Cytokine responses in acute and persistent human parvovirus B19 infection

Isa, Adiba; Lundqvist, Anders; Lindblom, Anna; Tolfvenstam, Thomas; Broliden, Kristina

doi:10.1111/j.1365-2249.2006.03286.x

Cited by 26 publications

(12 citation statements)

References 24 publications

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“…Isa, et al reported that elevated levels of the Th1 cytokines such as interleukin 12 (IL-12) and IL-15 were evident at the time of the initial peak of parvovirus B19 viral load during acute infection, and some of these patients had a sustained Th1 cytokine response during followup (20 to 130 weeks after acute infection) 2 . They also showed that the Th1 cytokine response correlated with the previously identified sustained CD8+ T cell response and viremia 2 .…”

Section: To the Editorsupporting

confidence: 58%

Association of Parvovirus B19 Infection with Systemic Lupus Erythematosus: Role of Th1 Predominance

Park

Kim

et al. 2011

J Rheumatol

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Section: To the Editorsupporting

confidence: 58%

Association of Parvovirus B19 Infection with Systemic Lupus Erythematosus: Role of Th1 Predominance

Park

Kim

et al. 2011

J Rheumatol

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“…In contrast, cytokines associated with a Th2 type of immune response (IL-4, IL-5 and IL-10) as well as an IFN-response remained low during the observation time. Despite the lack of Th2 cytokines the patients developed normal B19-specific IgG levels, so antibodies may have been induced by a lowgrade IL-6 response as well as other cytokines, for example, TGF- [281].…”

Section: Adaptive Immunity Cellular T-cell-mediated Immunementioning

confidence: 96%

Parvovirus B19 Achievements and Challenges

Gallinella

2013

ISRN Virology

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Parvovirus B19 is a widespread human pathogenic virus, member of the Erythrovirus genus in the Parvoviridae family. Infection can be associated with an ample range of pathologies and clinical manifestations, whose characteristics and outcomes depend on the interplay between the pathogenetic potential of the virus, its adaptation to different cellular environments, and the physiological and immune status of the infected individuals. The scope of this review is the advances in knowledge on the biological characteristics of the virus and of virus-host relationships; in particular, the interactions of the virus with different cellular environments in terms of tropism and ability to achieve a productive replicative cycle, or, on the contrary, to establish persistence; the consequences of infection in terms of interference with the cell physiology; the process of recognition of the virus by the innate or adaptive immune system, hence the role of the immune system in controlling the infection or in the development of clinical manifestations. Linked to these issues is the continuous effort to develop better diagnostic algorithms and methods and the need for development of prophylactic and therapeutic options for B19V infections.

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“…The VP1u-specific IFN-␥ response is predominant in recently infected subjects, while VP1u-specific IFN-␥ and IL-10 responses are absent in remotely infected patients despite the presence of B cell immunity against VP1u (392). Examination of cytokine responses to B19V infection shows that they are of the Th1 type, with IL-2, IL-12, and IL-15 being detected in acutely infected patients, correlating with the sustained CD8 ϩ T cell response (393). There is no imbalance of cytokine patterns in persistent infection, except for an elevated IFN-␥ response.…”

Section: Immune Response Adaptive Immune Responsementioning

confidence: 98%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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Cytokine responses in acute and persistent human parvovirus B19 infection

Abstract: SummaryThe aim of this study was to characterize the proinflammatory and T helper (

Cited by 26 publications

References 24 publications

Association of Parvovirus B19 Infection with Systemic Lupus Erythematosus: Role of Th1 Predominance

Association of Parvovirus B19 Infection with Systemic Lupus Erythematosus: Role of Th1 Predominance

Parvovirus B19 Achievements and Challenges

Human Parvoviruses

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