Cytogenetic Effects Induced by the Natural Pyrethrins and the Synthetic Lambda Cyhalothrin in Mice in Vivo.

Fahmy, Maha A.; Abdalla, E. F.

doi:10.1508/cytologia.66.139

Cited by 22 publications

(2 citation statements)

References 30 publications

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“…This insecticide has been shown to induce genotoxicity, micronucleus formation, and chromosomal aberrations in rat bone marrow cells, in addition to causing sexual dysfunction in male rats (Campana et al, ; Fahmy and Abdallah, ; Ratnasooriya et al, ; Çelik et al, ). Recent studies have reported that reactive oxygen species (ROS) are involved in LCT‐induced toxicity (Fetoui et al, ).…”

Section: Introductionmentioning

confidence: 99%

Reproductive toxicity and histopathological changes induced by lambda‐cyhalothrin in male mice

Al‐Sarar

Abobakr

Bayoumi

et al. 2012

Environmental Toxicology

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Lambda-cyhalothrin (LCT) is a widely used broad-spectrum pyrethroid insecticide. Oral LCT administration to adult male mice at 3 doses (0.2, 0.4, and 0.8 mg/kg/day) for 6 weeks caused a significant reduction in the weight of the seminal vesicles. The epididymal sperm count was lower in mice that received at the highest dose than in control mice. However, the proportions of live and motile spermatozoa were reduced at both the medium and the high doses compared with control mice. All doses induced an increase in the number of morphologically abnormal spermatozoa. Histopathological observations of the testes, liver, kidneys, and spleen showed dose-related degenerative damage in LCT-treated mice. The results indicate that LCT has reproductive toxicity, hepatotoxicity, nephrotoxicity, and splenotoxicity in male mice at the tested doses. © 2012 Wiley Periodicals, Inc. Environ Toxicol 29: 750-762, 2014.

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Section: Introductionmentioning

confidence: 99%

Reproductive toxicity and histopathological changes induced by lambda‐cyhalothrin in male mice

Al‐Sarar

Abobakr

Bayoumi

et al. 2012

Environmental Toxicology

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“…Such chromatin bridges have also been reported to be induced by several chemicals including organophosphorus pesticides (Fahmy andAbdulla 2001, George andGhareeb 2001). Inhibition of ATPase by the mutagen might be a cause of spindle disorientation (Reddy and Bashamohideem 1991) leading to vagrancies as well as Cmetaphase.…”

Section: Discussionmentioning

confidence: 99%

Meiotic Anomalies in Sodium Azide Induced Tetraploid and Mixoploid of Trigonella foenum-graecum

Kapoor

Srivastava

2010

CYTOLOGIA

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Summary Mutagen-induced polyploidy can be considered to be a system of increasing genotypic plasticity so that aberrations at the genic and chromosomal level are easily tolerated by the plants. A tetraploid and a mixoploid mutant was induced in Trigonella foenum-graecum by sodium azide. Healthy seeds of Trigonella were treated with different doses of sodium azide. In M 2 screening, we found variants at 0.15% treatment for 4 h and at 0.25% treatment for 2 h and they were studied for morphological characters, meiotic behaviour, pollen sterility and stomata frequency. They were confirmed as tetraploid and mixoploid respectively and their surviving M 3 progeny was further studied on the same line. Meiotic studies showed different types of abnormalities for both. In mixoploid, the RAR increased from M 2 to M 3 but in tetraploid plant it decreased in M 3 generation. The number of chiasma per chromosome was reduced in M 3 generation for both the mutants. A comparison of the different anomalies in 2 generations of the tetraploid and mixoploid helps us to understand the reason for very high pollen sterility and negligible seed set in the tetraploid. Stickiness was increased in both, but the relative increase was less in tetraploid. Stickiness has been considered as a natural method of ameliorating stress and hence may be responsible for better performance of mixoploid. Laggards and spindle disorientation was significantly higher in the tetraploid as compared to the mixoploid.

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Pyrethrum [MAK Value Documentation in German language, 2008]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 45. Lieferung, Ausgabe 2008 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Cytogenetic Effects Induced by the Natural Pyrethrins and the Synthetic Lambda Cyhalothrin in Mice in Vivo.

Cited by 22 publications

References 30 publications

Reproductive toxicity and histopathological changes induced by lambda‐cyhalothrin in male mice

Reproductive toxicity and histopathological changes induced by lambda‐cyhalothrin in male mice

Meiotic Anomalies in Sodium Azide Induced Tetraploid and Mixoploid of Trigonella foenum-graecum

Pyrethrum [MAK Value Documentation in German language, 2008]

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