Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucoside

Flaxseed lignan secoisolariciresinol diglucoside improves insulin sensitivity through upregulation of GLUT4 expression in diet-induced obese mice

“…Phytoestrogens have gained increasing attention in recent years because of accumulating evidence implying their protective roles against numerous metabolic disorders (Ayella et al, 2010;Bhathena & Velasquez, 2002;Pan et al, 2007;Truan et al, 2012). The health benefits of flaxseed or flaxseed lignans on glucose metabolism are less studied and there is lack of consistency among studies although the benefits have been reported (Adolphe et al, 2010).…”

Antiproliferative activity of yatein isolated fromAustrocedrus chilensisagainst murine myeloma cells: Cytological studies and chemical investigations

“…The most active compounds are phenolic diterpenes and lignans, and among them matairesinol, podophyllotoxin, yatein, ferruginol, and 6,7-dehydroferruginol (Banskota et al, 2003;Donoso et al, 2008, Donoso-Fierro et al, 2009. Lignans represent one of the most important and interesting classes of biologically active compounds, because lignan molecules can induce cancer cell apoptosis (Ayella et al, 2010;Chavez et al, 2011;Huong et al, 2011;Singh et al, 2007;Xu et al, 2006Xu et al, , 2011. Podophyllotoxin inhibits microtubule assembly of the mitotic apparatus, acting as a competitive inhibitor of the binding site for colchicine to tubulin (Loike et al, 1978); this process occurs during mitosis, where the microtubules are rearranged to form the mitotic spindle, which is essential for cell division (Ayres & Loik, 1990;Islam & Iskander, 2004;Schmidt & Bastians, 2007).…”

Plant and mammalian lignans: A review of source, intake, metabolism, intestinal bacteria and health

“…Cell growth inhibition by lignan metabolites seems to be mediated by cytostatic and apoptotic mechanisms (Ayella et al, 2010, Qu et al, 2005.…”

“…Epidemiological and pharmacological studies reveal that END and its oxidation product ENL, in particular, afford protection against osteoporosis, cardiovascular diseases, hyperlipidemia, breast cancer, colon cancer, prostate cancer and menopausal syndrome (Adlercreutz, 2007;Feng, Shi, & Ye, 2008;Adolphe, Whiting, Juurlink, Thorpe & Alcom, 2010;Ayella et al, 2010;Zaineddin et al (2011).…”