Cytolomorphological, Biochemical &amp; Radiological Correlation in Hashimoto's Thyroiditis

Khageshan, Ashwin P.; Muzaffer, Zuhallah

doi:10.5958/2394-6792.2016.00015.6

Cited by 3 publications

(6 citation statements)

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“…11,12 Autoimmune thyroiditis is a condition that requires ongoing monitoring, as it can have a significant impact on a patient's health. In our study, we evaluated 110 cases and found that the most common age group among patients was 21-30 years, which aligns with previous research by Ashwin et al 13 who also found a high incidence in the 20-40 age range. The typical presentation in our study was diffuse thyroid swelling 26 (60.47%) which bears resemblance with studies by Kartha S et al 14 (66%) and Ashwin et al 13 (50.81%).…”

Section: Discussionsupporting

confidence: 90%

“…In our study, we evaluated 110 cases and found that the most common age group among patients was 21-30 years, which aligns with previous research by Ashwin et al 13 who also found a high incidence in the 20-40 age range. The typical presentation in our study was diffuse thyroid swelling 26 (60.47%) which bears resemblance with studies by Kartha S et al 14 (66%) and Ashwin et al 13 (50.81%). Grading of autoimmune thyroiditis was done per the criteria described in (Table 5).…”

Section: Discussionsupporting

confidence: 90%

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A study of fine needle aspiration cytology findings with thyroid function test, anti-thyroid antibody, and clinical pathological parameters in cases of chronic lymphocytic thyroiditis

Marachapu

Vij²

2023

IJPO

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: Chronic lymphocytic thyroiditis is autoimmune thyroiditis; it is considered as second most common thyroid disorder diagnosed on FNAC following colloid goitre. FNAC is a reliable and efficient method for diagnosing these thyroid lesions. Chronic Lymphocytic thyroiditis frequently affects women, primarily compared to men and is commonly found with hypothyroidism, euthyroidism or every so often with hyperthyroidism. The incidence rate of Hashimoto’s thyroiditis is 1–4%, with an occurrence of 30–60/100000 population per year. Autoimmune thyroiditis can be categorised on the cytomorphological features of FNAC. To compare FNAC cytological findings with TFT in Chronic lymphocytic thyroiditis. One hundred ten patients with thyroid swellings were presented for FNAC examination, serology of TFT and Anti TPO antibodies and Ultrasonography during 2020–2021. In addition, fine needle aspiration cytology was performed using non-aspiration or aspiration techniques. TFT and Anti- TPO antibodies were performed on Avion CLX 120 auto analyser based on the Chemiluminescence method. Out of 110 cases of midline neck swelling presented in our department, Autoimmune Thyroiditis was observed in 43 cases. The most affected age group of lymphocytic thyroiditis was 21–30 years, with the male: female ratio being 1:3. Most of the patients presented with diffuse swelling and few presented with nodular swelling. The Grading of the lymphocytic thyroiditis was done by the criteria used by Bhatia et al Anti-TPO antibody was elevated in 19 cases (26.2%), and TSH was elevated in 28 cases (40.81%). These cases were diagnosed as autoimmune thyroiditis on cytology, clinically and also correlating with radiological findings. Grade 3 lymphoid infiltrate was seen in 53.33% (16/30) cases, and Grade 2, lymphoid infiltrate was seen in eight cases (62.50%). Grade 1 lymphoid infiltrate was seen in five cases (11.63%). Among 43 cases, 28 cases (65.12%) show hypothyroidism, 7 cases (16.28%) show hyper, and 8 cases (18.60%) show Euthyroidism. Among these 43 cases, 26 cases showed diffuse thyroid swelling on ultrasonography, and 7 cases showed solitary nodule. Grade 3 lymphocytic infiltration statistically correlates with anti-TPO and TSH in conjunction with ultrasonography findings of diffuse enlargement of the thyroid gland. The presence of Hurthle cell change, giant cells, anisonucleosus, and granulomas do not find to be any statistical correlation with lymphocytic thyroiditis as these cases are primarily corresponding to Grade 1 and Grade 2. Through this study, we conclude that FNAC remains the gold standard method despite having different diagnostic modalities accessible for diagnosing thyroid lesions. Grading of FNAC Smears depends on lymphocytic infiltration of the thyroid follicles, along with positivity for antithyroid antibodies (anti-TPO antibody) and TSH. These findings are firmly associated with Chronic Lymphocytic Thyroiditis.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

A study of fine needle aspiration cytology findings with thyroid function test, anti-thyroid antibody, and clinical pathological parameters in cases of chronic lymphocytic thyroiditis

Marachapu

Vij²

2023

IJPO

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“…The euthyroid status in grade I thyroiditis could be due to lesser number of follicular cell destruction and lymphocytic infiltration and the hypothyroid status in grade II thryoiditis is due to progressive loss of follicular cells and their replacement by the lypmhoplasmacytic infiltrate. In grade III thyroiditis(2%) most cases were hypothyroid(2%) which is similar to study done by P. Ashwin et al [13] Higher grades of thyroiditis is associated with abnormal hormonal or biochemical assay. Though our study was significant clinically statistically it was not significant.…”

