Cytochrome P450 (CYP) Progress in Biocatalysis for Synthetic Organic Chemistry

Moody, Thomas S.; Taylor, Steve

doi:10.1002/9781118697856.ch02

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2023

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“…Several excellent reviews have been published on industrial biocatalysis covering various aspects of enzymatic transformations for drug development. ,,− As such, this perspective does not aim to be comprehensive but rather highlight the current state-of-the-art of preparative enzymatic synthesis in an industrial setting. Therefore, the use of biocatalysis for small-scale pharmaceutical metabolite synthesis, lead diversification, ,,, bioconjugation, and selective protein modification − will not be focused upon in this article.…”

Section: Introductionmentioning

confidence: 99%

The Evolving Nature of Biocatalysis in Pharmaceutical Research and Development

France

Lewis

Martínez

2023

JACS Au

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Biocatalysis is a highly valued enabling technology for pharmaceutical research and development as it can unlock synthetic routes to complex chiral motifs with unparalleled selectivity and efficiency. This perspective aims to review recent advances in the pharmaceutical implementation of biocatalysis across early and late-stage development with a focus on the implementation of processes for preparative-scale syntheses.

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