Cytotoxic cassaine diterpenoid–diterpenoid amide dimers and diterpenoid amides from the leaves of Erythrophleum fordii

Du, Dan; Qu, Jing; Wang, Jiaming; Yu, Shi‐Shan; Chen, Xiaoguang; Xu, Song; Ma, Shuang‐Gang; Li, Yong; Ding, Guofang; Fang, Liwei

doi:10.1016/j.phytochem.2010.07.004

Cited by 31 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Erythrophleum fordii belongs to the Fabaceae family and is an excellent hardwood tree species for furniture, bridges, and shipbuilding (Huang et al, ) and a medicinal tree species for promoting blood circulation (Du et al, ). The tree can reportedly live for 1000 years and its height can reach up to 30 m (Chen et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…Erythrophleum fordii Oliver, popularly called “iron wood,” is a famous, excellent hardwood tree species native to China and Vietnam. Due to its superior wood and medicinal uses, its natural populations have suffered serious exploitation (Huang et al, ; Du et al, ). Currently, E. fordii has been listed in the China/Vietnam plant red data book (Fu & Jin, ; Anon, ) and has also been placed in the “endangered” category by the International Union for Conservation of Nature (Nghia, ), suggesting the need for its urgent conservation.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Maintenance of genetic diversity in a small, isolated population of ancient tree Erythrophleum fordii

Zhu

Wang

et al. 2013

J of Sytematics Evolution

View full text Add to dashboard Cite

Ancient trees remaining in natural areas from once widespread forest due to overexploitation and habitat modification would naturally regenerate to form small isolated populations after the halting of disturbance. The genetic processes and consequence of this regeneration are generally unknown, which prevents the effective conservation and management of these populations. One such population, an Erythrophleum fordii population, is located in Dinghushan National Nature Reserve (China). Owing to the remarkably huge trunk of the sole ancient tree (KG) relative to the other individuals in the population, the local people and local tourism administration presume that this population has developed solely from KG. We found, using genetic diversity analyses, that contrary to this presumption, the population might have regenerated from several founders with diverse genetic backgrounds. Severe degradation of genetic diversity within the population did not take place, rather, it possessed the potential ability to maintain and recover gradually with population development. According to the results of simulations, we found that the longevity of tree species with iteroparity offers the potential to maintain genetic diversity in small isolated populations. The results from this study will benefit the restoration and conservation of the endangered species E. fordii, and of other congener species and tree species with similar life history traits.

show abstract

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Maintenance of genetic diversity in a small, isolated population of ancient tree Erythrophleum fordii

Zhu

Wang

et al. 2013

J of Sytematics Evolution

View full text Add to dashboard Cite

show abstract

“…Nine diterpenoid dimers were isolated from plants of the genus Erythrophleum. They possess an unsymmetrical dimeric structure with two cassanoid units linked through an ester bond at C-16 and C-3′ [56][57][58]. These compounds could be considered as taxonomic markers of this genus.…”

Section: Family Fabaceaementioning

confidence: 99%

“…Erythrophlesins A-C exhibited significant TRAIL resistance-overcoming activity in human gastric adenocarcinoma cells. A detailed phytochemical investigation of the leaves of E. fordii resulted in the isolation of three cassanoid dimers, namely erythrophlesins E-G (64-66), all of which were found to contain an amide group [57]. Their structures were determined by extensive 1D and 2D NMR analyses and ESIMS.…”

Section: Family Fabaceaementioning

confidence: 99%

Untitled

2016

Planta Med

View full text Add to dashboard Cite

“…E. fordii contains cassaine diterpenoid amide alkaloids, triterpenoids and steroids. Many of them show pharmaceutical and biological activity as anticancer, antioxidant, and anti-inflammatory agents [ 2 , 3 , 4 , 5 , 6 ]. Previously, we had isolated many mono- and dimeric cassaine diterpenoid amides from the stem bark of Vietnamese E. fordii .…”

Section: Introductionmentioning

confidence: 99%

Cassaine Diterpenoid Amide from Stem Bark of Erythrophleum fordii Suppresses Cytotoxic and Induces Apoptosis of Human Leukemia Cells

Nguyen

Cuong

et al. 2020

Molecules

View full text Add to dashboard Cite

Cassaine diterpenoids amides from the stem bark of Vietnamese Erythrophleum fordii Oliver were screened for their cytotoxic activity against human cancer cells. The cell proliferation assay results showed that, among the active compounds, 3β-acetyl-nor-erythrophlamide (3AEP) exhibited the most potential cytotoxicity against human leukemia HL-60 and KG cells with IC50 values of 12.0 ± 1.2 and 18.1 ± 2.7 µM, respectively. Treatment of 3AEP resulted in the apoptosis of HL-60 cells via the activation of caspase 3, and poly (ADP-ribose) polymerase (PARP). Molecular docking in silico results showed that the 3AEP can bind to both the procaspase-3 allosteric site and the PARP-1 active site, with binding energies of −7.51 and −9.63 kcal/mol respectively. These results indicated that the stem bark of Vietnamese E. fordii and its cassaine diterpenoid amides may be useful in the apoptosis induction of human leukemia cancer cells.

show abstract

Cytotoxic cassaine diterpenoid–diterpenoid amide dimers and diterpenoid amides from the leaves of Erythrophleum fordii

Cited by 31 publications

References 14 publications

Maintenance of genetic diversity in a small, isolated population of ancient tree Erythrophleum fordii

Maintenance of genetic diversity in a small, isolated population of ancient tree Erythrophleum fordii

Untitled

Cassaine Diterpenoid Amide from Stem Bark of Erythrophleum fordii Suppresses Cytotoxic and Induces Apoptosis of Human Leukemia Cells

Contact Info

Product

Resources

About