Cytogenetic abnormalities in a squamous cell carcinoma of the penis

Xiao, Sheng; Feng, Xing; Shi, Yanhua; Liu, Quan-Zhang; Li, Pu

doi:10.1016/0165-4608(92)90343-7

Cited by 9 publications

(4 citation statements)

References 15 publications

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“…A loss of the chromosomal region 17p.13.1 or a complete loss of chromosome 17p was detected in only 7,7% of the cases analyzed 39 . Two additional studies reported cytogenetic analyses of single cases (n=3) of penile squamous cell carcinoma and they also reported rarely abnormalities of chromosome 17 40 , 41 . Interestingly, the generally detected high frequency of p53 expression in penile tumors often associated with HPV negativity was not reflected in a concordant high frequency of p53 mutations yet.…”

Section: Discussionmentioning

confidence: 99%

P53 Codon 72 Polymorphism and Risk for Squamous Cell Carcinoma of the Penis: A Caucasian Case-Control Study

et al. 2018

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Squamous cell carcinoma of the penis is a rare but often aggressive disease. A large proportion of penile cancers are associated with HPV infection, mainly with HPV high-risk subtypes 16 and 18. From other HPV-related malignancies a link between a functional SNP in the p53 gene (rs1042522, p.Arg72Pro) and a higher disease risk in the presence of HPV is documented. The p53 p.Arg72 variant was described as a risk factor for developing a malignancy in combination with the presence of HPV as the p.72Arg variant is more prone to HPV E6 protein-mediated degradation than the p.72Pro variant. For penile carcinoma there are only sparse data available on this topic. We therefore analyzed the distribution of this p53 codon 72 SNP in a cohort of 107 penile cancer patients and a healthy control group (n=194) using Restriction Fragment Length Polymorphism (RFLP) analysis. After DNA isolation a PCR amplicon including the variant nucleotide was generated. Based on the variant nucleotide this amplicon can be cleaved into two parts or remain unaffected by a restriction enzyme. Subsequent electrophoresis allowed the discrimination of SNP alleles in the investigated sample. Comparison of the allelic variants revealed no significant differences in the distribution of this SNP between cases and controls (p=0,622). There was also no difference in SNP distribution between cases with/without HPV infection (p=0,558) or histologic variants (p=0.339). In order to strengthen the impact of our data we performed a combined analysis of all published data on this topic with our results. This ended up in SNP distribution data from 177 cases and 1149 controls. Overall, there were also no significant differences in the allelic distribution of the p53 codon 72 SNP between either cases and controls (p=0,914) or HPV-positive and HPV-negative cases (p=0,486). From this most comprehensive data available to date we conclude that there is no influence of the p53 codon 72 SNP on the risk of development of penile carcinoma in Caucasians even in the presence of HPV.

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Section: Discussionmentioning

confidence: 99%

P53 Codon 72 Polymorphism and Risk for Squamous Cell Carcinoma of the Penis: A Caucasian Case-Control Study

et al. 2018

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“…This marker contains two copies of a small segment of proximal long arm euchromatin (22q 11.2), thus resulting in tetrasomy for 22q 11.2. Clinically, these patients usually present with cat-eye syndrome (230)(231)(232). Characteristic features inc1ude craniofacial anomalies (vertical coloboma of the iris, which gives the syndrome its name; coloboma of the choroid or optic nerve; preauricular skin tags/pits; down-slanting palpebral fissures) and anal atresia with rectovestibular fistula.…”

Section: Other Partial Autosomal Aneuploidies Supernumerary Marker Chmentioning

confidence: 99%

“…Lung (224) Salivary gland (225) Squamous cell carcinoma Anal canal (226) Esophagus (227) Head and neck (oropharynx, larynx, pyriform sinus) (228,229) Lung (230,231) Penis (232) Rearrangements of 1,4,6,11,14,22 Rearrangements involving 19p13 t(6;9)(q23;p21), rearrangements of 9p21, 17p, 17p Hyperdiploid with rearrangements Polyclonal changes, +6, del(9)(q22), +12, +18, -X,-Y Skin (233) Vulva (234) Transitiona1 cell carcinoma B1adder (235) Kidney (199) Undifferentiated carcinoma, 1arge cell Lung (236) Undifferentiated carcinoma, small cell Lung (237,238) Wilms tumor (239) Benign mesenchymal neoplasms Chondromalchondrob1astomal chondromyxoid fibroma (243) Endometria1 polyp (244) Fibroma Bone (245) Ovary (246) Fibromatosis/desmoid tumor (247,248) Hamartoma Liver (249) Pu1monary chondroid (250,251) Skeletal (osteocartilaginous exostoses) (252) Hemangioma (253) Hibernoma (254) …”

Section: Table 16 Recurrent Structural and Numerical Chromosome Aberrmentioning

confidence: 99%

The Principles of Clinical Cytogenetics

1999

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“…Squamous cell carcinomas (SCCs) of the penis are rare tumors in men, and cytogenetic data have been reported for only three cases (Xiao et al, 1992; Ornellas et al, 1998, 1999). Low mitotic activity, poor growth in cell culture, presence of large areas of necrosis, and contamination with bacterial and other microbial agents have contributed to this lack of cytogenetic data.…”

Section: Introductionmentioning

confidence: 99%

Genetic imbalances in 26 cases of penile squamous cell carcinoma

Alves

Heller

Fiedler

et al. 2001

Genes Chromosomes & Cancer

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To obtain more information on chromosomal changes in the up-to-now poorly studied tumor class of penile squamous cell carcinoma (SCC), we performed a comparative genomic hybridization study of 26 cases of this rare tumor. DNA sequence copy number alterations (CNAs) very similar to those detected in other SCC types, such as oral and esophageal SCC, were noted. The most common copy number gains were found in 8q24, 16p11-12, 20q11-13, 22q, 19q13, and 5p15, and the most common deletions were detected in 13q21-22, 4q21-32, and along the X chromosome. Classifying the patients according to the number of CNAs showed a possible correlation with clinical outcome.

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Cytogenetic abnormalities in a squamous cell carcinoma of the penis

Cited by 9 publications

References 15 publications

P53 Codon 72 Polymorphism and Risk for Squamous Cell Carcinoma of the Penis: A Caucasian Case-Control Study

P53 Codon 72 Polymorphism and Risk for Squamous Cell Carcinoma of the Penis: A Caucasian Case-Control Study

The Principles of Clinical Cytogenetics

Genetic imbalances in 26 cases of penile squamous cell carcinoma

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