Cytoplasmic superoxide dismutase activity is a sensitive indicator of the antioxidant status of the rat liver and brain

Sirota, T. V.; Захарченко, М. В.; Кондрашова, М. Н.

doi:10.1134/s1990750813010101

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…23 SOD, a crucial endogenous antioxidase, plays an important role in protecting cells injury resulted from toxic oxygen-derived free radicals, and the level of SOD is commonly used as a relatively sensitive marker of antioxidant status. 24 We found that rats treated with tirofiban showed a higher activity of SOD and lower level of MDA, indicating that tirofiban exhibited a beneficial effect on SOD activity, resists lipid peroxidation, and blocks ischemiareperfusion injury via increased free radical scavenging.…”

Section: Discussionmentioning

confidence: 75%

Effects of Tirofiban on Random Skin Flap Survival in Rats

Cheng

Chen

et al. 2017

J reconstr Microsurg

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Section: Discussionmentioning

confidence: 75%

Effects of Tirofiban on Random Skin Flap Survival in Rats

Cheng

Chen

et al. 2017

J reconstr Microsurg

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“…Inflammation greatly compromises flap survival [ 31 ]. The level of MDA (a major marker of lipid peroxidation) directly reflects the extent of tissue injury [ 32 ]. SOD, a crucial endogenous anti-oxidase, protects cells from injury caused by toxic oxygen-derived free radicals, and the SOD level is a sensitive indicator of antioxidant status [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Naringin improves random skin flap survival in rats

Cheng

Chen

et al. 2017

Oncotarget

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BackgroundRandom-pattern flap transfer is commonly used to treat soft-tissue defects. However, flap necrosis remains a serious problem. Naringin accelerates angiogenesis by activating the expression of vascular endothelial growth factor (VEGF). In the present study, we investigated whether naringin improves the survival of random skin flaps.ResultsCompared with controls, the naringin-treated groups exhibited significantly larger mean areas of flap survival, significantly increased SOD activity and VEGF expression, and significantly reduced MDA level. Hematoxylin and eosin (HE) staining revealed that naringin promoted angiogenesis and inhibited inflammation.Materials and Methods“McFarlane flap” models were established in 90 male Sprague-Dawley (SD) rats divided into three groups: a 40 mg/kg control group (0.5 % sodium carboxymethylcellulose), a 40 mg/kg naringin-treated group, and an 80 mg/kg naringin-treated group. The extent of necrosis was measured 7 days later, and tissue samples were subjected to histological analysis. Angiogenesis was evaluated via lead oxide–gelatin angiography, immunohistochemistry, and laser Doppler imaging. Inflammation was evaluated by measurement of serum TNF-α (tumor necrosis factor-α) and IL-6 (interleukin-6) levels. Oxidative stress was assessed by measuring superoxide dismutase (SOD) activity and the malondialdehyde (MDA) level.ConclusionNaringin improved random skin flap survival.

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“…SOD, as an important antioxidase, is the predecessor of H 2 O 2 and OH − , protecting tissue from injury caused by toxic oxygen-derived free radicals. It is a sensitive indicator of antioxidant status (35). As a product of lipid peroxidation, MDA indirectly reflects the extent of tissue damage due to ischemia-reperfusion injury (36).…”

Section: Discussionmentioning

confidence: 99%

Effects of diammonium glycyrrhizinate on random skin flap survival in rats: An experimental study

Gao

Lin

et al. 2016

Biomedical Reports

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Abstract. Partial necrosis of skin flaps continues to restrict the survival of local skin flaps following plastic and reconstructive surgeries. The aim of the present study was to investigate the effects of diammonium glycyrrhizinate (DG), a salt of glycyrrhetinic acid that has been widely used in the therapy of chronic hepatitis and human immunodeficiency virus infection, on random skin flap survival in rats. McFarlane flaps were established in 60 male Sprague-Dawley rats randomly divided into three groups. Group I served as the control group and was injected with saline (10 mg/kg) once per day. Group II and group III were the experimental groups, and were injected with 10 mg/kg DG once and twice per day, respectively. On day 7, the survival area of the flap was measured. Tissue samples were stained with hematoxylin and eosin and immunohistochemically evaluated. Tissue edema, neutrophil density, superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels were evaluated. The mean survival areas of the flaps of group II were significantly larger when compared with those of group I (P<0.05), and the rats of group III exhibited significantly higher survival areas than group II (P<0.05). Histologic and immunohistochemical evaluation showed that microvessel development and the expression level of vascular endothelial growth factor were higher in the two experimental groups than in the control group. Furthermore, SOD activity was significantly increased (P<0.05), while the neutrophil density and MDA level were significantly reduced (P<0.05) in group II when compared with group I. Significant differences between group II and group III with regard to SOD activity and MDA level were also observed (P<0.05). Thus, DG may have a dose-dependent effect on promoting the survival of random skin flaps.

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Cytoplasmic superoxide dismutase activity is a sensitive indicator of the antioxidant status of the rat liver and brain

Cited by 8 publications

References 12 publications

Effects of Tirofiban on Random Skin Flap Survival in Rats

Effects of Tirofiban on Random Skin Flap Survival in Rats

Naringin improves random skin flap survival in rats

Effects of diammonium glycyrrhizinate on random skin flap survival in rats: An experimental study

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