Cytosorb treatment in severe COVID-19 cardiac and pulmonary disease

Ciabatti, Michele; Martinese, Lucia; Quacquarelli, Antonio; Pieroni, Maurizio; Feri, Marco; Bolognese, Leonardo

doi:10.1093/ehjcr/ytab123

Cited by 2 publications

(1 citation statement)

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“…reported the use of remdesivir, IL-6 inhibitors and intravenous immunoglobulins in a large cohort of patients with COVID-19 related myocarditis 39 . Anecdotal use of immunoadsorption in severe cardiac and pulmonary COVID-19 infection has been also described 57 .…”

Section: Management and Outcomementioning

confidence: 99%

Myocarditis and COVID-19 related issues

Ciabatti,

Zocchi,

Olivotto

et al. 2023

gcsp

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The recent COVID-19 (Coronavirus Disease 2019) pandemic by SARS-CoV2 infection has caused millions of deaths and hospitalizations across the globe. In the early pandemic phases, the infection had been initially considered a primary pulmonary disease. However, increasing evidence has demonstrated a wide range of possible cardiac involvement. Most of systemic and cardiac damage is likely sustained by a complex interplay between inflammatory, immune-related and thrombotic mechanisms. Biventricular failure and myocardial damage with elevation of cardiac biomarkers have been reported in COVID-19 patients, although histological demonstration of acute myocarditis has been rarely documented. Indeed while cardiac magnetic resonance findings include different patterns of myocardial involvement in terms of late gadolinium enhancement, histological data from necropsy and endomyocardial biopsy showed peculiar inflammatory patterns, mostly composed by macrophages. On the other hand COVID-19 vaccines based on mRN technology have been also associated with increased risk of myocarditis. COVID-19 and mRNA vaccine-related myocarditis present different clinical and imaging presentations and recent data suggest the presence of distinctive immunological mechanisms involved.

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Section: Management and Outcomementioning

confidence: 99%