Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women

Shin, Aesun; Kang, Daehee; Choi, Ji-Yeob; Lee, Eunil; Park, Sue Kyung; Noh, Dong‐Young; Ahn, Sei‐Hyun; Yoo, Keun-Young

doi:10.1038/emm.2007.40

Cited by 42 publications

(30 citation statements)

References 19 publications

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“…Examining genotype frequencies in controls, significant deviation from HWE was detected in four studies, i.e., the Caucasian part of the study by Bailey et al [41], the Caucasian part of the study by Taioli et al [29], the study by Chacko et al [51] and Shin et al [63]. After the exclusion of the four studies significantly departing from HWE the results remained practically unchanged.…”

Section: T3801c Polymorphismmentioning

confidence: 87%

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Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis

Sergentanis

Economopoulos

2009

Breast Cancer Res Treat

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Cytochrome P450s are enzymes which catalyze Phase-I metabolism reactions; cytochrome P450 1A1 (CYP1A1) is a member of the CYP1 family and participates in the metabolism of a vast number of xenobiotics, as well as endogenous substrates. Four single nucleotide polymorphisms in CYP1A1 have been studied concerning their potential implication in terms of breast cancer risk: T3801C, T3205C, A2455G (Ile462Val), and C2453A (Thr461Asp); controversy exists regarding their role. This meta-analysis aims to examine whether the four aforementioned polymorphisms are associated with breast cancer risk. Separate analyses were performed on Caucasian, Chinese, and African populations, as well as on premenopausal and postmenopausal women. Eligible articles were identified by a search of MEDLINE bibliographical database for the period up to October 2009. Concerning T3801C, 32 studies were eligible (11,909 cases and 16,179 controls), 29 studies (12,257 cases and 20,379 controls) were eligible for A2455G, 11 studies (7,189 cases and 8,491 controls) were eligible for C2453A, and eight studies were eligible for T3205C (1,378 cases and 1,642 controls). Pooled odds ratios (OR) were appropriately derived from fixed-or random-effect models. Sensitivity analysis excluding studies whose genotype frequencies in controls significantly deviated from Hardy-Weinberg equilibrium was performed. Homozygous subjects of Caucasian origin carrying the A2455G G allele exhibited elevated breast cancer risk (pooled OR = 2.185, 95% CI 1.253-3.808, fixed effects), whereas heterozygous carriers did not (pooled OR = 1.062, 95% CI 0.852-1.323, random effects). A2455G polymorphism status was not associated with breast cancer risk in Chinese subjects or specifically in premenopausal/postmenopausal women. T3801C, T3205C, and C2453A status were not associated with breast cancer risk at any analysis. In conclusion, this meta-analysis points to the A2455G G allele as a risk factor for breast cancer among Caucasian subjects. On the contrary, T3801C, T3205C, and C2453A status does not seem capable of modifying breast cancer risk.

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Section: T3801c Polymorphismmentioning

confidence: 87%

“…Concerning T3801C polymorphism, 32 studies were eligible (11,909 [28,31,33,50,54,62,63,66]; and three studies on African subjects (356 cases and 459 controls) [29,34,41].…”

Section: Eligible Studiesmentioning

confidence: 99%

Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis

Sergentanis

Economopoulos

2009

Breast Cancer Res Treat

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“…Results of association studies for this SNP are similar to other two SNPs and controversial as well. Associations of this polymorphism was proved in African-American population (Taioli et al, 1995), and also in Korean and Chinese populations (Shen et al, 2006;Shin et al, 2007), but Kiruthiga et al (2011) found no specific association of this polymorphism with breast cancer in Indian women.…”

Section: Discussionmentioning

confidence: 99%

Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer

Farzaneh¹,

Noghabaei²,

Barouti³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Breast cancer (BC) is the most common cancer and the second cause of mortality in women all around the world. It is caused by several factors including genetic determinants, so that both genetic susceptibility factors and environmental factors are involved in the etiology. Significance of genes functioning in steroid hormone synthesis and metabolism are well established in breast cancer susceptibility. In this study, 134 women with BC and 135 normal controls were analyzed for their genotypes for the polymorphisms, rs743572, rs10046 and rs4646903, resided in CYP17, CYP19 and CYP1A1 genes, respectively. Significant differences in distributions of allele and genotype frequencies were found for the rs10046 polymorphism in CYP19 (p-value=0.01, OR (CI 95%) =1.59 (1.1-2.3), p-value=0.04, OR (CI 95%) =1.7 (1.1-2.5) respectively). For rs743,572 and rs 4646903 polymorphisms, no significant associations were observed. A significant association was observed between the rs10046 polymorphism of the CYP19gene and breast cancer in Iranian patients. Due to inconsistent previous results, more studies in different populations with larger sample sizes are indicated.

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“…Results of investigations performed in different populations showed controversial results. For example, it was shown that the genotype of clinical significance for Chinese women is CC [10], whereas for Korean women T allele was shown to be a risk associated [11] and for the women of North America [12] the correlations of polymorphism in this site with BC were not evaluated.…”

Section: Resultsmentioning

confidence: 99%

Associations of Polymorphisms of the CYP1A1 and CYP1B1 Cytochrome P450 Genes with Breast Cancer in Kazakhstan

Balmukhanov¹,

Khanseitova²,

Nigmatova³

et al. 2013

ABCR

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Associations of polymorphisms in rs4646903 site of CYP1A1 and rs1056836 site of CYP1B1 genes with the breast cancer (BC) were studied in two main ethnic groups of Kazakhstan Republic (Kazakhs and Russians). Total number of BC patients was 181, controls-397. The statistically significant differences were revealed in allele frequencies (χ 2 = 5.93, р = 0.004) and in genotypes distribution (χ 2 = 8.71, р = 0.015) in rs4646903 site of CYP1A1 gene in Kazakh but not in Russian group. The study of CYP1В1 rs1056836 site demonstrated differences in genotype distributions (χ 2 = 7.48, р = 0.023) between BC patients and controls in Russian but not in Kazakh ethnic group.

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Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women

Cited by 42 publications

References 19 publications

Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis

Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis

Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer

Associations of Polymorphisms of the <i>CYP</i>1<i>A</i>1 and <i>CYP</i>1<i>B</i>1 Cytochrome P450 Genes with Breast Cancer in Kazakhstan

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Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women

Cited by 42 publications

References 19 publications

Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis

Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis

Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer

Associations of Polymorphisms of the &lt;i&gt;CYP&lt;/i&gt;1&lt;i&gt;A&lt;/i&gt;1 and &lt;i&gt;CYP&lt;/i&gt;1&lt;i&gt;B&lt;/i&gt;1 Cytochrome P450 Genes with Breast Cancer in Kazakhstan

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Associations of Polymorphisms of the <i>CYP</i>1<i>A</i>1 and <i>CYP</i>1<i>B</i>1 Cytochrome P450 Genes with Breast Cancer in Kazakhstan