2010
DOI: 10.1128/cvi.00485-09
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Cytokine Protein Expression Levels in Tracheobronchial Lymph Node Homogenates of Pigs Infected with Pseudorabies Virus

Abstract: Pseudorabies virus (PRV) is a neurotropic alphaherpesvirus that produces fatal encephalitis in newborn pigs

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Cited by 15 publications
(13 citation statements)
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“…Virus, animals, and experimental design. The animal study, conducted according to the National Animal Disease Center Institutional Animal Care and Use Guidelines, has been previously described by Miller et al 1 Briefly, 40 conventionally raised 4-to 5-week-old pigs, free of clinical disease, were purchased from a Porcine Circovirus 2-, Swine Influenza Virus-, Porcine Respiratory and Reproductive Virus-, and PRV-negative herd. Pigs were equally allotted to two equal treatment groups, and each group was housed in an isolation room for about one week prior to the beginning of the experiment.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Virus, animals, and experimental design. The animal study, conducted according to the National Animal Disease Center Institutional Animal Care and Use Guidelines, has been previously described by Miller et al 1 Briefly, 40 conventionally raised 4-to 5-week-old pigs, free of clinical disease, were purchased from a Porcine Circovirus 2-, Swine Influenza Virus-, Porcine Respiratory and Reproductive Virus-, and PRV-negative herd. Pigs were equally allotted to two equal treatment groups, and each group was housed in an isolation room for about one week prior to the beginning of the experiment.…”
Section: Methodsmentioning
confidence: 99%
“…Pseudorabies virus (PRV) strain FS268 virus-induced pneumonia in young pigs provides a model for examining the response of the immune system to a respiratory pathogen. 1 PRV is a neurotropic alphaherpesvirus 2 that produces fatal encephalitis in newborn pigs, respiratory disorders in fattening pigs, and reproductive failure in sows. There are three classes of swine in the US as defined in the USDA Veterinary Services PRV Program Standards: feral swine that are wild and free roaming, transitional swine that are considered to be owned by someone and may enter the food chain, and commercial swine that are raised in an environment in which there is no contact with feral swine.…”
Section: Introductionmentioning
confidence: 99%
“…These data indicate that NMBR may be involved in the pathological or host defence processes of PR8/IAV infection. It is well known that many viruses are capable of modulating the expression of inflammatory cytokines (e.g., IL-6), thus allowing the virus to establish a successful infection [2931]. Although it appears from the data presented here that induction of NMBR in response to IAV/PR8 infection is indeed part of the host innate response and is detrimental to the virus, further studies are necessary to confirm these findings.…”
Section: Discussionmentioning
confidence: 62%
“…Four weeks after vaccination, pigs were challenged intranasally with 2 mL HN1201 (10 7.0 TCID 50 $mL -1 ) to assess protection. After challenge, pigs were observed and scored daily for 7 days for clinical signs of disease as previously described [15,16] . At 14 days post challenge (dpc), all surviving pigs were euthanized, and different tissue samples were collected for histopathology and immunohistochemistry examination.…”
Section: Preparation Of Gb Subunit Vaccine and Animal Experimentsmentioning
confidence: 99%