Cyperus rotundus extract inhibits acetylcholinesterase activity from animal and plants as well as inhibits germination and seedling growth in wheat and tomato

Sharma, R. P.; Gupta, Rajendra

doi:10.1016/j.lfs.2007.01.060

Cited by 58 publications

(30 citation statements)

References 14 publications

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“…Its rhizomes have been used in traditional Chinese medicine as estrogenic and anti-inflammatory agents for the treatment of stomachache and bowel disorders, dysmenorrhea, and menstrual disorders. [1] It has recently received much attention due to the broad range of biological activities, such as anti-diabetic activity, [2] acetylcholinesterase inhibitory activity, [3] anti-diarrhoeal activity, [4] protein glycation inhibitory activity, [5] as well as inhibition of nitric oxide and superoxide production. [6] Sesquiterpenes have been considered as its characteristic secondary metabolites and should be responsible for those activities.…”

Section: Introductionmentioning

confidence: 99%

“…[6] Sesquiterpenes have been considered as its characteristic secondary metabolites and should be responsible for those activities. Previous phytochemical investigations have described the presence of sesquiterpenes with diverse skeletons such as patchoulane, rotundane, eudesmane, guaiane, cadinane, and caryophyllene types in C. rotundus L. [7,8] As a part of our research program that involves studying naturally occurring sesquiterpenes, [9,10] two guaiane type sesquiterpenes (1, 2) and four patchoulane type sesquiterpenes (3)(4)(5)(6) were isolated from the rhizomes of C. rotundus L., of which 1 and 3 were new compounds. This paper describes the structural determination and the complete assignments of 1 H and 13 C NMR data of those sesquiterpenes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Complete assignments of ¹H and ¹³C NMR data for two new sesquiterpenes from Cyperus rotundus L.

Zhang

Wan

et al. 2009

Magnetic Reson in Chemistry

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Two new sesquiterpenes, epi-guaidiol A (1) and sugebiol (3), together with four known sesquiterpenes, guaidiol A(2), sugetriol triacetate (4), cyperenoic acid (5), and cyperotundone (6) were isolated from the rhizomes of Cyperus rotundus L. Their structures were identified by MS and NMR experiments, and the complete assignments of (1)H and (13)C NMR data for two new sesquiterpenes were obtained by the aid of two-dimensional (2D) NMR techniques, including HSQC, HMBC, (1)H-(1)HCOSY and nuclear overhauser enhancement spectroscopy(NOESY).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Complete assignments of ¹H and ¹³C NMR data for two new sesquiterpenes from Cyperus rotundus L.

Zhang

Wan

et al. 2009

Magnetic Reson in Chemistry

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“…The rhizome of Cyperus is rich in essential oils that contain pinene, a little cineole, terpenes, and a new alcohol called isociprol. Several chemical components have been isolated from ethanol extract of C. rotundus rhizome and some of these chemicals possess anti-AChE activity [28]. Gingko biloba extract significantly inhibit the AChE activity in the brain.…”

Section: Acetylcholinesterase Inhibitors From Plantsmentioning

confidence: 99%

Acetylcholinesterase inhibition by medicinal plants: A Review

Ranjan

Kumari

2017

Ann.Pl.Sci.

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Acetylcholinesterase (AChE), the predominant cholinesterase in the brain, hydrolyzes ACh to choline and acetate, thereby terminating the effect of this neurotransmitter at cholinergic synapses. Therefore, AChE is the target of cholinesterase inhibitors used for addressing the cholinergic deficit in Alzheimer's disease (AD) patients. Despite decades of research and advances in our understanding of its aetiology and pathogenesis, current pharmacotherapeutic options for AD are still very limited and represent an area of need that is currently unmet. The leading AD therapeutics involves AChE inhibitors, resulting in increased acetylcholine concentrations in the synaptic cleft and enhanced cholinergic transmission. Compounds showing an AChE inhibitory effect are also used for the treatment of senile dementia, myastenia gravis, Parkinson's disease and ataxia. Taking into account that the inhibition of AChE has been one of the most used strategies for treating AD and that existing drugs are effective only against mild to moderate type of disease while presenting considerable side effects, the search for new sources of effective and selective anti acetylcholinesterase agents with fewer side effects is imperative. Various plants and phytochemical substances have demonstrated AChE inhibitory activity and thus could be beneficial in the treatment of neurodegenerative disorders such as AD.

