Cytologic Evaluation of Primary Malignant Vascular Tumors of the Liver

Cho, Nam Hoon; Lee, Kwang Gil; Jeong, Mi Gyoung

doi:10.1159/000332861

Cited by 34 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rare nature of the tumor and the reluctance of many radiologists or cytopathologists to perform FNA out of concern for possible serious bleeding complications have resulted in few cytologic descriptions of hepatic angiosar-coma. [13][14][15][16][17] Open and percutaneous core liver biopsy has been associated with massive intra-abdominal bleeding. Fine-needle biopsy, however, has been suggested as a safe procedure for the diagnosis of hepatic AS, with low risk of hemorrhage.…”

Section: Spindle-cell Lesions Of Livermentioning

confidence: 99%

“…Numerous variable, and sometimes contradictory, cytologic features have likewise been reported. [13][14][15][16][17] These features include low to high cellularity, few to numerous single cells, presence of hemosiderin, vaculolated cytoplasm, erythrophagocytosis, and prominent bloody background. Even in the absence of high cellularity, the presence of pleomorphic malignant cells in a bloody background is suggestive of AS.…”

Section: Spindle-cell Lesions Of Livermentioning

confidence: 99%

See 1 more Smart Citation

Spindle‐cell lesions of the liver: Diagnosis by fine‐needle aspiration biopsy

Guy

Yuan

Ballo

2001

Diagnostic Cytopathology

View full text Add to dashboard Cite

Rarely, spindle-cell lesions in liver fine-needle aspiration biopsies (FNABs) are encountered. A retrospective review of our experience with lesions that are mesenchymal in origin or appearance was undertaken to elucidate the frequency and spectrum of these lesions. Image-guided liver FNABs performed over a 3-year period (n = 585) at our institution (1996-1998) were retrospectively evaluated. Cytologic smears, cell block preparations, and clinical follow-up of lesions with spindle-cell morphology were reviewed. Twenty-nine of 585 cases were of spindle-cell morphology (5%). Hemangiomas (n = 12, 41%) and metastatic sarcomas (n = 6, 21%) comprised the largest categories, followed by granulomatous inflammation (n = 3, 10%). Other cases included primary angiosarcoma and fibrolamellar hepatocellular carcinoma. The most frequent spindle-cell liver lesion encountered is hemangioma, followed by metastatic leiomyosarcoma and granulomatous hepatitis. Awareness of diagnostic possibilities, special attention to specimen adequacy, and use of ancillary procedures can maximize diagnostic yield.

show abstract

Section: Spindle-cell Lesions Of Livermentioning

confidence: 99%

Section: Spindle-cell Lesions Of Livermentioning

confidence: 99%

Spindle‐cell lesions of the liver: Diagnosis by fine‐needle aspiration biopsy

Guy

Yuan

Ballo

2001

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

Angiosarcoma after breast-conserving therapy: Fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates

Gherardi

Rossi

Perrone

et al. 2005

Cancer

View full text Add to dashboard Cite

Background: Over 45 million Americans suffer from recurrent headaches, and an estimated $11.9 million was spent on doctor's visits for rhinogenic pain last year. Sphenopalatine blocks have been described for various facial pain syndromes, but their use and the type of blockade agents remain controversial. The objective of this study was to demonstrate that endoscopic nerve blocks, using a mixture of bupivicaine and triamcinolone‐40, injected into the anterior ethmoid or sphenopalatine regions, can be a relative safe and effective option for refractory pain. Methods: The charts of all patients undergoing endoscopic neural blockade, in a private practice setting from 1998 to 2008 were retrospectively reviewed. A 1:1 mixture of 0.5% bupivicaine and triamcinolone acetonide injectable suspension was injected into the patients' anterior ethmoid or sphenopalatine neural distribution, or both, depending on the pain distribution. Charts were reviewed to assess outcomes and any adverse events from nerve blocks. Results: A total of 882 nerve blocks were administered to 147 patients, over the course of 431 office visits. Four mild complications, 2 moderate complications, and no severe or permanent complications were noted. No permanent visual complications were observed. Of all the charts, 85% had documented effects of the nerve block at follow‐up. Of those, 81.3% claimed improvement, 17.9% reported feeling the same, and 0.79% stated they had worse pain. Conclusion: Endoscopic neural blockade appears to be a relatively safe and viable option in the treatment of refractory headache and facial pain with a rhinogenic component. © 2012 ARS‐AAOA, LLC.

show abstract

Primary malignant hepatic epithelioid hemangioendothelioma

Mehrabi

Kashfi

Fonouni

et al. 2006

Cancer

424

295

View full text Add to dashboard Cite

Malignant hepatic epithelioid hemangioendothelioma (HEH) is a rare malignant tumor of vascular origin with unknown etiology and a variable natural course.The authors present a comprehensive review of the literature on HEH with a focus on clinical outcome after different therapeutic strategies. All published series on patients with HEH (n ¼ 434 patients) were analyzed from the first description in 1984 to the current literature. The reviewed parameters included demographic data, clinical manifestations, therapeutic modalities, and clinical outcome. The mean age of patients with HEH was 41.7 years, and the male-tofemale ratio was 2:3. The most common clinical manifestations were right upper quadrant pain, hepatomegaly, and weight loss. Most patients presented with multifocal tumor that involved both lobes of the liver. Lung, peritoneum, lymph nodes, and bone were the most common sites of extrahepatic involvement at the time of diagnosis. The most common management has been liver transplantation (LTx) (44.8% of patients), followed by no treatment (24.8% of patients), chemotherapy or radiotherapy (21% of patients), and liver resection (LRx) (9.4% of patients). The 1-year and 5-year patient survival rates were 96% and 54.5%, respectively, after LTx; 39.3% and 4.5%, respectively, after no treatment, 73.3% and 30%, respectively, after chemotherapy or radiotherapy; and 100% and 75%, respectively, after LRx. LRx has been the treatment of choice in patients with resectable HEH. However, LTx has been proposed as the treatment of choice because of the hepatic multicentricity of HEH. In addition, LTx is an acceptable option for patients who have HEH with extrahepatic manifestation. Highly selected patients may be able to undergo living-donor LTx, preserving the donor pool. The role of different adjuvant therapies for patients with HEH remains to be determined.

show abstract

Cytologic Evaluation of Primary Malignant Vascular Tumors of the Liver

Cited by 34 publications

References 5 publications

Spindle‐cell lesions of the liver: Diagnosis by fine‐needle aspiration biopsy

Spindle‐cell lesions of the liver: Diagnosis by fine‐needle aspiration biopsy

Angiosarcoma after breast-conserving therapy: Fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates

Primary malignant hepatic epithelioid hemangioendothelioma

Contact Info

Product

Resources

About