Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes

Patysheva, Marina; Стахеева, М. Н.; Larionova, Irina; Федоров, А. А.; Kzhyshkowska, Julia; Чердынцева, Н. В.

doi:10.32471/exp-oncology.2312-8852.vol-41-no-3.13597

Cited by 3 publications

(2 citation statements)

References 67 publications

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“…In a recent review, Patysheva et al indicated that the response of monocyte/macrophage cells to treatment by cytostatic agents is probably realized due to a change in the function of these cells. Moreover, the authors suggest that chemotherapeutic treatment might also affect the functional polarization of monocytes and macrophages and modulate their epigenetic profile and activate recruitment from the bone marrow and migration to the tumor site (Patysheva et al 2019). In agreement with other studies, ~ 40% depletion of the ability of monocyte/macrophage cells to proliferate after treatment by 5-FU has been observed (Fig.…”

Section: Biological Studiesmentioning

confidence: 99%

Synergistic effect of folate-conjugated polymers and 5-fluorouracil in the treatment of colon cancer

Siemiaszko

Niemirowicz-Laskowska

Markiewicz

et al. 2021

Cancer Nano

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Background In recent years, targeted drug delivery strategies have received special attention from the scientific world due to advantages such as more effective therapy and reduction of side effects. The principle of operation is delayed excretion from the bloodstream of the drug delivery system compared to the drug itself, as well as facilitated penetration into diseased cells thanks to the use of ligands recognized by appropriate receptors. Particularly interesting drug carriers are amphiphilic copolymers that form nano-sized micelles with a drug, which can release the drug at a specific place in the body under the influence of appropriate stimuli. Results We describe the synthesis of the diblock polymer, poly(2-hydroxyethyl acrylate)-b-poly(N-vinylcaprolactam) using RAFT/MADIX (Reversible Addition-Fragmentation chain Transfer/MAcromolecular Design by Interchange of Xanthate) controlled polymerization affording polymers with good dispersity according to SEC (Size-Exclusion Chromatography). Some post-modifications of the polymer with folic acid were then performed as evidenced by NMR (Nuclear Magnetic Resonance), UV–Vis (UltraViolet–Visible) and FT-IR (Fourier-Transform Infrared) spectroscopy, and TGA (ThermoGravimetric Analysis). The formation of stable micellar systems from polymers with and without the drug, 5-fluorouracil, was confirmed by DLS (Dynamic Light Scattering) and zeta potential measurements, and TEM (Transmission Eelectron Microscopy) imaging. Finally, the cloud point of the polymers was investigated, which turned out to be close to the temperature of the human body. Most importantly, these micellar systems have been explored as a drug delivery system against colon cancer, showing increased cytotoxicity compared to the drug alone. This effect was achieved due to the easier cellular uptake by the interaction of folic acid and its receptors on the surface of cancer cells. Conclusions The presented results constitute a solid foundation for the implementation of a nano-sized drug delivery system containing folic acid for practical use in the treatment of drug-resistant cancer, as well as more effective therapy with fewer side effects. Graphical Abstract

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Section: Biological Studiesmentioning

confidence: 99%

Synergistic effect of folate-conjugated polymers and 5-fluorouracil in the treatment of colon cancer

Siemiaszko

Niemirowicz-Laskowska

Markiewicz

et al. 2021

Cancer Nano

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“…Chemotherapeutic agents can affect monocyte subpopulations in circulation blood ( 160 , 188 , 189 ). In breast cancer cohort, the amount of CD3-CD14+CD16- monocytes was increased during 5 cycles of doxorubicin, dramatically decreased after 5 th cycle, but then has reсovered after following 3 cycles of paclitaxel treatment ( 183 ).…”

Section: Effects Of Treatment On Circulating Monocytesmentioning

confidence: 99%

Monocyte programming by cancer therapy

et al. 2022

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Monocytes in peripheral blood circulation are the precursor of essential cells that control tumor progression, that include tumor-associated macrophages (TAMs), dendritic cells (DCs) and myeloid-derive suppressor cells (MDSC). Monocytes-derived cells orchestrate immune reactions in tumor microenvironment that control disease outcome and efficiency of cancer therapy. Four major types of anti-cancer therapy, surgery, radiotherapy, chemotherapy, and most recent immunotherapy, affect tumor-associated macrophage (TAM) polarization and functions. TAMs can also decrease the efficiency of therapy in a tumor-specific way. Monocytes is a major source of TAMs, and are recruited to tumor mass from the blood circulation. However, the mechanisms of monocyte programming in circulation by different therapeutic onsets are only emerging. In our review, we present the state-of-the art about the effects of anti-cancer therapy on monocyte progenitors and their dedifferentiation, on the content of monocyte subpopulations and their transcriptional programs in the circulation, on their recruitment into tumor mass and their potential to give origin for TAMs in tumor-specific microenvironment. We have also summarized very limited available knowledge about genetics that can affect monocyte interaction with cancer therapy, and highlighted the perspectives for the therapeutic targeting of circulating monocytes in cancer patients. We summarized the knowledge about the mediators that affect monocytes fate in all four types of therapies, and we highlighted the perspectives for targeting monocytes to develop combined and minimally invasive anti-cancer therapeutic approaches.

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Docking and Molecular Dynamics Studies on DNA-Heterocyclic Enediynes Interaction to Identify the Preferred Binding Mode

Gureev,

Danilkina,

Khlebnikov

et al. 2024

Russ J Gen Chem

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Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes

Cited by 3 publications

References 67 publications

Synergistic effect of folate-conjugated polymers and 5-fluorouracil in the treatment of colon cancer

Synergistic effect of folate-conjugated polymers and 5-fluorouracil in the treatment of colon cancer

Monocyte programming by cancer therapy

Docking and Molecular Dynamics Studies on DNA-Heterocyclic Enediynes Interaction to Identify the Preferred Binding Mode

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