Cytotoxic acyl amides from the soil fungus Gymnascella dankaliensis

Hammerschmidt, Lena; Aly, Amal H.; Abdel‐Aziz, Mohamed S.; Müller, Wernér E.G.; Lin, Wenhan; Proksch, Peter

doi:10.1016/j.bmc.2014.12.068

Cited by 23 publications

(24 citation statements)

References 41 publications

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“…Two flasks were used for each experiment and each flask contained 100 g rice, 110 mL demineralized water and 3.5 g salts. The usefulness of 3.5% salts in the OSMAC approach has been proved by previous experiments with other fungi ( Hammerschmidt et al, 2015 ; Wang et al, 2016 , 2018 ). Based on the chromatographic profiles obtained from the extractions of these fermentations, fungal cultivations with striking changes of metabolite patterns were selected for further investigation.…”

Section: Methodsmentioning

confidence: 93%

“…Due to the pronounced chemical diversity of natural products obtained from this fungus, we have now conducted an OSMAC study which involved the addition of different salts including 3.5% NaBr, 3.5% NaCl, 3.5% NaF, 3.5% KCl, 3.5% NH 4 Cl, 3.5% (NH 4 ) 2 SO 4 , 3.5% C 5 H 8 NNaO 4 ⋅H 2 O (monosodium glutamate), 3.5% NaNO 3 , 3.5% Na 2 HPO 4 , 3.5% K 2 HPO 4 ⋅3H 2 O, 3.5% KH 2 PO 4 , 3.5% FeSO 4 , 3.5% ZnSO 4 , or 3.5% MgSO 4 to solid rice medium. The selection of most of these salts was based on previous studies which indicated their usefulness for activation of non-transcribed biosynthetic gene clusters ( Hammerschmidt et al, 2015 ; Wang et al, 2016 , 2018 ; Ariantari et al, 2019 ). The most striking effects with regard to an alteration of the fungal metabolite pattern, however, were detected following addition of either 3.5% NaNO 3 or of 3.5% monosodium glutamate to solid rice medium compared to fungal control cultures lacking either of these activators ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach

et al. 2020

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Fermentation of the endophytic fungus Aplosporella javeedii on solid rice medium in presence of either 3.5% NaNO 3 or 3.5% monosodium glutamate caused a significant change of the fungal metabolite pattern compared to fungal controls grown only on rice. Chemical investigation of the former fungal extracts yielded 11 new lactam derivatives, aplosporellins A–K ( 2 – 12 ), in addition to the known compound, pramanicin A ( 1 ). All of these compounds were not detected when the fungus was grown on rice medium without these activators thereby indicating the power of this OSMAC approach. The structures of the new compounds were elucidated by one- and two- dimensional NMR spectroscopy, DFT-NMR calculations and by mass spectrometry as well as by comparison with the literature whereas the absolute configuration of the lactam core was determined by TDDFT-ECD and OR calculations. Pramanicin A ( 1 ) showed strong cytotoxicity against human lymphoma (Ramos) and leukemia (Jurkat J16) cells with IC 50 values of 4.7 and 4.4 μM, respectively. Mechanistic studies indicated that 1 activates caspase-3 and induces apoptotic cell death.

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Section: Methodsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach

et al. 2020

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“…Among the compounds, aluminiumneohydroxyaspergillin exhibited cytotoxicity against the U937 cell line (IC50 = 4.2 µM). L. Hammerschmidt et al isolated twelve compounds from Gymnascella dankaliensis ethyl acetate extract and measured their cytotoxicity against the L5178Y cell line [22]. Four compounds were found to have cytotoxicity.…”

Section: Microorganism-derived Compounds and Lymphomamentioning

confidence: 99%

Review of Natural Compounds for the Management and Prevention of Lymphoma

et al. 2020

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Lymphoma is a type of blood cancer that can be categorized into two types-Hodgkin lymphoma (HL) and Non-Hodgkin lymphoma (NHL). A total of 509,590 and 79,990 cases of NHL and HL were newly diagnosed in 2018, respectively. Although conventional therapy has stridden forward over recent decades, its adverse effects are still a hurdle to be solved. Thus, to help researchers develop better lymphoma treatment, this study aims to review the systematic anticancer data for natural products and their compounds. A variety of natural products showed anticancerous effects on lymphoma by regulation of intracellular mechanisms including apoptosis as well as cell cycle arrest. As these results shed light on the potential to substitute conventional therapy with natural products, it may become a promising strategy for lymphoma treatment in the near future.

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“…21,22 Interestingly, a series of studies have reported the isolation of halogenated natural products from fungal cultures grown on media to which different halide salts had been added, thus highlighting the fungal capability to utilize different halogen sources when present in the media. [23][24][25][26] In addition, supplementing media with trace elements, e.g. the addition of CuCl 2 to cultures of Pestalotiopsis sp.…”

Section: Introductionmentioning

confidence: 99%