Cytotoxic and genotoxic effects induced by associated commercial glyphosate and 2,4-D formulations using the<i>Allium cepa</i>bioassay

Finkler, Mariana; Rodrigues, Gabriela Zimmermann Prado; Kayser, Juliana Machado; Ziulkoski, Ana Luíza; Gehlen, Günther

doi:10.1080/03601234.2022.2034432

Cited by 7 publications

(2 citation statements)

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“…Clastogenic agents can cause or encourage disruption and breakage of chromosomes, and can cause deletions, duplications and translocations of chromosomes. The activity of this clastogenic agent can be carcinogenic, leading to the formation of cancer cells [25].…”

Section: Genotoxicity Assessmentmentioning

confidence: 99%

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Evaluation of cytotoxicity and genotoxicity of the upstream Citarum River using Allium cepa assay

Annisa,

Mulyawan,

Sunardi

2024

E3S Web Conf.

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Citarum River is the longest and largest river in West Java, and its existence greatly influences the lives of surrounding communities. Many industries are built around the area. It is important to assess the quality of the water, because certain heavy metal might leak to the body of water. This research aimed to investigate the mitotic index (MI), root length, frequency and types of chromosomal aberration which determined the cytotoxicity and genotoxicity by using Allium cepa L. as biomarker. The Completely randomized design with seven treatments and four replications were used. Observation was done 96 hours after onion bulb soaked in water. Data was analysed using Analysis of Variance and continued with Duncan post-hoc. Results showed that root length was not affected. Water samples were affecting the MI, frequency, and types of chromosomal aberration. The highest number of chromosome aberrations was recorded on Dayeuh Kolot stations and the most common type of aberration was stickiness. The chromosome aberrations observed were; stickiness, chromosome loss, chromosome bridge, chromosome break, binucleated cells, multipolar, micronuclei, and c-mitosis. Based on the results, Allium assay is beneficial to evaluate the level of cytotoxicity and genotoxicity in the upstream Citarum River.

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Section: Genotoxicity Assessmentmentioning

confidence: 99%

“…Herbicide might be a source of aneugenic. Research by [25], regarding the genotoxic effects of the herbicides glyphosate and 2,4dichlorophenoxyacetic acid was done using the Allium assay method. The results of this study showes that all the compounds tested were able to induce chromosomal aberrations in A. cepa onion root cells.…”

Section: Genotoxicity Assessmentmentioning

confidence: 99%