Cytochrome P4501A induction in brown trout exposed to small streams of an urbanised area: results of a five-year-study

Behrens, Anja; Segner, Helmut

doi:10.1016/j.envpol.2005.01.010

Cited by 35 publications

(18 citation statements)

References 54 publications

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“…In the present study, the fi ndings of the EROD measurements point to a generally low or even non-existing exposure of brown trout from the four rivers to AhR ligands. According to the available literature, hepatic EROD activities of non-exposed (control) brown trout are in the range of 30 to 50 pmol/mg/ min (Whyte et al, 2000;Behrens and Segner, 2005). For the present study we therefore take EROD values of less than 50 pmol/mg/min to represent non-contaminated conditions, while EROD values higher than 50 pmol/mg/ (Hartmann et al, 2006) what may contribute to the elevated EROD activities at these sites.…”

Section: Discussionmentioning

confidence: 99%

“…Establishing cause-effect relationships in fi eld situations can be complicated even for less integrative but more agent-specifi c biological indices such as EROD activity. For instance, for brown trout from two moderately polluted small streams in Southern Germany, Behrens and Segner (2005) found no correlation between hepatic EROD activity and exposure to the classical EROD inducers, PHAHs and PAHs, but the best chemical predictor of EROD activity was copper. Similarly, Adams et al (1999) reported that the EROD response of fi sh correlated better to environmental concentrations of metals than to PHAH levels.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of fish health status in four Swiss rivers showing a decline of brown trout catches

et al. 2007

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Abstract.A pronounced decline in catch of brown trout (Salmo trutta L.) over the last 10-20 years has been reported for many rivers in Switzerland. Impaired health status of the fi shes has been suggested as one possible cause of the decline. The present study investigated the health status of juvenile brown trout from four Swiss rivers which experienced reductions of brown trout catches during the last two decades: Emme, Liechtensteiner Binnenkanal (LBK), Necker and Venoge. A gradient approach was applied, studying at each river a headwater (HW), midstream (D1) and downstream site (D2). Fish health was assessed by the following indices: hepatic 7-ethoxyresorufi n-O-deethylase (EROD) activity, organ (liver, kidney) histopathology, and gross biometric indices (condition factor, hepatosomatic index). Hepatic EROD activities were generally low without showing signifi cant within-or between-stream differences. Histopathological alterations of the liver displayed a moderate downstream increase in the Emme, LBK and Necker, but not in the Venoge. Between-stream differences of liver pathology were small. Kidney histopathology was not different between upstream and downstream sites, except for Emme and Venoge, where fi shes at the downstream sites were infected with the parasite Tetracapsuloides bryosalmonae, the cause of the proliferative kidney disease (PKD). The fi ndings from this study point to an association of within-stream gradients in water quality, PKD prevalence, fi sh health and brown trout biomass, whereas between-stream differences of actual fi sh health status refl ecting the different levels of catch declines observed in the four rivers during the last two decades are not evident.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessment of fish health status in four Swiss rivers showing a decline of brown trout catches

et al. 2007

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“…Moreover, many alternative biotests making use of organisms belonging to various taxonomic groups and trophic levels proved to be useful tools in detecting toxicity risks posed by sediment-bound contaminants (Ingersoll et al 1995(Ingersoll et al , 1997Chapman et al 2002). In addition to biotests, molecular and cellular biomarker responses have been successfully applied to evaluate the relevance of risks posed by complex contaminant mixtures well before implications would evolve at population and community levels (Cajaraville et al 2000;Behrens and Segner 2005). Within biomarker-based assessment schemes, analysis of biomarker responses in molluscs have been extensively used to evaluate site impact in freshwater and marine ecosystems both by active monitoring with transplanted mussels (Quinn et al 2004;Pampanin et al 2005;Guerlet et al 2007;Lekube et al 2014) and in laboratory tests (Eertman et al 1995;Binelli et al 2010;Sundt et al 2011).…”

