Cystic renal cell carcinoma: Radiological features and clinico-pathological correlation

Ooi, G. C.; Sagar, G.; Lynch, D; Arkell, D. G.; Ryan, Peter

doi:10.1016/s0009-9260(96)80007-9

Cited by 31 publications

(12 citation statements)

References 29 publications

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“…Since these early theories, it is apparent that there are several permutations on the renal cysts and RCC theme that merit separation (33)(34)(35)(36)(37)(38)(39)(40). These are noted in Table 3 with comments on their significance.…”

Section: Resultsmentioning

confidence: 99%

Renal Cystic Diseases and Renal Neoplasms

Bonsib¹

2009

Clinical Journal of the American Society of Nephrology

105

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The past two decades have witnessed recognition of several new types of renal cell carcinoma, each with distinct cytogenetic abnormalities. Included are several genetic and acquired cystic kidney diseases associated with development of renal cell carcinoma, the topic of this review. The risk in patients with autosomal dominant polycystic kidney disease is not accurately known but may be slightly increased. The risk for patients with von Hippel-Lindau disease is substantial, and death from renal cancer is common. For patients with tuberous sclerosis complex, the challenge is recognition of the occasional malignancy arising in a field of many benign tumors. Patients with end-stage kidney disease and acquired cystic kidney disease may develop a variety of renal cell carcinoma types. Progress in understanding the molecular basis of renal cyst formation and neoplastic disease has fostered development of targeted therapies that now hold promise for a group of neoplasms whose cure was traditionally dependent on surgical approaches.

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Section: Resultsmentioning

confidence: 99%

Renal Cystic Diseases and Renal Neoplasms

Bonsib¹

2009

Clinical Journal of the American Society of Nephrology

105

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“…Prior to surgical exploration and pathological evaluation, it is diYcult to identify MCRCC with conWdence. The diVerential diagnosis of a complex, enhancing, cystic renal abnormality includes a pseudocyst stemming from hemorrhage and necrosis of RCC, cystic necrosis of Wilms' tumor, hemorrhage and infection of a simple cyst, renal impairment caused by tuberous sclerosis, as well as multilocular cystic nephroma, renal abscess, and xanthogranulomatous pyelonephritis (Koga et al 2000;Ooi et al 1996;Bielsa et al 1998). In our series, most cases of MCRCC (90.3%) at our institute were found when they were examined for reasons other than the typical symptoms of renal carcinoma such as hematuria.…”

Section: Discussionmentioning

confidence: 99%

Multilocular cystic renal cell carcinoma: an experience of clinical management for 31 cases

Gong

Zhang

et al. 2007

J Cancer Res Clin Oncol

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In order to increase our knowledge and understanding about multilocular cystic renal cell carcinoma (MCRCC), including diagnosis, surgical management, pathologic and prognostic characteristics, clinical data of patients who suffered with MCRCC were reviewed retrospectively. From 1998 to 2005, among 770 patients diagnosed with renal cell carcinoma (RCC) at our institute, 31 cases (4.0%) were identified as MCRCC. The average age of patients suffered with RCC and MCRCC was 58.1 +/- 3.6 and 45.9 +/- 2.7, respectively (P < 0.01), whereas the gender ratio of male to female in RCC and MCRCC is 2.12:1 and 2.88:1(P < 0.01). Surprisingly, 28 of those 31 renal masses (90.3%) were first discovered on the radiographic image, and the size of tumors in maximum diameter ranged from 1.7 to 11.0 cm (mean 4.1 +/- 2.2 cm). All those patients were treated with open nephrectomy, including 21 radical and 10 partial. The stages of tumor were classified as pT1N0M0, pT2N0M0, and pT3bN0M0 following the 1997 criteria of tumor-node-metastasis (TNM) classification in the number of 27(87.1%), 3(9.7%) and 1(3.2%), respectively. By contrast, according to the tumor nuclear grading system, those tumors were classified as Grades 1 and 2 in 13 (42%) and 18 patients (58%), respectively. Only 29 cases from those patients have been followedup for a period of 9 to 81 months so far (mean 32.6 +/- 11), while no tumor recurrence occurred except for 1 case who died of causes other than MCRCC. In general, MCRCC is a frequent subtype of RCC in the clinic. A nephron-sparing procedure should be considered in the preoperative plan when a complex multicystic renal mass with enhanced density is observed.

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“…Bielsa et al (10) noted that because cystic RCC was usually identified at earlier stages, had a slower growth rate, and was therefore associated with a better prognosis and longer survival than conventional RCC, a conservative surgical approach should be the treatment of choice whenever technically feasible. Ooi et al (11) reported the high percentage of stage-1 disease (72.7%, 8/11) in cystic RCCs.…”

Section: Discussionmentioning

confidence: 99%

CT and US Findings of Multilocular Cystic Renal Cell Carcinoma

Kim

Kim²,

Lee

2000

Korean J Radiol

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ObjectiveMultilocular cystic renal cell carcinoma (MCRCC) is a recently described variety of renal cell carcinoma with characteristic pathologic and clinical features. The purpose of this study was to analyze the imaging findings of MCRCCs.Materials and MethodsTen adult patients with pathologically proven unilateral MCRCC who underwent renal US and CT were included in this study. The radiologic findings were retrospectively evaluated for cystic content, wall, septum, nodularity, calcification and solid portion by three radiologists who established a consensus. Imaging and postnephrectomy pathologic findings were compared.ResultsAll patients were adults (six males and four females) and their ages ranged from 33 to 68 years (mean, 46). On US and CT images, all tumors appeared as well-defined multilocular cystic masses composed of serous or complicated fluid. In all patients, unenhanced CT scans revealed hypodense cystic portions, and in four tumors, due to the presence of hemorrhage or gelatinous fluid, some hyperdense areas were also noted. In no tumor was an expansile solid nodule seen in the thin septa, and in only one was there dystrophic calcification in a septum. Small areas of solid portion constituting less than 10% of the entire lesion were found in six of the ten tumors, and these areas were slightly enhanced on enhanced CT scans. In all patients, imaging and pathologic findings correlated closely.ConclusionOn US and CT images, MCRCC appeared as a well-defined multilocular cystic mass with serous, proteinaceous or hemorrhagic fluid, with no expansile solid nodules in the thin septa, and sometimes with small slightly enhanced solid areas. Where radiologic examinations demonstrate a cystic renal mass of this kind in adult males, MCRCC should be included in the differential diagnosis.

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Cystic renal cell carcinoma: Radiological features and clinico-pathological correlation

Cited by 31 publications

References 29 publications

Renal Cystic Diseases and Renal Neoplasms

Renal Cystic Diseases and Renal Neoplasms

Multilocular cystic renal cell carcinoma: an experience of clinical management for 31 cases

CT and US Findings of Multilocular Cystic Renal Cell Carcinoma

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