Cytotoxic Activity and Apoptosis Induction of Hypericum scabrum L.

Hamzeloo-Moghadam, Maryam; Khalaj, Amir; Malekmohammadi, Maryam

doi:10.5812/ircmj.19453

Cited by 15 publications

(12 citation statements)

References 36 publications

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“…The cytotoxic activity of F. assa-foetida was attributed to its main coumarin component, umbelliprenin, which induced apoptosis in chronic lymphocytic leukemia cell lines in a dose- and time-dependent manner, where interleukin-4 had no effect on apoptosis induction ( Ziai et al, 2012 ). The caspase-3 and annexin-V/propidium iodide assays confirmed that the methanol extract of Hypericum scabrum originated from Iran induced apoptosis in MCF7 cells ( Hamzeloo-Moghadam et al, 2015 ).…”

Section: Mechanisms Of Actions Of Medicinal Plants From Near East Towmentioning

confidence: 77%

Medicinal Plants from Near East for Cancer Therapy

Abu-Darwish

Efferth

2018

Front. Pharmacol.

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Background: Cancer is one of the major problems affecting public health worldwide. As other cultures, the populations of the Near East rely on medicinal herbs and their preparations to fight cancer.Methods: We compiled data derived from historical ethnopharmacological information as well as in vitro and in vivo results and clinical findings extracted from different literature databases including (PubMed, Scopus, Web of Science, and Google Scholar) during the past two decades.Results: In this survey, we analyzed the huge amount of data available on anticancer ethnopharmacological sources used in the Near East. Medicinal herbs are the most dominant ethnopharmacological formula used among cancer’s patients in the Near East. The data obtained highlight for the first time the most commonly used medicinal plants in the Near East area for cancer treatment illustrating their importance as natural anticancer agents. The literature survey reveals that various Arum species, various Artemisia species, Calotropis procera, Citrullus colocynthis, Nigella sativa, Pulicaria crispa, various Urtica species, Withania somnifera, and others belong to the most frequently used plants among cancer patients in the Near East countries. Molecular modes of action that have been investigated for plant extracts and isolated compounds from Near East include cell cycle arrest and apoptosis induction with participation of major player in these processes such as p53 and p21, Bcl-2, Bax, cytochrome c release, poly (ADP-ribose) polymerase cleavage, activation of caspases, etc.Conclusion: The ethnopharmacology of the Near East was influenced by Arabic and Islamic medicine and might be promising for developing new natural and safe anticancer agents. Further research is required to elucidate their cellular and molecular mechanisms and to estimate their clinical activity.

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Section: Mechanisms Of Actions Of Medicinal Plants From Near East Towmentioning

confidence: 77%

Medicinal Plants from Near East for Cancer Therapy

Abu-Darwish

Efferth

2018

Front. Pharmacol.

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“…Four compounds were isolated from the dichloromethane extract: taraxasterol, pseudotaraxasterol, β-sitosterol, and 7-methoxycoumarin. Taraxasterol and 7-methoxycoumarin are known in scientific literature to present anticancer properties; this fact, along with the encouraging results of the study, makes Anthemis mirheydari a new potential anticancer medicinal plant that certainly deserves further investigations [32].…”

Section: Antioxidant Activitymentioning

confidence: 88%

“…The results evidenced strong cytotoxicity against HT-29 and HepG-2 cell lines and interesting apoptosis induction ability; the authors suggested further studies in this field [35]. Jassbi et al (2016) [32] tested the cytotoxic activity, against three human cancer cell lines (LS180, MCF-7, and MOLT-4), of dichloromethane and methanol extracts of Anthemis mirheydari, an endemic plant from Iran. The plant samples were collected in Jahrom in Fars province, Iran, and the whole plant was used for the extraction.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Iranian Medicinal Plants: From Ethnomedicine to Actual Studies

et al. 2020

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Iran has a rich and diverse cultural heritage, consisting of a complex traditional medicine deeply rooted in the history of the territory that goes back to the Assyrian and Babylonian civilizations. The ethnomedical practices that can be identifiable nowadays derive from the experience of local people who have developed remedies against a wide range of diseases handing down the knowledge from generation to generation over the millennia. Traditional medicine practices represent an important source of inspiration in the process of the development of new drugs and therapeutic strategies. In this context, it is useful to determine the state of the art of ethnomedical studies, concerning the Iranian territory, and of scientific studies on plants used in traditional Iranian medicine. Data regarding 245 plants used in Iranian ethnomedical practices and scientific studies conducted on 89 plants collected in the Iranian territory have been reported. All of the scientific studies here reported draw inspiration from traditional medicine. The World Health Organization (WHO) has repeatedly called for an intensification of the scientific validation processes of traditional medicines intended as an important contribution to public health in various parts of the world. The process of study and validation of Iranian ethnomedical practices appears to be at an early stage.

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“…In contrast, H. scabrum extracts have been reported to inhibit both lipoxygenase and cyclooxygenase pathways, which then reduces inflammatory factors [76,77]. Additionally, it has been reported that, the H. scabrum extract has anti-inflammatory properties [78] that probably result from the flavonoids in the extract [79].…”

Section: Discussionmentioning

confidence: 99%

Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats

et al. 2020

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High-fat diet (HFD) can induce deficits in neural function, oxidative stress, and decrease hippocampal neurogenesis. Hypericum (H.) scabrum extract (Ext) contains compounds that could treat neurological disorders. This study aimed to examine the neuroprotective impacts of the H. scabrum Ext on hippocampal synaptic plasticity in rats that were fed HFD. Fifty-four male Wistar rats (220 ± 10 g) were randomly arranged in six groups: (1) HFD group; (2) HFD + Ext300 group; (3) HFD + Ext100 group; (4) Control group; (5) Ext 300 mg/kg group; (6) Ext 100 mg/kg group. These protocols were administrated for 3 months. After this stage, a stimulating electrode was implanted in the perforant pathway (PP), and a bipolar recording electrode was embedded into the dentate gyrus (DG). Long-term potentiation (LTP) was provoked by high-frequency stimulation (HFS) of the PP. Field excitatory postsynaptic potentials (EPSP) and population spikes (PS) were recorded at 5, 30, and 60 min after HFS. The HFD group exhibited a large and significant decrease in their PS amplitude and EPSP slope as compared to the control and extract groups. In reverse, H. scabrum administration in the HFD + Ext rats reversed the effect of HFD on the PS amplitude and EPSP slope. The results of the study support that H. scabrum Ext can inhibit diminished synaptic plasticity caused by the HFD. These effects are probably due to the extreme antioxidant impacts of the Ext and its capability to scavenge free radicals.

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Cytotoxic Activity and Apoptosis Induction of Hypericum scabrum L.

Cited by 15 publications

References 36 publications

Medicinal Plants from Near East for Cancer Therapy

Medicinal Plants from Near East for Cancer Therapy

Iranian Medicinal Plants: From Ethnomedicine to Actual Studies

Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats

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