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confidence: 99%

Evaluation of Multixenobiotic Resistance in Dreissenid Mussels as a Screening Tool for Toxicity in Freshwater Sediments

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Imre²,

Kiss³

et al. 2015

Arch Environ Contam Toxicol

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“…Biochemical markers have been widely used to evaluate the level of contamination of water environment by organochlorine pollutants (Van der Weiden et al 1993;Al-Arabi et al 2005;Behrens and Segner 2005). Increased levels of organic pollutants result in an increase in values of corresponding biochemical markers.…”

Section: Discussionmentioning

confidence: 99%

Organic Pollutant Contamination of the River Tichá Orlice as Assessed by Biochemical Markers

et al. 2008

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Havelková M., Z. Svobodová, J. Kolářová, J. Krijt, D. Némethová, J. Jarkovský, R. Pospíšil: Organic Pollutant Contamination of the River Tichá Orlice as Assessed by Biochemical Markers. Acta Vet. Brno 2008, 77: 133-141. This study used biochemical markers to assess contamination at two contaminated sites (Králíky and Lichkov) and one control site (Červená Voda) on the River Tichá Orlice, a left-side tributary of the River Elbe. The brown trout (Salmo trutta fario) was selected as an indicator species. Enzymes of the first stage of xenobiotic conversion, namely cytochrome P450 (CYP 450) and ethoxyresorufin-O-deethylase (EROD) in the liver were selected as biochemical markers. Blood plasma vitellogenin concentrations were used to evaluate xenoestrogenic effects of contamination. Results were compared with the most important inductors of these markers, i.e. with organic pollutants (PCB, HCH, HCB, OCS and DDT and their metabolites in fish muscle and with PAH concentrations in bottom sediments). The highest contamination with organic pollutants was at Králíky, and this was reflected in increased cytochrome P450, EROD activity and vitellogenin concentrations. Significant differences were demonstrated in EROD activity and vitellogenin concentrations between Králíky and Červená Voda (P < 0.001). At the most contaminated site (Králíky), a significant negative correlation (r s = -0.964) between EROD activity and vitellogenin concentrations was demonstrated. This relationship was discussed from the point of view of a possible induction or inhibition of the assessed biomarkers at persistently highly contaminated sites. Cytochrome P450, EROD, vitellogenin, Salmo trutta fario, PCB, river contaminationThe River Tichá Orlice (Czech Republic) is a tributary of the River Elbe. The River Tichá Orlice is 107.5 km long and its basin covers 755.4 km 2 . Broodstock of brown trout (Salmo trutta fario) and European grayling (Thymallus thymallus) from the upper reaches of the river and its tributary, the Kralický brook, have been used for artificial reproduction. Fish reproductive problems were detected for the first time in the early 1990s, including low effectiveness of spawning. The results of reproduction were not satisfactory and high losses of spawners were noticed. Monitoring the River Tichá Orlice and its tributary Kralický Brook has been proceeding since 1989. The presence of organic pollutants (PCB; DDT and its metabolites, HCB and HCH) and heavy metals in brown trout muscle have been investigated (Kredl et al. 1989;Svobodová et al. 2004;Kolářová et al. 2005). The Kralický brook has been an important source of organic pollutants (Kolářová et al. 2005) and heavy metals (mercury and copper) released by "Tesla Králíky" which manufactures electronics and is located on the Kralický brook (Svobodová et al. 2004).

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Cytochrome P4501A induction in brown trout exposed to small streams of an urbanised area: results of a five-year-study

Cited by 35 publications

References 54 publications

Assessment of fish health status in four Swiss rivers showing a decline of brown trout catches

Assessment of fish health status in four Swiss rivers showing a decline of brown trout catches

Evaluation of Multixenobiotic Resistance in Dreissenid Mussels as a Screening Tool for Toxicity in Freshwater Sediments

Organic Pollutant Contamination of the River Tichá Orlice as Assessed by Biochemical Markers

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