Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese

Ewing, Laura; Pathak, Rupak; Landes, Reid D.; Skinner, Charles M.; Binz, Regina Lichti; Young, S. Y.; Riklon, Sheldon; Stahr, Shelbie; Su, Joseph; Boerma, Marjan; McElfish, Pearl A.; Hauer‐Jensen, Martin; Koturbash, Igor

doi:10.1080/09553002.2022.2110319

Cited by 6 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accumulating evidence indicates that epigenetic reprogramming is not only a consequence of disease but often serves as a driving mechanism in the pathogenesis of diseases [36]. Various environmental stressorsfrom heavy metals to ionizing radiation-are known to affect DNA methylation and DNA methylation machinery [26,37,38]. Exposure to PM, from coarse PM 10 particles to nanoparticles has been associated with altered DNA methylation in vitro, in vivo, and in humans [39][40][41].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Climate Change and New Challenges for Rural Communities: Particulate Matter Matters

Miousse,

Hale,

Alsbrook

et al. 2023

Sustainability

Self Cite

View full text Add to dashboard Cite

Climate change presents multiple challenges to rural communities. Here, we investigated the toxicological potential of the six types of particulate matter most common to rural Arkansas: soil, road, and agricultural dusts, pollen, traffic exhaust, and particles from biomass burning in human small airway epithelial cells (SAECs). Biomass burning and agricultural dust demonstrated the most potent toxicological responses, exhibited as significant (p < 0.05) up-regulation of HMOX1 (oxidative stress) and TNFα (inflammatory response) genes as well as epigenetic alterations (altered expression of DNA methyltransferases DNMT1, DNMT3A, and DNMT3B, enzymatic activity, and DNA methylation of alpha satellite elements) that were evident at both 24 h and 72 h of exposure. We further demonstrate evidence of aridification in the state of Arkansas and the presence of winds capable of transporting agricultural dust- and biomass burning-associated particles far beyond their origination. Partnerships in the form of citizen science projects may provide important solutions to prevent and mitigate the negative effects of the rapidly evolving climate and improve the well-being of rural communities. Furthermore, the identification of the most toxic types of particulate matter could inform local policies related to agriculture, biomass burning, and dust control.

show abstract

Section: Discussionmentioning

confidence: 99%

“…DNA methylation of retrotransposons LINE-1 and Alu was assessed via methylationsensitive qRT-PCR as previously described [16,17,26].…”

Section: Dna Methylation Analysismentioning

confidence: 99%

Climate Change and New Challenges for Rural Communities: Particulate Matter Matters

Miousse,

Hale,

Alsbrook

et al. 2023

Sustainability

Self Cite

View full text Add to dashboard Cite

show abstract

“…As evident from the discussion above, exposure to ionizing radiation (including high-LET radiation) leaves scars, not only as mutations and irreparable damage to DNA itself, but also as permanently present alterations of DNA methylation within repetitive sequences (i.e., within the promoter regions of LINE-1 elements). Importantly, these altered patterns of DNA methylation can be detected not only in experimental systems, but also in humans previously exposed to ionizing radiation [100,102,108].…”

Section: Epigeneticsmentioning

confidence: 99%

A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment

Afshari,

Koturbash,

Boerma

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

Astronauts in space are subject to continuous exposure to ionizing radiation. There is concern about the acute and late-occurring adverse health effects that astronauts could incur following a protracted exposure to the space radiation environment. Therefore, it is vital to consider the current tools and models used to describe and study the organic consequences of ionizing radiation exposure. It is equally important to see where these models could be improved. Historically, radiobiological models focused on how radiation damages nuclear deoxyribonucleic acid (DNA) and the role DNA repair mechanisms play in resulting biological effects, building on the hypotheses of Crowther and Lea from the 1940s and 1960s, and they neglected other subcellular targets outside of nuclear DNA. The development of these models and the current state of knowledge about radiation effects impacting astronauts in orbit, as well as how the radiation environment and cellular microenvironment are incorporated into these radiobiological models, aid our understanding of the influence space travel may have on astronaut health. It is vital to consider the current tools and models used to describe the organic consequences of ionizing radiation exposure and identify where they can be further improved.

show abstract

“…As evident from the discussion above, exposure to ionizing radiation (including high-LET radiation) leaves scars not only as mutations and irreparable damage on DNA itself but also permanently present alterations of DNA methylation within repetitive sequences (i.e., within the promoter regions of LINE-1 elements). Importantly, these altered patterns of DNA methylation can be detected not only in experimental systems, but also in humans previously exposed to ionizing radiation [93,95,101].…”

Section: Epigeneticsmentioning

confidence: 99%

A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment

Afshari,

Koturbash,

Boerma

et al. 2023

Preprint

View full text Add to dashboard Cite

Astronauts in space are subject to a continuous bombardment of ionizing radiation. The Earth's magnetic field and the ISS shield some biologically damaging particles traveling through. Still, travel beyond low-Earth orbit and extravehicular activities are exceedingly more dangerous and there is a concern for the acute and late-occurring adverse health effects befalling astronauts. So, it is vital to consider the current tools and models used to describe and study the organic consequences of ionizing radiation exposure. It is equally important to see where these models may improve. This article reviews the historical development and current state of knowledge of radiation effects impacting astronauts in orbit. We explain the space radiation environment, cellular microenvironment, and how these may be incorporated in radiobiological models to aid in our understanding of the influence space travel may have on astronaut health. The topics discussed in this paper include a review of DNA damage and repair mechanisms and the numerical models that aim to explain the biological effects resulting from ionizing radiation damage. Historically, radiobiological models focused on how radiation damages nuclear DNA, built upon the hypotheses of Crowther and Lea in the 1940s and 1960s, and neglected other sub-cellular targets outside of nuclear DNA.

show abstract

Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese

Cited by 6 publications

References 48 publications

Climate Change and New Challenges for Rural Communities: Particulate Matter Matters

Climate Change and New Challenges for Rural Communities: Particulate Matter Matters

A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment

A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment

Contact Info

Product

Resources

About