Cystic endometrial hyperplasia- pyometra complex in the bitch: should the two entities be disconnected?

Bosschere, H. De; Ducatelle, Richard; Vermeirsch, H.; Broeck, Wim Van Den; Coryn, M.

doi:10.1016/s0093-691x(01)00498-8

Cited by 125 publications

(157 citation statements)

References 11 publications

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“…The endometrium/ myometrium ratio is high in the proestrus, due to edema and hyperplasia of the endometrium, this ratio decreases strongly in the estrus and then during diestrus a slight increase is observed (De Bosschere et al 2001).…”

Section: Introductionmentioning

confidence: 96%

“…During the estrous cycle, the endometrium of the bitch undergoes morphological and biochemical alterations that are associated with proliferation, apoptosis and cellular differentiation (Cruz 2011), these alterations are under the influence of P4 and E2 (De Bosschere et al 2001). The endometrium/ myometrium ratio is high in the proestrus, due to edema and hyperplasia of the endometrium, this ratio decreases strongly in the estrus and then during diestrus a slight increase is observed (De Bosschere et al 2001).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Gossler

Santos

Azevedo

et al. 2017

An. Acad. Bras. Ciênc.

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This study aimed to determine the histological features of the endometrium of bitches, as well as the cell proliferation at specific moments of diestrus, 10, 20, 30, 40, 50 and 60 days post ovulation, correlating the endometrial thickness with the uterine cell proliferation and the metabolic state (weight, blood glucose and plasma cholesterol) of the animals. Therefore, the right and left uterine horns of 26 clinically healthy bitches submitted to ovariohysterectomy were histologically analyzed 10, 20, 30, 40, 50 and 60 days post ovulation. The hematoxylin-eosin and AgNOR staining techniques were performed. All parameters were evaluated by ANOVA and post-hoc Tukey test (p<0.05). The correlation between endometrial thickness and uterine cell proliferation, weight, blood glucose and plasma cholesterol of animals was observed using the Pearson method (p<0.05). In the present study, it is concluded that endometrial thickness does not differ at any of the moments analyzed in diestrus. The endometrial thickness is not influenced by hormones, weight, blood glucose or serum cholesterol of bitches in this phase of the estrous cycle. However, there is greater cell proliferation in the endometrium at day 40 compared to day 60 post ovulation under the influence of the endocrine profile.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Gossler

Santos

Azevedo

et al. 2017

An. Acad. Bras. Ciênc.

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“…A subclinical infection of the uterus or endometrium caused by foreign bodies at the end of estrus or during the first half of diestrus provides the stimulus to begin the process of excessive endometrial hypertrophy and hyperplasia. The secretions that result from glandular proliferation in the endometrium may initiate the development of pyometra or mucometra if the causative agent is or is not a bacterium, respectively (De Bosschere et al, 2001). The patient in this case was an elderly female dog that had cystic endometrial hyperplasia on both uterine horns.…”

Section: Discussionmentioning

confidence: 97%

“…The progressive degenerative process in the development of cystic endometrial hyperplasia, which is due to fibrosis and glandular distension, has been proposed as an initial lesion of pyometra in elderly female dogs, which is mediated by progesterone and exacerbated by estrogen (De Bosschere et al, 2001). Nomura and Nishida (1998) demonstrated that the paradigm of progesterone resulting in cystic endometrial hyperplasia, which results in pyometra, may not always be correct; instead, bacteria may be the initial causative agent of pyometra.…”

Section: Discussionmentioning

confidence: 99%

Mummified papyraceous fetuses in the abdominal cavity of an elderly female dog with pyometra

Voorwald¹,

Tiosso²,

Cardilli³

et al. 2012

Arq. Bras. Med. Vet. Zootec.

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This paper reports on a rare case of fetal papyraceous mummification after asymptomatic uterine rupture in an elderly female dog with pyometra. The patient had a history of mating six months before the examination but no apparent signs of gestation or parturition. Exploratory laparotomy was used to identify a rupture of the left uterine horn and the presence of cystic endometrial hyperplasia and pyometra. Two mummified papyraceous fetuses were observed in the abdominal cavity and had adhered to the spleen, pancreas, intestine and omentum. Ovariehysterectomy and corrective surgery were performed. The patient had remained healthy after uterine rupture until a new estrous cycle and the development of pyometra. Bitches that are 10 years old or more are predisposed to implantation failure, pregnancy or parturition problems and they should not be breed to avoid complications.Keywords: bitch, uterine rupture, fetal mummification, papyraceous RESUMO Relatou-se um caso raro de mumificação fetal papirácea após ruptura uterina assintomática em uma cadela idosa, acometida por piometra. A paciente apresentava histórico de cópula seis meses antes do

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“…In addition to the antibody-mediated ovarian response, a small number of VAP1-immunized females demonstrated uterine changes consistent with endometrial cystic hyperplasia (De Bosschere et al 2001), raising the possibility that a uterine immune response may contribute to this condition. The presence of macrophage clusters within enlarged endometrial glands suggests a cell-mediated reaction, possibly in response to the presence of a failed conceptus.…”

Section: Discussionmentioning

confidence: 99%

Vesicle-associated protein 1: a novel ovarian immunocontraceptive target in the common brushtail possum, Trichosurus vulpecula

Nation

Cui²,

Selwood

2008

Reproduction

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Ovarian-based immunological research is currently restricted to proteins of the zona pellucida. This study examined the immunocontraceptive potential of a novel vesicle-associated protein, VAP1, previously isolated from the vesicle-rich hemisphere of the brushtail possum oocyte. Seven female possums were immunized against recombinant glutathione S-transferase-VAP1 fusion protein. Control animals (n=3) received antigen-free vaccinations. Following immunization, regular blood sampling determined the level and duration of immune response. Animals were monitored daily, pre- and post-immunization, to determine estrous cycling activity and the percentage of reproductive cycles yielding viable young. The reproductive tracts and somatic organs of VAP1-immunized (n=7), control-immunized (n=3) and non-immunized (n=5) animals were collected and examined by histology and transmission electron microscopy. VAP1 immunization caused a strong and sustained immune response. Elevated levels of VAP1 antibody binding were detected in sera following initial injections, and immune titers rose as boosters were administered. Immunization had no adverse effect upon animal behavior or body condition. Immunized females demonstrated no major change in annual estrous cycling activity; however, the percentage of reproductive cycles resulting in pouch young decreased significantly (P<0.05) by 40%. Histological and ultrastructural analyses revealed an abundance of lipid-like degradation bodies within the ooplasm of developing oocytes and the cytoplasm of failing uterine zygotes. Active macrophage invasion of enlarged endometrial glands was observed in the uteri of two females. Reproductive tract changes are discussed in relation to observed fertility decline. The results of this study indicate that VAP1 has exciting potential as an immunocontraceptive target for possum control in New Zealand.

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Cystic endometrial hyperplasia- pyometra complex in the bitch: should the two entities be disconnected?

Cited by 125 publications

References 11 publications

Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Mummified papyraceous fetuses in the abdominal cavity of an elderly female dog with pyometra

Vesicle-associated protein 1: a novel ovarian immunocontraceptive target in the common brushtail possum, Trichosurus vulpecula

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