Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma

Ayyad, Seif‐Eldin N.; Makki, Mohamed S. T.; Alkayal, Nazeeha S.; Basaif, Salem A.; El‐Foty, Kalid O.; Asiri, Abdullah M.; Alarif, Walied M.; Badria, Farid A.

doi:10.1016/j.ejmech.2010.10.033

Cited by 46 publications

(44 citation statements)

References 20 publications

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“…Error bars represent standard deviation cilliolata, was also tested for its anticancer potential in different cell lines including MCF-7 (Caamal-Fuentes et al 2014) and in this study, the extract was effective only at microgram per mL concentrations. Furthermore in several studies focusing on the anti-cancer potential of pure compounds isolated from Dictyota species in different cell lines including MCF-7, IC 50 values calculated for all of the compounds were at microgram per mL scale (Jongaramruong and Kongkam 2007;Ayyad et al 2011;Abou-El-Wafa et al 2013;Pardo-Vargas et al 2014). Since our extract was much more effective compared to all counterparts and to all pure compounds mentioned, we believe either the extract itself or the active compounds of the extract have a strong potential to be used as anti-cancer agent.…”

Section: Discussionmentioning

confidence: 99%

Macroalgae of Izmir Gulf: Dictyotaceae exhibit high in vitro anti-cancer activity independent from their antioxidant capabilities

2016

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In this study, 24 marine macroalgae collected from the coastline of Izmir Gulf were examined for their antioxidant activities and their effects on cell proliferation. Crude extracts were obtained from samples with cold methanol extraction. Antioxidant activity was evaluated as 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity and total phenolic content (TPC); growth inhibitory effects of the extracts were determined by using WST-8. Amongst the species, Polysiphonia denuata (Rhodophyta) and Cystoseira species (Phaeophyceae) have been noticed by their high DPPH radical scavenging activities and TPCs. As expected, there was a strong correlation between these tests. Dictyota dichotoma (Phaeophyceae) showed the highest anti-cancer activity on MCF-7 cells with an IC 50 of 17.2 ng mL -1 . Flow cytometry analyses demonstrated that D. dichotoma methanolic extract strongly induced apoptosis.This extract exhibited moderate viability inhibition on MCF10A cells (IC 50 : 49.3 ng mL -1 ), suggesting a potential use of the extracts or its compounds for cancer therapy. There was no correlation between anticancer potential and antioxidant content of the extracts.

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Section: Discussionmentioning

confidence: 99%

Macroalgae of Izmir Gulf: Dictyotaceae exhibit high in vitro anti-cancer activity independent from their antioxidant capabilities

2016

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“…In continuation of our search program, which interested in the isolation of secondary metabolites from marine sources, especially macroalgae collected from Red Sea,[15–17] a marine macroalgae, identified as Sargassum sp., collected from El- Shuaiba lagoon 80 km south of Jeddah, was investigated. The total extract (Pet.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp

Ayyad¹,

Ezmirly²,

Basaif³

et al. 2011

Phcog Res

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Background:Macroalgae can be viewed as a potential antioxidant and anti-inflammatory sources owing to their capability of producing compounds for its protection from environmental factors such as heat, pollution, stress, oxygen concentration, and UV radiations.Objective:To isolate major compounds which are mainly responsible for the pharmacological activity of brown alga under investigation, Sargassum sp.Materials and Methods:Algal material was air dried, extracted with a mixture of organic solvents, and fractionated with different adsorbents. The structures of obtained pure compounds were elucidated with different spectroscopic techniques, and two pure materials were tested for protection of DNA from damage, antioxidant, antitumor, and cytotoxicity.Results:Four pure compounds were obtained, of which fucosterol (1) and fucoxanthin (4) were tested; it was found that fucoxanthin has strong antioxidant and cytotoxicity against breast cancer (MCF-7) with IC50 = 11.5 μg/ml.Conclusion:The naturally highly conjugated safe compound fucoxanthin could be used as antioxidant and as an antitumor compound.

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“…Recently, the isolation of a new asymmetric bis-diterpene dictyotadimer A (28) from the genus Dictyota Lamouroux was reported (Viano et al, 2011), while at the same time antiviral diterpenes (29) were found in Dictyota menstrualis (Hoyt) Schetter, Höming & Weber-Peukert (Cavalcanti et al, 2011). Ayyad et al (2011) described the new diterpene amijiol acetate (30) from Dictyota dichotoma (Hudson) J. V.…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products: chemical and biological potential of seaweeds and their endophytic fungi

Oliveira¹,

Felício²,

Debonsi³

2012

Rev. bras. farmacogn.

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Marine natural products have currently been recognized as the most promising source of bioactive substances for drug discovery research. In this review, extraordinary metabolites from marine algae species are illustrated, as well as approaches for their isolation and determination of their biological properties and pharmaceutical potential. Furthermore, marine endophytic microorganisms (from marine algae) are presented as a new subject for extensive investigation to find novel natural products, which make them a potentially rich and innovative source for new drug candidates.

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Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma

Cited by 46 publications

References 20 publications

Macroalgae of Izmir Gulf: Dictyotaceae exhibit high in vitro anti-cancer activity independent from their antioxidant capabilities

Macroalgae of Izmir Gulf: Dictyotaceae exhibit high in vitro anti-cancer activity independent from their antioxidant capabilities

Antioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp

Marine natural products: chemical and biological potential of seaweeds and their endophytic fungi

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