Cytologic features of granular cell astrocytoma in crush preparations

Arvanitis, Leonidas; Gattuso, Paolo; Iacusso, Chiara

doi:10.1002/dc.21369

Cited by 7 publications

(19 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their rarity is illustrated by the fact that there has been only one cytologic report of GCA [5]. Radiologic features of GCA may simulate malignant high-grade tumor like the present case.…”

Section: Discussionmentioning

confidence: 98%

“…Approximately 60 cases of granular cell tumors associated with astrocytomas or glioblastomas have been reported [4,5,6]. Their rarity is illustrated by the fact that there has been only one cytologic report of GCA [5].…”

Section: Discussionmentioning

confidence: 99%

“…However, precise identification may be difficult due to resource constraints related to working with frozen sections, inadequate sampling capabilities, or absence of special staining or immunohistochemistry. Only one cytologic report concerning cerebral GCA has been retrieved from the literature [5], and here, we report an additional case of cerebral GCA along with crush cytologic differential diagnosis. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Crush Cytologic Findings of a Cerebral Granular Cell Astrocytoma

Kang

Kim²,

Chung³

et al. 2012

Acta Cytologica

View full text Add to dashboard Cite

Background: Granular cell astrocytoma (GCA) is a rare variant of astrocytoma, characterized by an aggressive prognosis compared to conventional astrocytomas of the same World Health Organization grade. Intraoperative smears provide useful clues in diagnosing neuropathology, especially in rarely encountered central nervous system tumors. Case: The patient was a 53-year-old man who presented with a huge mass at the left temporal lobe with peritumoral edema on MRI. The crush smears revealed singly-scattered, large eosinophilic cells with eccentrically located nuclei as well as plump, finely-granular cytoplasm with distinct borders. Mild cellular atypia and absence of mitotic activity were noted. These cells were admixed with small mature lymphoid cells. Histology showed scattered large granular cells which were positive for glial fibrillary acidic protein. Conclusion: The most helpful imprint cytologic findings of GCA were as follows: (1) large cells containing eosinophilic granular cytoplasm rather than the foamy or bubbly cytoplasm associated with macrophages or renal cell carcinomas; (2) distinct granular cell borders in contrast to the ruffled membrane of macrophages, and (3) markedly large-sized granular cells, ranging from 60 to 100 µm in diameter.

show abstract

“…Their rarity is illustrated by the fact that there has been only one cytologic report of GCA [5]. Radiologic features of GCA may simulate malignant high-grade tumor like the present case.…”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Crush Cytologic Findings of a Cerebral Granular Cell Astrocytoma

Kang

Kim²,

Chung³

et al. 2012

Acta Cytologica

View full text Add to dashboard Cite

show abstract

“…The large majority of the granular tumors pursue a benign clinical course 1. However, GCAs are a distinctive morphologic variant of infiltrative astrocytomas characterized by large, atypical, PAS-positive granular cells featuring GFAP immunopositivity 2-7…”

Section: Discussionmentioning

confidence: 99%

“…The cytologic features of GCA were described in only one report in the literature 7. Arvanitis et al7 asserts that the cytologic crush presentation was composed of small cells with indistinct cell borders and large cells with abundant eosinophilic granular cytoplasm. Our case study showed mainly large cells with abundant eosinophilic cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

Granular Cell Astrocytoma: Report of a Case

et al. 2012

View full text Add to dashboard Cite

We report here a rare case of granular cell astrocytoma. A 75-year-old man was admitted to Inha University Hospital with a three-month history of language deterioration. In a magnetic resonance imaging, a 6.5 cm-sized heterogeneous enhancing mass was seen in both the frontal lobes and the anterior genu of the corpus callosum. A stereotactic biopsy was performed. The tumor was composed of large and small round cells with abundant intracytoplasmic granules. The nuclei were bland, round to oval, and often eccentrically located. The cytoplasm of the tumor cells was positive for glial fibrillary acidic protein and S-100 protein.

show abstract

Granular Cell Astrocytoma of the Cerebrum

2016

Diagnostic Pathology: Neuropathology

View full text Add to dashboard Cite

Cytologic features of granular cell astrocytoma in crush preparations

Cited by 7 publications

References 10 publications

Crush Cytologic Findings of a Cerebral Granular Cell Astrocytoma

Crush Cytologic Findings of a Cerebral Granular Cell Astrocytoma

Granular Cell Astrocytoma: Report of a Case

Granular Cell Astrocytoma of the Cerebrum

Contact Info

Product

Resources

About