration of type II pneumocyte structure. Conclusion: HT was proved to ameliorate the CYP-induced histological, immunohistochemical and biochemical changes in rat lung, without abolishing it. This could be explained by HT's anti-inflammatory and antioxidant properties and scavenging abilities against active free radicals. These findings can be of value for future clinical applications.

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Section: Discussionmentioning

confidence: 99%

The Potential Protective Role of Hydroxytyrosol against Cypermethrin-induced Histological, Immunohistochemical and Biochemical Changes in Lung of Adult Male Albino Rats

Tharwat

Moawad

2021

Egyptian Journal of Histology

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“…This would then result in a decrease in testosterone production. Pyrethroids are also capable of interfering with estrogen signaling, affecting male reproductive organs, and altering the quality of semen (Kilian et al 2007;Sharma et al 2018). Furthermore, Cypermethrin had a toxic effect on the rabbit reproductive system, as evidenced by changes in endocrine hormones as a result of direct impact on testes androgen biosynthesis pathways, or gonadotropin levels changes as a result of Leydig cell damage or direct influence on 3ßhydroxysteroid dehydrogenase (3ß-HSD) enzyme gene expression that converts pregnenolone to progesterone.…”

Section: )mentioning

confidence: 99%

Comparative impact of selenium and Nano-selenium on cypermethrin induced toxicity in experimental rabbits

2023

Egyptian Journal of Animal Health

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T he study's goal is to show comparative effects of selenium and Nanoselenium in reduction of the negative side effects of cypermethrin in male rabbits. Forty rabbits were divided into four groups: normal control (G1), groups (G2, G3, and G4) that were given cypermethrin (1/100 of LD50, equivalent to 24 mg/kg b. wt) three times per week via stomach tube.G3 and G4 received oral treatments with selenium and Nano-selenium at doses of 0.5 mg/kg b.wt. after two hours of cypermethrin for four weeks. The administration of selenium and Nano-selenium (G3&G4) significantly reduced liver function enzymes and significantly increased growth, total protein (TP), albumin, and globulin levels compared to G2 levels, in addition to normalizing the lipid profile. Prominent downregulation of NO and proinflammatory cytokines (IL-6 and TNF-α) levels and upregulation of lysozyme were elicited in Nano-selenium (G4) treatment than selenium (G3). Selenium and Nano-selenium (G3 and G4) increase testosterone and estrogen levels and decrease LH and FSH compared to G2. Nano-selenium administration (G4) could restore hormone levels to normal (G1).As opposed to Nano-selenium, administration of selenium (G3) showed a lower level of cypermethrin residue in the liver, kidney, and muscle. According to those findings, Nano-selenium outperformed selenium in its capacity to reduce cypermethrin adverse effects.

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“…Due to the extremely wide application of pyrethroids, problems such as toxicity to mammals and aquatic organisms can occur [7]. Cypermethrin is one of the most studied pyrethroids [15]. Toxicity can be tested in vivo in fish models to detect toxicity to aquatic animals and in rat/mouse models to detect toxicity to mammals.…”

Section: Pyrethroidsmentioning

confidence: 99%

Severe pulmonary toxicity associated with inhalation of pyrethroid-based domestic insecticides (Bop/Sapolio): a case series and literature review

Vorselaars

Berg

Drent

2021

Current Opinion in Pulmonary Medicine

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Cypermethrin Toxicity: A Review

Cited by 21 publications

References 0 publications

The Potential Protective Role of Hydroxytyrosol against Cypermethrin-induced Histological, Immunohistochemical and Biochemical Changes in Lung of Adult Male Albino Rats

The Potential Protective Role of Hydroxytyrosol against Cypermethrin-induced Histological, Immunohistochemical and Biochemical Changes in Lung of Adult Male Albino Rats

Comparative impact of selenium and Nano-selenium on cypermethrin induced toxicity in experimental rabbits

Severe pulmonary toxicity associated with inhalation of pyrethroid-based domestic insecticides (Bop/Sapolio): a case series and literature review

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