Cystatin C in Evaluating Renal Function in Ureteral Calculi Hydronephrosis in Adults

Abstract

Background: Serum cystatin C (CysC) is still becoming used as a marker of renal function but is far from being commonly used worldwide. The purpose of this study was to characterize the ureteral calculi patients with hydronephrosis-caused CysC changes in renal function. Methods: To better reflect the changes of renal function, we constructed models of ureteral obstruction in rats to mimic the hydronephrosis caused by human ureteral calculi. Moreover, our study included 200 patients diagnosed with ureteral calculi in our hospital between June 2017 and 2018. We compared the estimated glomerular filtration rate using different equations based on CysC and/or serum creatinine (SCr). Results: We found that the expression of CysC and SCr increased with the prolonged obstruction time by enzyme linked immunosorbent assay. Moreover, quantitative real-time polymerase chain reaction, Western blot and immunohistochemistry further demonstrated that the expression of CysC increases with the degree of hydronephrosis. Among 200 patients with ureteral calculi, 40 (20.0%) had no hydronephrosis, 110 (55.0%) had mild hydronephrosis, 32 (16.0%) had moderate hydronephrosis and 18 (9.0%) had severe hydronephrosis. As the degree of hydronephrosis increased, the expression of neutrophil percentage, CysC, blood urea nitrogen, SCr and serum uric acid also increased. Multivariate analyses demonstrated that only CysC was an independent risk factor for hydronephrosis (p = 0.003). In addition, CysC and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) CysC equation showed the highest veracity in renal function estimation of patients with hydronephrosis caused by ureteral calculus. Conclusion: For patients with hydronephrosis caused by ureteral calculi, CysC better reflects the changes in renal function, and the CKD-EPI CysC equation has the highest accuracy.

High levels of cathepsin S and cystatin C in patients with fibromyalgia syndrome

“…24 In particular, the association of CysC with renal, cardiovascular and nervous system diseases is well known. [25][26][27] There are few studies evaluating the relationship between CysC and pain in the literature.…”

“…It has been claimed that serum CysC level can be used as a biomarker for some diseases because it is not affected by factors such as diet, age and gender 24 . In particular, the association of CysC with renal, cardiovascular and nervous system diseases is well known 25‐27 . There are few studies evaluating the relationship between CysC and pain in the literature.…”

Acute Kidney Injury Caused by Obstructive Nephropathy

“…Estimating and measuring GFR in patients with AKI is not suggested [65]. ough there are considerable limitations, there have been attempts made to evaluate cystatin C in patients with ON, which demonstrates a better performance than creatinine, as its increase is a better indicator of the severity of hydronephrosis [66].…”

<p>Impact of Nutritional Indices on the Survival Outcomes of Patients with Colorectal Cancer</p>

“…MedCalc (MedCalc Software Ltd, Shen Zhen, China) version 15.2.0 software was used to calculate the optimal cut-off value of the PNI, PAB and AGR. 13 The baseline characteristics between groups were compared using independent sample t-tests and chi-square tests as appropriate. Overall survival (OS) curves were drawn by the Kaplan-Meier method and evaluated using the log-rank test.…”