Section: Discussionsupporting

confidence: 88%

Correlation of Biochemical Parameters with Cytomorphological grading in Hashimoto’s Thyroiditis

Sharma

Alva

2019

APALM

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Background: Hashimoto's thyroiditis (HT) is one of the most common cause of hypothyroidism in iodine sufficient areas. Diagnosis of HT is based on clinical, cytomorphological and biochemical parameters. Fine Needle Aspiration Cytology (FNAC) of thyroid provides a safe and accurate method for diagnosis of HT. Cytological grading of HT helps in assessing the severity of the disease and can predict the thyroid functional status.Methods: Retrospectively, 50 diagnosed cases of HT on FNAC were studied over a period of 6 months in a tertiary care hospital. Clinical, biochemical parameters such as T3, T4 and TSH values were collected. Cytological grading of FNAC smears was done based on Bhatia et al cytological grading system into three grades. These grades were compared with the clinical and biochemical parameters of HT.Result: Of 50 patients, 47 were females. Maximum number of cases were seen between 36 -45 years. Most of the patients presented with goiter. 31 out of 50 (62%) cases were grade II thyroiditis, of them most cases were hypothyroid. 17 out of 50 cases (34%) were grade I thyroiditis, of which most cases were euthyroid biochemically. Conclusion:Higher the grades of HT in cytology the more abnormal are the biochemical parameters. A combined approach of cytological grading along with clinical and biochemical parameters can detect subclinical hypothyroid state which provides a guide to therapy.

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“…1 Fluoride is implicated in thyroid dysfunction that is reflected in changes in certain Chaluvadi JK et al Int J Res Med Sci. 2019 Feb;7 (2): [544][545][546][547][548][549][550] International Journal of Research in Medical Sciences | February 2019 | Vol 7 | Issue 2 Page 545 biochemical parameters in addition to certain cytological changes following under different pathological entities. 2 Thyroid production depends on thyroid status of the individual under physiological conditions.…”

Section: Introductionmentioning

confidence: 99%

“…2019 Feb;7 (2): [544][545][546][547][548][549][550] International Journal of Research in Medical Sciences | February 2019 | Vol 7 | Issue 2 Page 545 biochemical parameters in addition to certain cytological changes following under different pathological entities. 2 Thyroid production depends on thyroid status of the individual under physiological conditions. According to previous studies thyroid gland is found to have higher concentrating ability of these elements than any other tissues in the body.…”

Section: Introductionmentioning

confidence: 99%

Cytomorphological alterations of thyroid gland consequent upon fluorosis

et al. 2019

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Background: Study aimed at assessing the impact of elevated fluoride from drinking water on thyroid gland structure and function in fluorosis prone areas. Iodine is incorporated in the thyroid synthesis by thyroid gland but in the presence of low Iodine levels fluoride is likely to interfere with the concentrating capacity of thyroid of iodine in thyroid production, consequently reflecting changes in thyroid parameters and also cytomorphological features manifesting hypothyroidism in association with different pathological entities.Methods: Prakasam district in Andhra Pradesh is fluorosis prone zone and subjects are picked up from highly vulnerable zone in this district and their specimens are collected to study cytomorphological changes of the thyroid gland and biochemical parameters of blood samples for thyroid function test were considered. Cytological study by way of Fine Needle Aspiration Cytology (FNAC) of thyroid gland, biochemical parameters pertaining to function of thyroid gland namely Free triiodothyronine (FT3), Free Thyroxine (FT4) and Thyroid stimulating hormone (TSH) were assessed in the subjects from fluorosis prone zone.Results: The results were statistically significant with concurrent association of different cytological alterations of thyroid gland in these subjects like Hashimoto’s thyroiditis of hypothyroidism, adenomatous goitre, colloid goitre and few of follicular adenoma/neoplasm. FNAC makes cytological changes evident showing different morphological features that comprise different pathological entities largely with an evidence of hypothyroidism in most of the cases in the given study.Conclusions: The results of the study strongly suggest assessing the magnitude of the problem of fluorosis and also magnitude of its influence on thyroid structure and function that warrants assessment of the thyroid function by biochemical and cytological studies.

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Cytolomorphological, Biochemical & Radiological Correlation in Hashimoto's Thyroiditis

Cited by 3 publications

References 0 publications

A study of fine needle aspiration cytology findings with thyroid function test, anti-thyroid antibody, and clinical pathological parameters in cases of chronic lymphocytic thyroiditis

A study of fine needle aspiration cytology findings with thyroid function test, anti-thyroid antibody, and clinical pathological parameters in cases of chronic lymphocytic thyroiditis

Correlation of Biochemical Parameters with Cytomorphological grading in Hashimoto’s Thyroiditis

Cytomorphological alterations of thyroid gland consequent upon fluorosis

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