Cytologic Diagnostic Accuracy in Pleomorphic Adenoma of the Salivary Glands During 2 Periods

Viguer, José M.; Jiménez‐Heffernan, José A.; Vicandi, Blanca; López‐Ferrer, Pilar; Navarro, Marta

doi:10.1159/000325676

Cited by 18 publications

(30 citation statements)

References 23 publications

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“…In previous studies, only 29% to 50% of cases had a preoperative FNA diagnosis of malignancy . Conversely, various degrees of cellular atypia are not uncommon in benign pleomorphic adenomas and may be overcalled as malignant . In the current study, there was 1 carcinoma ex pleomorphic adenoma of the 4 myoepithelial subtype cases of focal atypia on histologic follow‐up.…”

Section: Discussioncontrasting

confidence: 41%

“…However, this feature has been noted in benign basal cell adenoma (Fig. C,D), pleomorphic adenoma, and myoepithelioma, and this may lead to false‐positive diagnoses . Hyaline globules also have been observed in other malignant tumors like epithelial‐myoepithelial carcinoma and polymorphous adenocarcinoma of minor salivary glands .…”

Section: Discussionmentioning

confidence: 97%

“…The morphologic heterogeneity may occur in a single tumor type because of tumor differentiation, metaplasia, tissue change, or reaction. For example, it is not uncommon to observe squamous metaplasia or cystic change in a pleomorphic adenoma, which causes diagnostic confusions . Moreover, even a single cell type can present with diverse cytomorphology.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Subtyping salivary gland neoplasm of uncertain malignant potential based on cell type demonstrates differential risk of malignancy

Hang

Alruwaii

Zeng

et al. 2018

Cancer Cytopathology

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BACKGROUND The newly unveiled Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has proposed salivary gland neoplasm of uncertain malignant potential (SUMP) as an indeterminate category. The category is reserved for fine‐needle aspiration (FNA) cases that are diagnostic of a salivary gland neoplasm but cannot be further designated as a specific tumor type. The objective of the current study was to evaluate the clinical utility of subtyping SUMP cases based on different cell types. METHODS A retrospective search of cytology databases at 2 institutions for salivary gland FNAs from 2006 through 2017 was conducted. The cytologic diagnosis of each case was reclassified according to the MSRSGC. Histologic follow‐up was retrieved for correlation. Cases reclassified as SUMP that had a follow‐up pathologic diagnosis were subject to cytology review and subtyping into oncocytic/squamoid, basaloid, or myoepithelial subtypes based on cytomorphology. The risk of malignancy (ROM) for each subtype was analyzed. RESULTS There were 92 SUMP cases, which comprised 5.9% of 1560 consecutive salivary gland FNAs within the 12‐year study period. Histologic follow‐up was available for 59 patients. After cytology review, there were 18 cases (30.5%) of oncocytic/squamoid subtype, 25 (42.4%) of basaloid subtype, and 16 (27.1%) of myoepithelial subtype. Pathologic correlation revealed an ROM of 61.1% (11 of 18 cases) for the oncocytic/squamoid subtype, 40.0% (10 of 25 cases) for the basaloid subtype, and 18.8% (3 of 16 cases) for the myoepithelial subtype. The differences in ROM among the 3 subtypes were statistically significant (P = .0476). CONCLUSIONS Subtyping SUMP cases into categories based on cell type demonstrated differential ROMs for better clinical stratification. Future prospective studies are mandatory to confirm this finding.

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Section: Discussioncontrasting

confidence: 41%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Subtyping salivary gland neoplasm of uncertain malignant potential based on cell type demonstrates differential risk of malignancy

Hang

Alruwaii

Zeng

et al. 2018

Cancer Cytopathology

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“…Cytologic diagnostic accuracy of pleomorphic adenoma is high, and major errors may diminish if special attention is paid to some pitfalls. Sampling limitations and interpretive difficulties may prevent differentiation from a few cases of carcinoma ex-pleomorphic adeno- ma and adenoid cystic carcinoma, according to a recent study (14). A retrospective study evaluated the usefulness and accuracy of fine-needle aspiration biopsy in the diagnosis of parotid gland masses and the results revealed 65 malignant tumors and 163 benign lesions (150 neoplasms and 13 nonneoplastic lesions).…”

Section: Pleomorphic Adenoma 01mentioning

confidence: 99%

Accuracy, sensitivity and specificity of fine needle aspiration biopsy in salivary gland tumours: A retrospective study

Stramandinoli

Sassi²,

Pedruzzi³

et al. 2009

Med Oral

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15 (1):e32-7. Accuracy, sensitivity and specificity of the fine needle aspiration http://www.medicinaoral.com/medoralfree01/v15i1/medoralv15i1p32.pdf AbstractObjective: The aim of this study was to evaluate the diagnostic accuracy, sensitivity and specificity of fine needle aspiration biopsies (FNAB) of salivary gland tumours performed at the Erasto Gaertner Hospital over the course of a four year period. Study design: A retrospective study was carried out between 2001-2005 to review the cases of patients with salivary gland tumours who had undergone pre-operative FNAB and had been diagnosed during post-operative histopathology examination. Results: A total of 106 cases of salivary gland tumours were considered for this study, but 27 cases (25.5%) of the samples were considered unsatisfactory for analysis. The sensitivity, specificity and accuracy were calculated considering only the 79 benign and malignant cases in which FNAB provided sufficient samples for analysis. Based on these data, the value of sensitivity was 68.2% (15/22), specificity was 87.7% (50/57), accuracy was 82.3% (65/79), positive predictive value was 68.2% (15/22) and negative predictive value was 87.7% (50/57). Conclusions: Despite the high rate of inadequate samples obtained in the FNAB in this study, the technique offers high specificity, accuracy and acceptable sensitivity.

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“…However, there were no patients postoperatively diagnosed with carcinoma ex pleomorphic adenoma in the malignancy group. Morphologic variations often pose difficulties in the cytologic diagnosis of the portion of tumor sampled, resulting in a carcinoma ex pleomorphic adenoma being misdiagnosed as a pleomorphic adenoma or other tumor type . Diagnostic difficulties may be caused by the similar cytologic features of different salivary gland tumors.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes of patients with salivary gland carcinomas preoperatively misdiagnosed as benign lesions

et al. 2013

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Cytologic Diagnostic Accuracy in Pleomorphic Adenoma of the Salivary Glands During 2 Periods

Cited by 18 publications

References 23 publications

Subtyping salivary gland neoplasm of uncertain malignant potential based on cell type demonstrates differential risk of malignancy

Subtyping salivary gland neoplasm of uncertain malignant potential based on cell type demonstrates differential risk of malignancy

Accuracy, sensitivity and specificity of fine needle aspiration biopsy in salivary gland tumours: A retrospective study

Clinical outcomes of patients with salivary gland carcinomas preoperatively misdiagnosed as benign lesions

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