Cystoid macular edema associated with PVP coating of an intraocular lens

Implantation of a poly(methyl methacrylate) (PMMA) intraocular lens (IOL) after cataract surgery is associated with breakdown of the blood-ocular barrier and a foreign body inflammatory response. Although the material is biocompatible, it is not inert. The history of PMMA IOL implantation has reflected mechanical, chemical, and immunological interactions between the IOL and ocular tissues. The common link in these events is instability of the blood-ocular barrier. In this lecture, I discuss the nature of these interactions and present evidence that currently investigated methods of surface modification and capsular bag IOL implantation are effective in stabilizing the blood-ocular barrier.

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Surface modification: On the path toward greater biocompatibility

Obstbaum¹

1989

Journal of Cataract and Refractive Surgery

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Cystoid macular edema associated with PVP coating of an intraocular lens

Cited by 5 publications

References 3 publications

Prophylaxis and therapy of aphakic cystoid macular edema

Prophylaxis and therapy of aphakic cystoid macular edema

The Binkhorst Medal Lecture Biologic relationship between poly(methyl methacrylate) intraocular lenses and uveal tissue

Surface modification: On the path toward greater biocompatibility

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