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“…The tuber part of C. rotundus is a commonly used traditional Oriental medicine for treatment of dysmenorrhea and other menstrual irregularities. This herb is also widely used as an analgesic, nerve tonic, nootropic, sedative, anti-spasmodic, anti-malarial, antidiarrheal and a reliever of stomach disorders (13)(14)(15)(16)(17). Previous pharmacological investigations indicated that the extracts and/ or components of C. rotundus rhizomes have marked hypotensive, anti-mutagenic, anti-obese, neuroprotective, antioxidant, anti-inflammatory and anti-pyretic effects (18)(19)(20)(21)(22)(23)(24)(25)(26).…”

Section: Induction Of Apoptosis In Mda-mb-231 Human Breast Carcinoma mentioning

confidence: 99%

Induction of apoptosis in MDA-MB-231 human breast carcinoma cells with an ethanol extract of Cyperus rotundus L. by activating caspases

et al. 2014

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Abstract. Cyperus rotundus L. belongs to the Cyperaceae family and is a well documented traditional medicinal herb. Its rhizome has been reported to possess wide spectrum pharmacological activities including anti-inflammatory and antioxidant activity. However, the cellular and molecular mechanisms of the anticancer activity have not been elucidated. In the present study, we investigated the pro-apoptotic effects of C. rotundu rhizomes in a human breast carcinoma MDA-MB-231 cell model. Treatment of MDA-MB-231 cells with an ethanol extract of C. rotundu rhizomes (EECR) and a methanol extract of C. rotundu rhizomes (MECR), but not a water extract of C. rotundu rhizomes, resulted in potent antiproliferative activity. The activity of the EECR was higher than that of the MECR and was associated with the induction of apoptosis. The induction of apoptosis by the EECR was associated with upregulation of death receptor 4 (DR4), DR5 and pro-apoptotic Bax, as well as downregulation of anti-apoptotic survivin and Bcl-2. EECR treatment also downregulated Bid expression and activated caspase-8 and -9, the respective initiator caspases of the extrinsic and intrinsic apoptotic pathways. The increase in mitochondrial membrane depolarization was correlated with activation of effector caspase-3 and cleavage of poly(ADP-ribose) polymerase, a vital substrate of activated caspase-3. Blockage of caspase activation by pretreatment with a pan-caspase inhibitor consistently inhibited apoptosis and abrogated growth inhibition in EECR-treated MDA-MB-231 cells. Although reactive oxygen species (ROS) increased following treatment with the EECR, inhibiting ROS with a ROS scavenger did not attenuate EECR-induced apoptosis. Furthermore, inhibitors of phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) signaling pathways failed to reverse EECR-induced apoptosis and growth inhibition. These results suggest that the pro-apoptotic activity of the EECR may be regulated by a caspase-dependent cascade through activation of both intrinsic and extrinsic signaling pathways that is not associated with ROS generation or the PI3K/Akt and MAPK pathways.

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Cyperus rotundus extract inhibits acetylcholinesterase activity from animal and plants as well as inhibits germination and seedling growth in wheat and tomato

Cited by 58 publications

References 14 publications

Complete assignments of ¹H and ¹³C NMR data for two new sesquiterpenes from Cyperus rotundus L.

Complete assignments of ¹H and ¹³C NMR data for two new sesquiterpenes from Cyperus rotundus L.

Acetylcholinesterase inhibition by medicinal plants: A Review

Induction of apoptosis in MDA-MB-231 human breast carcinoma cells with an ethanol extract of Cyperus rotundus L. by activating caspases

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Cyperus rotundus extract inhibits acetylcholinesterase activity from animal and plants as well as inhibits germination and seedling growth in wheat and tomato

Cited by 58 publications

References 14 publications

Complete assignments of 1H and 13C NMR data for two new sesquiterpenes from Cyperus rotundus L.

Complete assignments of 1H and 13C NMR data for two new sesquiterpenes from Cyperus rotundus L.

Acetylcholinesterase inhibition by medicinal plants: A Review

Induction of apoptosis in MDA-MB-231 human breast carcinoma cells with an ethanol extract of Cyperus rotundus L. by activating caspases

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Product

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Complete assignments of ¹H and ¹³C NMR data for two new sesquiterpenes from Cyperus rotundus L.

Complete assignments of ¹H and ¹³C NMR data for two new sesquiterpenes from Cyperus rotundus L.