2011
DOI: 10.1016/j.bcp.2011.03.025
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Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation

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Cited by 31 publications
(26 citation statements)
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“…Interleukin 1 beta (IL-1β) protein levels or mRNA expression were determined in 16 studies [46, 8, 9, 21, 22, 30, 32, 35, 37, 3943], at 24 different time points after challenge. At 13 time points microglial activation was present in combination with increased IL-1β protein levels or mRNA expression patterns, from 4 h to 1 week after LPS challenge ( n = 7), from 1 and 56 days after E. coli challenge ( n = 2), and from 4 h to 3 weeks after CFA challenge ( n = 4).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Interleukin 1 beta (IL-1β) protein levels or mRNA expression were determined in 16 studies [46, 8, 9, 21, 22, 30, 32, 35, 37, 3943], at 24 different time points after challenge. At 13 time points microglial activation was present in combination with increased IL-1β protein levels or mRNA expression patterns, from 4 h to 1 week after LPS challenge ( n = 7), from 1 and 56 days after E. coli challenge ( n = 2), and from 4 h to 3 weeks after CFA challenge ( n = 4).…”
Section: Resultsmentioning
confidence: 99%
“…At four time points, microglia were activated but brain IL-10 levels were similar to controls: 1 day after LPS ( n = 1), 1 and 3 days after E. coli ( n = 2), and 2 weeks after CFA challenge ( n = 1). One study showed microglial activation after LPS challenge but decreased levels of IL-10 in the brain [8]. …”
Section: Resultsmentioning
confidence: 99%
“…CYP4As and CYP4Fs are known to inactivate proinflammatory leukotriene B4, which is one of the AA metabolites synthesized by 5-lipoxygenase and a principle mediator of the inflammatory response, initiating and amplifying the generation of cytokines and chemokines by metabolizing to 20-hydroxyl leukotriene B4 (Kalsotra and Strobel, 2006;Hsu et al, 2007;Crooks and Stockley, 1998). Sehgal et al (2011) reported that inhibition and induction of Cyp4Fs enhances and attenuates the inflammatory response triggered by lipopolysaccharide. Our data show that the reduction of microglial activation on the ipsilateral side was observed just after the peak time of [ 11 C]TROA binding.…”
Section: Discussionmentioning
confidence: 99%
“…CYP-dependent ω-hydroxylation and inactivation of LTB 4 is induced by retinoids in skin cells and might contribute to the beneficial effects of retinoids in the treatment of inflammatory skin diseases (Du, Yin, Morrow, Strobel, & Keeney, 2009;Kalsotra et al, 2008). CYP4F enzymes are also expressed in neurons and glia, and LTB 4 hydroxylase activity limits neuroinflammation in mouse models (Sehgal et al, 2011). Genetic association studies link variants of the CYP4F3 and CYP4F2 genes with celiac disease and Crohn's disease, inflammatory disorders of the gastrointestinal tract (Costea et al, 2010;Curley, Monsuur, Wapenaar, Rioux, & Wijmenga, 2006).…”
Section: Ltb 4 Inactivationmentioning
confidence: 98%