Cytologic features and histologic correlations of microacinar and microtrabecular types of well-differentiated hepatocellular carcinoma in fine-needle aspiration biopsy

Yang, Grace C. H.; Yang, Guang; Tao, Liang Che

doi:10.1002/cncr.20000

Cited by 26 publications

(16 citation statements)

References 30 publications

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“…The three cases of HCC illustrated here were so welldifferentiated that their malignant nature was not realized until clinical follow-up. 30 …”

Section: Resultsmentioning

confidence: 99%

“…This physical feature will be particularly helpful during on-site assessment for FNA biopsies to guide radiologists to the right nodule, and to recognize HCC that are so welldifferentiated that they did not meet the classic cytologic criteria for HCC. 30 Another issue is that the interventional radiologists may have selection bias in deciding which type of hepatic lesions to be sampled by needlecore biopsy or FNA biopsy. However, the selection bias has minimal impact in terms of the observation reported.…”

Section: Discussionmentioning

confidence: 99%

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Distinguishing well-differentiated hepatocellular carcinoma from benign liver by the physical features of fine-needle aspirates

Yang

Tao

2004

Modern Pathology

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Distinguishing well-differentiated hepatocellular carcinoma (HCC) from benign hepatic lesions is challenging for pathologists in limited diagnostic material such as needle-core tissue biopsy and fine-needle aspiration (FNA) biopsy. The objective of this study is to test a hypothesis that the fortification of liver by reticulin along single cell plates should protect benign hepatic lesions from breakdown by the force of aspiration and smearing, whereas the decreased reticulin in well-differentiated HCC would result in finely granular FNA smear. The study involved FNA biopsies of 67 cases of well-differentiated HCC and 109 cases of benign hepatic lesions, including cirrhosis (22), liver cell adenoma (8), steatosis (7), focal nodular hyperplasia (6), liver with cholestasis (6), and unremarkable liver sampled from nodular hepatic lesions consistent with the regenerative nodules (60). A slide with the most sample from each case by gross inspection was mixed together. Two observers blinded to the diagnoses were asked to separate the slides into two groups based on smear characteristics by gross inspection. Fragments of rigid fine-needle cores was present in 109 out of 109 cases of benign hepatic lesions but absent in 61 out of 67 cases of well-differentiated HCC, which presented as finely granular smears. The difference is statistically significant. (Po0.001, df ¼ 1, v 2 ¼ 149.3). Using the physical characteristic of liver aspirates as the screening test for malignancy, the sensitivity is 91%, specificity is 100%, positive predictive value is 100%, negative predictive value is 94.8%, and efficiency is 96.6%. In conclusion, the smear characteristics of liver samples in FNA biopsy correlate to their reticulin status on histology. This physical characteristic can be used as the first clue to distinguish malignant and benign liver aspirates prior to microscopic examination.

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“…The three cases of HCC illustrated here were so welldifferentiated that their malignant nature was not realized until clinical follow-up. 30 …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Distinguishing well-differentiated hepatocellular carcinoma from benign liver by the physical features of fine-needle aspirates

Yang

Tao

2004

Modern Pathology

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“…[4][5][6][7][8][9][10][11] However, distinguishing HCC from metastatic carcinoma may pose a challenge, particularly if the tumor is poorly differentiated. Moreover, the treatment and prognosis of HCC and metastatic carcinoma are significantly different.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 FNAC smears can be rapidly stained and examined. It is the first choice for deep-seated and difficult-toreach lesions.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7]10,11 Various ancillary methods such as immunocytochemistry have been used on FNAC to further improve the diagnostic accuracy. The specificity and positive predictive value of FNAC in the diagnosis of malignant liver lesions has been shown to be close to 100% in the majority of studies and the sensitivity of the FNAC procedure generally ranges from 67% to 100%, which is similar or better than that of core needle biopsy.…”

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confidence: 99%

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Immunocytochemical diagnosis of hepatocellular carcinoma and identification of carcinomas of unknown primary metastatic to the liver on fine-needle aspiration cytologies

Onofre

Pomjanski

Buckstegge

et al. 2007

Cancer

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We successfully synthesized an exfoliated styrene–butadiene–styrene triblock copolymer (SBS)/montmorillonite nanocomposite by anionic polymerization. Gel permeation chromatography showed that the introduction of organophilic montmorillonite (OMMT) resulted in a small high‐molecular‐weight fraction of SBS in the composites, leading to a slight increase in the weight‐average and number‐average molecular weights as well as the polydispersity index. The results from 1H‐NMR revealed that the introduction of OMMT almost did not affect the microstructure of the copolymer when the OMMT concentration was lower than 4 wt %. Transmission electron microscopy and X‐ray diffraction showed a completely exfoliated nanocomposite, in which both polystyrene and polybutadiene blocks entered the OMMT galleries, leading to the dispersion of OMMT layers on a nanoscale. The exfoliated nanocomposite exhibited higher thermal stability, glass‐transition temperature, elongation at break, and storage modulus than pure SBS. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

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Special Staining Techniques

Santangelo¹,

Schaefer²,

Leavell³

et al. 2020

Veterinary Cytology

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Cytologic features and histologic correlations of microacinar and microtrabecular types of well-differentiated hepatocellular carcinoma in fine-needle aspiration biopsy

Cited by 26 publications

References 30 publications

Distinguishing well-differentiated hepatocellular carcinoma from benign liver by the physical features of fine-needle aspirates

Distinguishing well-differentiated hepatocellular carcinoma from benign liver by the physical features of fine-needle aspirates

Immunocytochemical diagnosis of hepatocellular carcinoma and identification of carcinomas of unknown primary metastatic to the liver on fine-needle aspiration cytologies

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