Cystatin C Concentration During the First Three Postnatal Days in Healthy Term Newborns

Abstract

Objective Cystatin C (Cys-C) concentration has not been examined sufficiently among healthy newborn population, particularly in terms of reference values. This study aimed to establish gender-, postnatal age- and birth weight-specific Cys-C concentration for healthy term newborns. Its objective was also to examine if there were any differences between our measured concentration and the reference interval established by the CALIPER study. Methods Serum samples from a total of 90 healthy term newborns were used to determine Cys-C concentration. Cys-C was measured within first three days of birth using particle-enhanced turbidimetric immunoassay (PETIA) on the Architect plus ci8200 analyzer. Results Median concentration of the Cys-C was 2.05 mg/L. There were no statistically significant differences in Cys-C concentration regarding gender (p=0.779), birth weight (p=0.505), postnatal age (p=0.512) or Apgar score (p=0.799). The value of the 2.5th and 97.5th percentile for Cys-C concentrations for girls was 0.93–3.15 mg/L and for boys it was 1.5–3.36 mg/L. Conclusion Cys-C concentration in healthy term newborns does not depend on gender, birth weight, postnatal age, or Apgar score. Our measured concentration range of CyS-C in healthy newborns turned out to be slightly wider than the interval determined in the CALIPER study.

Detecting Neonatal AKI by Serum Cystatin C

“…In a study of 50 term and 58 preterm neonates, Harmoinen et al 17 reported a reference interval of 1.34-2.57 mg/L and 1.36-2.23 mg/L, respectively, for the preterm and the term neonates. In a study of 90 term neonates, Mikulic et al 18 reported a reference interval of 0.93-3.15 mg/L and 1.5-3.36 mg/L, respectively, for girls and boys. Tong et al 19 investigated gestational and age-specific Cys-C reference intervals in 1044 neonates, and the reference intervals were generally within the range of 1.3-2.3 mg/L for the neonates whose gestational age was older than 28 weeks.…”

“…16 Neonatal serum Cys-C originates almost exclusively in the neonate, making it a promising alternative to SCr for evaluating renal function in neonates. Currently, the reference interval of serum Cys-C in neonates have only been reported in a few small studies, [17][18][19] and the reference change value (RCV) of serum Cys-C in neonates have not been investigated.…”